25 Result(s)

Article

Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci

Smoking is a leading cause of preventable morbidity and mortality. Smoking is heritable, and genome-wide association studies (GWASs) of smoking behaviors have identified hundreds of significant loci. Most GWAS...

Megan Ulmer Carnes, Bryan C. Quach, Linran Zhou, Shizhong Han… in Neuropsychopharmacology (2024)

Article

Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry

Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been limited to European ancestry samples or adjusted to identify ancestry-indepe...

Kynon J. M. Benjamin, Qiang Chen, Nicholas J. Eagles… in Nature Neuroscience (2024)

Article

Prioritization of potential causative genes for schizophrenia in placenta

Our earlier work has shown that genomic risk for schizophrenia converges with early life complications in affecting risk for the disorder and sex-biased neurodevelopmental trajectories. Here, we identify speci...

Gianluca Ursini, Pasquale Di Carlo, Sreya Mukherjee, Qiang Chen… in Nature Communications (2023)

Article

A self-inspected adaptive SMOTE algorithm (SASMOTE) for highly imbalanced data classification in healthcare

In many healthcare applications, datasets for classification may be highly imbalanced due to the rare occurrence of target events such as disease onset. The SMOTE (Synthetic Minority Over-sampling Technique) a...

Tanapol Kosolwattana, Chenang Liu, Renjie Hu, Shizhong Han, Hua Chen… in BioData Mining (2023)

Article

A multimodal deep learning model to infer cell-type-specific functional gene networks

Functional gene networks (FGNs) capture functional relationships among genes that vary across tissues and cell types. Construction of cell-type-specific FGNs enables the understanding of cell-type-specific fun...

Shiva Afshar, Patricia R. Braun, Shizhong Han, Ying Lin in BMC Bioinformatics (2023)

Article

Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed DNAm in 344 samples of human postm...

Kira A. Perzel Mandell, Nicholas J. Eagles, Richard Wilton… in Nature Communications (2021)

Article

Effect of selection bias on two sample summary data based Mendelian randomization

Mendelian randomization (MR) is becoming more and more popular for inferring causal relationship between an exposure and a trait. Typically, instrument SNPs are selected from an exposure GWAS based on their su...

Kai Wang, Shizhong Han in Scientific Reports (2021)

Article

Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals

Differential DNA methylation in the brain is associated with many psychiatric diseases, but access to brain tissues is essentially limited to postmortem samples. The use of surrogate tissues has become common ...

Patricia R. Braun, Shizhong Han, Benjamin Hing… in Translational Psychiatry (2019)

Article

Genome-wide association study of seasonal affective disorder

Family and twin studies have shown a genetic component to seasonal affective disorder (SAD). A number of candidate gene studies have examined the role of variations within biologically relevant genes in SAD su...

Kwo Wei David Ho, Shizhong Han, Jakob V. Nielsen… in Translational Psychiatry (2018)

Article

Identifying noncoding risk variants using disease-relevant gene regulatory networks

Identifying noncoding risk variants remains a challenging task. Because noncoding variants exert their effects in the context of a gene regulatory network (GRN), we hypothesize that explicit use of disease-rel...

Long Gao, Yasin Uzun, Peng Gao, Bing He, **aoke Ma, Jiahui Wang… in Nature Communications (2018)

Article

GLITTER: a web-based application for gene link inspection through tissue-specific coexpression

Accumulating evidence supports the polygenic nature of most complex diseases, suggesting the involvement of many susceptibility genes with small effect sizes. Although hundreds of genes may underlie the geneti...

**angtao Liu, Pengfei Yu, Chao Cheng, James B. Potash, Shizhong Han in Scientific Reports (2016)

Chapter and Conference Paper

Feature Disentangling Machine - A Novel Approach of Feature Selection and Disentangling in Facial Expression Analysis

Studies in psychology show that not all facial regions are of importance in recognizing facial expressions and different facial regions make different contributions in various facial expressions. Motivated by ...

** Liu, Joey Tianyi Zhou, Ivor Wai-Hung Tsang, Zibo Meng… in Computer Vision – ECCV 2014 (2014)

Article

A Genomewide Linkage Scan of Cocaine Dependence and Major Depressive Episode in Two Populations

Cocaine dependence (CD) and major depressive episode (MDE) frequently co-occur with poorer treatment outcome and higher relapse risk. Shared genetic risk was affirmed; to date, there have been no reports of ge...

Bao-Zhu Yang, Shizhong Han, Henry R Kranzler, Lindsay A Farrer… in Neuropsychopharmacology (2011)

Article

A genomewide ordered-subset linkage analysis for alcohol dependence in African-Americans

Shizhong Han, Bao-Zhu Yang, Henry R Kranzler, Joel Gelernter in Genome Biology (2010)