18 Result(s)
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Martin Regensburger
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Article
Open AccessPatients’ and caregivers’ perception of multidimensional and palliative care in amyotrophic lateral sclerosis – protocol of a German multicentre study
Amyotrophic lateral sclerosis (ALS) is an inevitably fatal condition that leads to a progressive loss of physical functioning, which results in a high psychosocial burden and organizational challenges related ...
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Open AccessNeuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients
Biallelic loss of SPG11 function constitutes the most frequent cause of complicated autosomal recessive hereditary spastic paraplegia (HSP) with thin corpus callosum, resulting in progressive multisystem neurodeg...
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Open AccessA reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease
Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at differ...
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Open AccessThe effects of an individualized smartphone-based exercise program on self-defined motor tasks in Parkinson’s disease: a long-term feasibility study
Exercise therapy is considered effective for the treatment of motor impairment in patients with Parkinson’s disease (PD). During the COVID-19 pandemic, training sessions were cancelled and the implementation o...
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Open AccessEconomic evaluation of Motor Neuron Diseases: a nationwide cross-sectional analysis in Germany
Motor Neuron Diseases (MND) are rare diseases but have a high impact on affected individuals and society. This study aims to perform an economic evaluation of MND in Germany.
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Open AccessAutomated assessment of foot elevation in adults with hereditary spastic paraplegia using inertial measurements and machine learning
Hereditary spastic paraplegias (HSPs) cause characteristic gait impairment leading to an increased risk of stumbling or even falling. Biomechanically, gait deficits are characterized by reduced ranges of motio...
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Open AccessClinical benefit of MAO-B and COMT inhibition in Parkinson’s disease: practical considerations
Inhibitors of monoamine oxidase B (MAO-B) and catechol-O-methyltransferase (COMT) are major strategies to reduce levodopa degradation and thus to increase and prolong its effect in striatal dopaminergic neurot...
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Open AccessAberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by aberrant alternative splicing (AS). Nuclear loss and cytoplasmic accumulation of the splicing factor TDP-43 in motor neurons (MN) are hal...
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Open AccessNeuropsychology and MRI correlates of neurodegeneration in SPG11 hereditary spastic paraplegia
SPG11-linked hereditary spastic paraplegia is characterized by multisystem neurodegeneration leading to a complex clinical and yet incurable phenotype of progressive spasticity and weakness. Severe cognitive symp...
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Open AccessDeep Brain Stimulation, Stereotactic Radiosurgery and High-Intensity Focused Ultrasound Targeting the Limbic Pain Matrix: A Comprehensive Review
Chronic pain (CP) represents a socio-economic burden for affected patients along with therapeutic challenges for currently available therapies. When conventional therapies fail, modulation of the affective pai...
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Open AccessLong-term course of anterior spinal cord herniation presenting with an upper motor neuron syndrome: case report illustrating diagnostic and therapeutic implications
Anterior spinal cord herniation (aSCH) is a rare cause of myelopathy which may present as pure motor syndrome and mimic other degenerative diseases of the spinal cord. In slowly progressive cases, diagnosis ma...
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Open AccessNeed for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium
Genetic integrity of induced pluripotent stem cells (iPSCs) is essential for their validity as disease models and for potential therapeutic use. We describe the comprehensive analysis in the ForIPS consortium:...
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Open AccessOligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice
In the adult mammalian hippocampus, new neurons are constantly added to the dentate gyrus. Adult neurogenesis is impaired in several neurodegenerative mouse models including α-synuclein (a-syn) transgenic mice...
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Open AccessEndogenous endophthalmitis complicating Streptococcus equi subspecies zooepidemicus meningitis: a case report
Streptococcus equi subspecies zooepidemicus (Streptococcus zooepidemicus) is a rare cause of meningitis in humans. Humans mainly get infected by contact with an animal source or by ingestion of...
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Open AccessPropofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia
Mild therapeutic hypothermia is an increasingly recognised treatment option to reduce perihemorrhagic edema in severe intracerebral hemorrhage.
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Article
Adult neurogenesis in Parkinson’s disease
Parkinson’s disease (PD), the second most common neurodegenerative disorder, affects 1–2 % of humans aged 60 years and older. The diagnosis of PD is based on motor symptoms such as bradykinesia, rigidity, trem...
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Open AccessImpaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder linked to expanded CAG-triplet nucleotide repeats within the huntingtin gene. Intracellular huntingtin aggregates are present in neuro...
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Asymptotische Darstellung und Lage der Nullstellen spezieller ganzer Funktionen (Exponentialsummen)
