19 Result(s)
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Matthew A. Howard III
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Article
Open AccessEpigenetic signals associated with delirium replicated across four independent cohorts
Delirium is risky and indicates poor outcomes for patients. Therefore, it is crucial to create an effective delirium detection method. However, the epigenetic pathophysiology of delirium remains largely unknow...
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Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography
Transcranial magnetic stimulation (TMS) is increasingly used as a noninvasive technique for neuromodulation in research and clinical applications, yet its mechanisms are not well understood. Here, we present t...
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Open AccessTemporally organized representations of reward and risk in the human brain
The value and uncertainty associated with choice alternatives constitute critical features relevant for decisions. However, the manner in which reward and risk representations are temporally organized in the b...
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Open AccessAuthor Correction: Immediate neural impact and incomplete compensation after semantic hub disconnection
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Open AccessImmediate neural impact and incomplete compensation after semantic hub disconnection
The human brain extracts meaning using an extensive neural system for semantic knowledge. Whether broadly distributed systems depend on or can compensate after losing a highly interconnected hub is controversi...
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Amygdala lesions are associated with improved mood after epilepsy surgery
Neuroimaging studies in healthy and clinical populations strongly associate the amygdala with emotion, especially negative emotions. The consequences of surgical resection of the amygdala on mood are not well ...
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Open AccessAuthor Correction: Map** effective connectivity of human amygdala subdivisions with intracranial stimulation
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Open AccessMap** effective connectivity of human amygdala subdivisions with intracranial stimulation
The primate amygdala is a complex consisting of over a dozen nuclei that have been implicated in a host of cognitive functions, individual differences, and psychiatric illnesses. These functions are implemente...
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A speech planning network for interactive language use
During conversation, people take turns speaking by rapidly responding to their partners while simultaneously avoiding interruption1,2. Such interactions display a remarkable degree of coordination, as gaps betwee...
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Open AccessDNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium
The pathophysiological mechanisms of postoperative delirium (POD) are still not clear, and no reliable biomarker is available to differentiate those with and without POD. Pre- and post-surgery blood from epile...
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Open AccessGenome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals
Differential DNA methylation in the brain is associated with many psychiatric diseases, but access to brain tissues is essentially limited to postmortem samples. The use of surrogate tissues has become common ...
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Comparison of spinal cord stimulation profiles from intra- and extradural electrode arrangements by finite element modelling
Spinal cord stimulation currently relies on extradural electrode arrays that are separated from the spinal cord surface by a highly conducting layer of cerebrospinal fluid. It has recently been suggested that ...
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Open AccessNon-linear dependency between spiking response and gamma-band power of local field potentials in the human auditory cortex
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Direct Recordings from the Auditory Cortex in a Cochlear Implant User
Electrical stimulation of the auditory nerve with a cochlear implant (CI) is the method of choice for treatment of severe-to-profound hearing loss. Understanding how the human auditory cortex responds to CI st...
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Power and signal transmission protocol for a contactless subdural spinal cord stimulation device
Wireless signal transmission will play a critical role in develo** reliable subdural spinal cord stimulation systems. We have developed an approach to inductively coupling signals across the epidural spacing...
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Chapter
Invasive Research Methods
Auditory cortex, in the classic sense of the term, is taken to be the cluster of anatomically and physiologically distinct areas of temporal neocortex that are uniquely and reciprocally connected with one anot...
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Seizure termination by acidosis depends on ASIC1a
Acidosis can stop seizures, but it is unclear how it does this. This study demonstrates that the acid-sensing channel ASIC1a is required for either spontaneous or CO2-induced termination of convulsant-induced sei...
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Article
Single-neuron responses to emotional visual stimuli recorded in human ventral prefrontal cortex
Both lesion and functional imaging studies in humans1,2, as well as neurophysiological studies in nonhuman primates3, demonstrate the importance of the prefrontal cortex in representing the emotional value of sen...
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Physiologic effects of nucleus basalis magnocellularis stimulation on rat barrel cortex neurons
Cholinergic neurons in the nucleus basalis magnocellularis (NBM) project to the cerebral cortex and are thought to play an important role in learning and memory, and other cognitive functions. In the present s...
