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  1. No Access

    Article

    Gene structure and chromosomal map** of the rat smooth muscle calponin gene

    Smooth muscle cells (SMC) express a battery of lineage-restricted genes whose encoded proteins impart the unique contractile phenotype that characterizes this muscle type. While the encoded function of many S...

    Marcelo A. Nobrega, Masahide Shiozawa, George Koike, Howard J. Jacob… in Mammalian Genome (2000)

  2. No Access

    Article

    A rat genetic linkage map including 67 new microsatellite markers

    Hossein Fakhrai-Rad, Hong Jiao, Luo-Sheng Li, Anna Glaser, George Koike… in Mammalian Genome (1999)

  3. No Access

    Article

    BB rat diabetes susceptibility and body weight regulation genes colocalize on Chromosome 2

    The genetic etiology of Type 1 (insulin-dependent) diabetes mellitus is complicated by the apparent presence of several diabetes susceptibility genetic regions. Type 1 diabetes in the inbred BioBreeding (BB) ...

    Lindy S. Klaff, George Koike, Jianjie Jiang, Yanling Wang, Sabine Bieg… in Mammalian Genome (1999)

  4. No Access

    Article

    Identification of a novel inflammation-protective locus in the Fischer rat

    Inbred LEW/N rats are relatively susceptible, while histocompatible inbred F344/N rats are relatively resistant to development of a wide variety of inflammatory diseases in response to a range of pro-inflamma...

    Samuel Listwak, Ruth M. Barrientos, George Koike, Soumitra Ghosh… in Mammalian Genome (1999)

  5. No Access

    Article

    Map** and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima Fatty rat

    The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, non-insulin-dependent diabetes mellitus (NIDDM) in humans. We have previously reported four quantitative trait loci (QTLs) ...

    Suwen Wei, Kaichun Wei, Daniel H. Moralejo, Tomoe Ogino, George Koike… in Mammalian Genome (1999)

  6. No Access

    Article

    Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases

    George Koike, Jean-Daniel Chiche, Masahide Shiozawa, Jason S. Simon… in Mammalian Genome (1999)

  7. No Access

    Article

    Sinus histiocytosis with massive lymphadenopathy: A case of multiple dural involvement

    An exeptional case of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) arising from the meninges in a 60-year-old Japanese man is presented. Computerized tomographic scans and magnetic ...

    Keiichi Sakai, George Koike, Kyoji Seguchi, Yoichi Nakazato in Brain Tumor Pathology (1998)

  8. No Access

    Article

    Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution

    In order to generate anchor points connecting the rat cytogenetic and genetic maps, the cytogenetic position of 62 rat markers (including 55 genes) already localized genetically was determined by fluorescence...

    Claude Szpirer, Josiane Szpirer, Pascale Van Vooren, Fadel Tissir… in Mammalian Genome (1998)

  9. No Access

    Article

    An integrated genetic linkage map of the laboratory rat

    The laboratory rat, Rattus novegicus, is a major model system for physiological and pathophysiological studies, and since 1966 more than 422,000 publications describe biological studies on the rat (NCBI/Medline)...

    Donna M. Brown, Tara C. Matise, George Koike, Jason S. Simon… in Mammalian Genome (1998)

  10. No Access

    Article

    Map** of the rat SM22 gene to Chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy

    George Koike, Joseph M. Miano, Pascale Vanvooren, Masahide Shiozawa… in Mammalian Genome (1998)

  11. No Access

    Chapter

    Hypertension

    The explosion of genetic markers and analytical techniques in the field of molecular genetics makes the dissection of the genes conveying risk for multifactorial (multiple genes and gene—environment interactio...

    George Koike, Howard J. Jacob in Principles of Molecular Medicine (1998)

  12. No Access

    Article

    Strain-specific deletions in exon 10 of rat K-kininogen and T1-kininogen genes allow map** of both genes to rat Chromosome 11

    Eugenie L. Harris, Murray R. Grigor, Brendan A. Innes… in Mammalian Genome (1997)

  13. No Access

    Article

    Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci

    Claude Szpirer, Josiane Szpirer, Pascole Vanvooren, Michèle Rivière… in Mammalian Genome (1997)

  14. No Access

    Article

    A genetic linkage map of the laboratory rat, Rattus norvegicus

    We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms ...

    Howard J. Jacob, Donna M. Brown, Ruth K. Bunker, Mark J. Daly… in Nature Genetics (1995)