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Article
Cannabinoids and gene expression during brain development
Cannabis is the most commonly used illicit drug in western societies, in particular among young people. It is consumed even by women during pregnancy and lactation, which result in a variety of disturbances in...
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Article
Loss of cannabinoid CB1 receptors in the basal ganglia in the late akinetic phase of rats with experimental Huntington’s disease
We have recently examined the status of the endocannabinoid transmission in the basal ganglia in Huntington’s disease (HD) using a rat model generated by bilateral intrastriatal injections of 3-nitropropionic ...
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Article
Changes in prodynorphin and POMC gene expression in several brain regions of rat fetuses prenatally exposed to Δ-tetrahydrocannabinol
Recently, we demonstrated that prenatal Δ-tetrahydrocannabinol (Δ9-THC) exposure alters proenkephalin mRNA levels in several brain regions of rat fetuses. In the present study, we analyzed mRNA levels of the two ...
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Article
Endogenous polyamines modulate Ca2+ channel activity in guinea-pig intestinal smooth muscle
The polyamines spermine and spermidine inhibit L-type Ca2+ channels in whole-cell recordings from guinea-pig ileum cells (Gomez and Hellstrand, Pflügers Arch, 430:501–507, 1995 [4]). To study whether they modula...
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Article
Identification of a novel inflammation-protective locus in the Fischer rat
Inbred LEW/N rats are relatively susceptible, while histocompatible inbred F344/N rats are relatively resistant to development of a wide variety of inflammatory diseases in response to a range of pro-inflamma...
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Article
Effects of polyamines on voltage-activated calcium channels in guinea-pig intestinal smooth muscle
Effects of polyamines on the spontaneous mechanical and electrical activity of guinea-pig intestinal smooth muscle were studied. Spermine and spermidine inhibited action potential generation and contractions, ...