14 Result(s)
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Johannes C. M. Schlachetzki
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Article
Open AccessGenomic Mosaicism of the Brain: Origin, Impact, and Utility
Genomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic mutations. Traditionally, research focused on the impact of genomic mosaicism on clinical phenotype...
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Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain
Debate remains around the anatomical origins of specific brain cell subtypes and lineage relationships within the human forebrain1–7. Thus, direct observation in the mature human brain is critical for a complete ...
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Open AccessAPOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
Several genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1. However, the relationship between lipid metabo...
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Publisher Correction: Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
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Immune mechanisms of depression in rheumatoid arthritis
Depression is a common and disabling comorbidity in rheumatoid arthritis that not only decreases the likelihood of remission and treatment adherence but also increases the risk of disability and mortality in p...
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Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
People living with HIV are affected by the chronic consequences of neurocognitive impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve health and extend life. Furthermore,...
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Somatic mosaicism reveals clonal distributions of neocortical development
The structure of the human neocortex underlies species-specific traits and reflects intricate developmental programs. Here we sought to reconstruct processes that occur during early development by sampling adu...
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Nuclei isolation of multiple brain cell types for omics interrogation
We present a nuclei isolation protocol for genomic and epigenomic interrogation of multiple cell type populations in the human and rodent brain. The nuclei isolation protocol allows cell type-specific profilin...
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Open AccessLong-term course of anterior spinal cord herniation presenting with an upper motor neuron syndrome: case report illustrating diagnostic and therapeutic implications
Anterior spinal cord herniation (aSCH) is a rare cause of myelopathy which may present as pure motor syndrome and mimic other degenerative diseases of the spinal cord. In slowly progressive cases, diagnosis ma...
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Open AccessAuthor Correction: A monocyte gene expression signature in the early clinical course of Parkinson’s disease
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Sensor-based gait analysis of individualized improvement during apomorphine titration in Parkinson’s disease
Mobile, sensor-based gait analysis in Parkinson’s disease (PD) facilitates the objective measurement of gait parameters in cross-sectional studies. Besides becoming outcome measures for clinical studies, the a...
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Open AccessA monocyte gene expression signature in the early clinical course of Parkinson’s disease
Microglia are the main immune cells of the brain and express a large genetic pattern of genes linked to Parkinson’s disease risk alleles. Monocytes like microglia are myeloid-lineage cells, raising the questio...
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α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy
Multiple system atrophy (MSA) is a rare atypical parkinsonian disorder characterized by a rapidly progressing clinical course and at present without any efficient therapy. Neuropathologically, myelin loss and ...
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Open AccessOligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?
Oligodendrocytes, the myelinating cells of the central nervous system, mediate rapid action potential conduction and provide trophic support for axonal as well as neuronal maintenance. Their progenitor cell po...
