3 Result(s)
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Maria Thomas
Cell Biology
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Article
Open AccessEthanol sensitizes hepatocytes for TGF-β-triggered apoptosis
Alcohol abuse is a global health problem causing a substantial fraction of chronic liver diseases. Abundant TGF-β—a potent pro-fibrogenic cytokine—leads to disease progression. Our aim was to elucidate the cro...
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Article
Open AccessTargeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained
DNA methylation and histone 3 lysine 9 (H3K9) methylation are considered as epigenetic marks that can be inherited through cell divisions. To explore the functional consequences and stability of these modifica...
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Chapter
RNA Interference in Haematopoietic and Leukaemic Cells
The haematopoietic system is currently the best characterized mammalian differentiation system. On the one hand, pathologic disturbance of the differentiation programmes results in the development of haemopoie...
