8 Result(s)
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Isabel Lastres-Becker
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Open Accessα-Synuclein Induces the GSK-3-Mediated Phosphorylation and Degradation of NURR1 and Loss of Dopaminergic Hallmarks
In Parkinson’s disease, the dysfunction of the dopaminergic nigrostriatal tract involves the loss of function of dopaminergic neurons of the substantia nigra pars compacta followed by death of these neurons. T...
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Open AccessNRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling
The transcription factor NRF2 is a master regulator of cellular antioxidant and detoxification responses, but it also regulates other processes such as autophagy and pluripotency. In human embryonic stem cells...
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Open AccessNew alternative splicing variants of the ATXN2 transcript
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder with progressive degeneration of cerebellar Purkinje cells and selective loss of neurons in the brainstem. This neurodegenerative disorder...
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Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells
Microglial cells are essential mediators of neuroinflammatory processes involved in several pathologies. Moreover, the chemokine fractalkine (CX3CL1) is essential in the crosstalk between neurons and microglia...
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Open AccessAtaxin-2 Modulates the Levels of Grb2 and Src but Not Ras Signaling
Ataxin-2 (ATXN2) is implicated mainly in mRNA processing. Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD...
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Spinocerebellar ataxia 2 (SCA2)
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited, neurodegenerative disease. It can manifest either with a cerebellar syndrome or as Parkinson’s syndrome, while later stages involve ma...
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Loss of cannabinoid CB1 receptors in the basal ganglia in the late akinetic phase of rats with experimental Huntington’s disease
We have recently examined the status of the endocannabinoid transmission in the basal ganglia in Huntington’s disease (HD) using a rat model generated by bilateral intrastriatal injections of 3-nitropropionic ...
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Unilateral 6-Hydroxydopamine Lesions of Nigrostriatal Dopaminergic Neurons Increased Cannabinoid CB1 Receptor mRNA Levels in the Rat Striatum: Possible Therapeutic Implications
It has been recently suggested that the effects of cannabinoids on motor behavior might be different in rats with lesions of the basal ganglia than controls. In the present study, we have examined the possible...
