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Article
FGF14 GAA repeat expansion and ZFHX3 GGC repeat expansion in clinically diagnosed multiple system atrophy patients
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Article
Open AccessGait video-based prediction of unified Parkinson’s disease rating scale score: a retrospective study
The diagnosis of Parkinson’s disease (PD) and evaluation of its symptoms require in-person clinical examination. Remote evaluation of PD symptoms is desirable, especially during a pandemic such as the coronavi...
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Article
A diagnostic index based on quantitative susceptibility map** and voxel-based morphometry may improve early diagnosis of Alzheimer’s disease
Voxel-based morphometry (VBM) is widely used to quantify the progression of Alzheimer’s disease (AD), but improvement is still needed for accurate early diagnosis. We evaluated the feasibility of a novel diagn...
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Article
Progressive multifocal leukoencephalopathy with mild clinical conditions and detection of archetype-like JC virus in cerebrospinal fluid
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system with a poor prognosis and is primarily caused by JC virus (JCV) with a mutation called prototype. We en...
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Article
Open AccessCorrelation of active contact location with weight gain after subthalamic nucleus deep brain stimulation: a case series
Weight gain (WG) is a frequently reported side effect of subthalamic deep brain stimulation; however, the underlying mechanisms remain unclear. The active contact locations influence the clinical outcomes of s...
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Article
Composition Dependence of Crystal Structures and Electrical Properties of Ca-Mg-Si Films Prepared by Sputtering
Ca-Mg-Si ternary films were deposited at 300–335°C on (001)Al2O3 substrates by a radio-frequency magnetron sputtering. Amorphous films were obtained for a wide range of compositions but not for single-phase CaMgS...
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Article
The Responsiveness of Triaxial Accelerometer Measurement of Gait Ataxia Is Higher than That of the Scale for the Assessment and Rating of Ataxia in the Early Stages of Spinocerebellar Degeneration
We reported previously that the average medial–lateral gait amplitude while walking on a straight path determined using triaxial accelerometers fixed on the middle of the upper back may be a quantitative and c...
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Article
Open AccessIdentification of plasma microRNA expression changes in multiple system atrophy and Parkinson’s disease
MicroRNAs (miRNAs) are endogenous small (18–25 nt), single-stranded, non-coding RNAs that play key roles in post-transcriptional gene expression regulation. The expression profiles of miRNAs in biofluids and t...
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Article
Preparation of CaMgSi and Ca7Mg7.25Si14 single phase films and their thermoelectric properties
Ca-Mg-Si films were firstly prepared on (001)Al2O3 substrates by RF-magnetron sputtering method from Mg disc target together with Ca and Si chips. The composition of the deposited films was controlled by adjustin...
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Article
Control of p- and n-type Conduction in Thermoelectric Non-doped Mg2Si Thin Films Prepared by Sputtering Method
A method for controlling the conduction-type in Mg2Si films without do** is investigated. Mg2Si films exhibit p-type conduction after a post-heat treatment up to 500 °C in atmospheric He. However, covering the ...
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Article
Growth of (111)-oriented epitaxial magnesium silicide (Mg2Si) films on (001) Al2O3 substrates by RF magnetron sputtering and their properties
Epitaxial Mg2Si films with (111) orientation were successfully grown at 300 °C on (001) Al2O3 insulating substrates by RF magnetron sputtering method. The optimal conditions for the epitaxial growth were identifi...
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Article
Open AccessMutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome
Clinical diagnosis of progressive supranuclear palsy (PSP) is sometimes difficult because various phenotypes have been identified. Here, we report a mutation in the bassoon (BSN) gene in a family with PSP-like sy...
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Article
Open AccessGenomic copy number variation analysis in multiple system atrophy
Genomic variation includes single-nucleotide variants, small insertions or deletions (indels), and copy number variants (CNVs). CNVs affect gene expression by altering the genome structure and transposable ele...
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Article
Open AccessValidity and reliability of a pilot scale for assessment of multiple system atrophy symptoms
Multiple system atrophy (MSA) is a rare progressive neurodegenerative disorder for which brief yet sensitive scale is required in order for use in clinical trials and general screening. We previously compared ...
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Article
Preparation of Ca-Si Films on (001) Al2O3 Substrates by an RF Magnetron Sputtering Method and Their Electrical Properties
The constituent phases, electrical conductivity, and Seebeck coefficient of Ca-Si films deposited on (001) Al2O3 substrates by a radio frequency magnetron sputtering method using a Mg disk target with Ca and Si c...
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Article
Comparison of Different Symptom Assessment Scales for Multiple System Atrophy
To identify the most sensitive scale for use in clinical trials on multiple system atrophy (MSA), a short and sensitive scale is needed for MSA clinical trials. Potential candidates are the Unified MSA Rating ...
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Article
Open AccessThermally stable dielectric responses in uniaxially (001)-oriented CaBi4Ti4O15 nanofilms grown on a Ca2Nb3O10− nanosheet seed layer
To realize a high-temperature capacitor, uniaxially (001)-oriented CaBi4Ti4O15 films with various film thicknesses were prepared on (100)cSrRuO3/Ca2Nb3O10− nanosheet/glass substrates. As the film thickness decrea...
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Article
Epidemiology of Multiple System Atrophy in Hokkaido, the Northernmost Island of Japan
Multiple system atrophy (MSA) is an intractable neurodegenerative disorder that is characterized by various combinations of autonomic failure, cerebellar ataxia, and parkinsonism. We conducted an epidemiologic...
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Article
Open AccessIdentification of plasma microRNAs as a biomarker of sporadic Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, which leads to the loss of upper and lower motor neurons, with a currently unknown etiology. Specific biomarkers could help in early de...
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Article
Usefulness of 11C-methionine-positron emission tomography for the diagnosis of progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating disease of the brain caused by the JC virus that occurs mainly in immunocompromised patients. The prognosis is very poor. As the les...
