4 Result(s)

Article

Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma

Despite advancements in understanding the pathophysiology of Multiple Myeloma (MM), the cause of rapid progressing disease in a subset of patients is still unclear. MM’s progression is facilitated by complex i...

William Pilcher, Beena E. Thomas, Swati S. Bhasin… in npj Genomic Medicine (2023)

Article

Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy

Barbara Muz, Feda Azab, Mark Fiala, Justin King, Daniel Kohnen… in Blood Cancer Journal (2019)

Article

A multiple myeloma-specific capture sequencing platform discovers novel translocations and frequent, risk-associated point mutations in IGLL5

Multiple myeloma (MM) is a disease of copy number variants (CNVs), chromosomal translocations, and single-nucleotide variants (SNVs). To enable integrative studies across these diverse mutation types, we devel...

Brian S. White, Irena Lanc, Julie O’Neal, Harshath Gupta… in Blood Cancer Journal (2018)

Article

Personalization of cancer treatment using predictive simulation

The personalization of cancer treatments implies the reconsideration of a one-size-fits-all paradigm. This move has spawned increased use of next generation sequencing to understand mutations and copy number a...

Nicole A Doudican, Ansu Kumar, Neeraj Kumar Singh… in Journal of Translational Medicine (2015)