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Article
Open AccessRespiratory effects of oral mitragynine and oxycodone in a rodent model
Kratom derives from Mitragyna speciosa (Korth.), a tropical tree in the genus Mitragyna (Rubiaceae) that also includes the coffee tree. Kratom leaf powders, tea-like decoctions, and commercial extracts are taken ...
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Article
Correction to: Identification of ∆9-tetrahydrocannabinol (THC) impairment using functional brain imaging
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Article
Combined effect of alcohol and cannabis on simulated driving
With alcohol and cannabis remaining the most commonly detected drugs in seriously and fatally injured drivers, there is a need to understand their combined effects on driving.
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Article
Open AccessIdentification of ∆9-tetrahydrocannabinol (THC) impairment using functional brain imaging
The primary cannabinoid in cannabis, Δ9-tetrahydrocannabinol (THC), causes intoxication and impaired function, with implications for traffic, workplace, and other situational safety risks. There are currently ...
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Reference Work Entry In depth
Cannabinoids Pharmacology, Abuse, and Addiction
Cannabis has a long history of therapeutic use and misuse. Δ-9-tetrahydrocannabinol (THC) was identified as the principle psychoactive component of cannabis in 1965. For the next two decades, cannabis research...
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Article
Pharmacokinetic, behavioral, and brain activity effects of Δ9-tetrahydrocannabinol in adolescent male and female rats
Δ9-tetrahydrocannabinol (THC) is the intoxicating constituent of cannabis and is responsible for the drug’s reinforcing effects. Retrospective human studies suggest that cannabis use during adolescence is linked....
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Article
Nicotinic receptor modulation of the default mode network
Previous neuroimaging studies of cognition involving nicotinic acetylcholine receptor (nAChR) agonist administration have repeatedly found enhanced task-induced deactivation of regions of the default mode netw...
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Article
Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome
Cigarette smoking during pregnancy is a major public health concern. While there are well-described consequences in early child development, there is very little known about the effects of maternal smoking on ...
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Article
Prenatal Tobacco and Cannabis Exposure: Associations with Cortisol Reactivity in Early School Age Children
The study examined the association between prenatal tobacco or co-exposure to tobacco and cannabis and children’s cortisol reactivity at kindergarten age and the role of child sex, maternal negative mood (depr...
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Article
Open AccessEffects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: a randomized, double-blind, placebo-controlled, human laboratory study
As perspectives on cannabis continue to shift, understanding the physiological and behavioral effects of cannabis use is of paramount importance. Previous data suggest that cannabis use influences food intake,...
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Chapter
Cannabis
In the past 35 years, scientists discovered the endogenous cannabinoid system that mediates critical human physiological functions including planning and control of movement, emotional behavior, cognitive func...
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Article
Measuring Within-Individual Cannabis Reduction in Clinical Trials: a Review of the Methodological Challenges
Cannabis abstinence, traditionally, is the primary outcome in cannabis use disorder (CUD) treatment trials. Due to the changing legality of cannabis, patient goals, and preliminary evidence suggesting that ind...
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Article
NBOMe instability in whole blood
The stability of NBOMes, potent new psychoactive substances, in whole blood was studied over 180 days.
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Article
Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry
The present study aims to recommend appropriate urinary marker metabolites for documenting EG-018 consumption by investigating its metabolism in human hepatocytes.
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Article
Quantification of ethyl glucuronide, ethyl sulfate, nicotine, and its metabolites in human fetal liver and placenta
Tobacco and alcohol use during pregnancy is serious public health concerns and result in adverse developmental outcomes. Identifying in utero exposure is often achieved through meconium analysis or via materna...
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Article
Changes in marijuana use symptoms and emotional functioning over 28-days of monitored abstinence in adolescent marijuana users
Advancing marijuana prevention and intervention efforts are important given the decreasing perception of harm among adolescents and increasing marijuana legalization.
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Article
Erratum to: Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells
During manuscript proofing, the following sentence was not deleted in the section “Results” at the end of the paragraph: “Both male and female hepatocytes responded in a similar fashion to cotinine, whereas ma...
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Article
Open AccessModelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells
The liver is a dynamic organ which is both multifunctional and highly regenerative. A major role of the liver is to process both endo and xenobiotics. Cigarettes are an example of a legal and widely used drug ...
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Article
In vitro metabolism of new synthetic cannabinoid SDB-006 in human hepatocytes by high-resolution mass spectrometry
The drug abuse epidemic within the United States remains one of the nation’s most serious social challenges, especially among adolescents and young adults. Novel psychoactive substances continuously emerge int...
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Article
Open AccessIdentification of New Synthetic Cannabinoid ADB-CHMINACA (MAB-CHMINACA) Metabolites in Human Hepatocytes
ADB-CHMINACA (MAB-CHMINACA) is a new synthetic cannabinoid with high potency and many reported adverse events and fatalities. The drug is currently scheduled in several countries in Europe and the USA. Analyti...
