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Living Reference Work Entry In depth
MPTP: Advances from an Evergreen Neurotoxin
Since its discovery in 1976, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models in rodents and nonhuman primates have continuously renewed to keep up with progresses of Parkinson’s disease (PD) researc...
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Reference Work Entry In depth
MPTP: Advances from an Evergreen Neurotoxin
Since its discovery in 1976, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models in rodents and nonhuman primates have continuously renewed to keep up with progresses of Parkinson’s disease (PD) researc...
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Article
Open AccessThree-dimensional vascular microenvironment landscape in human glioblastoma
The cellular complexity of glioblastoma microenvironments is still poorly understood. In-depth, cell-resolution tissue analyses of human material are rare but highly necessary to understand the biology of this...
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Article
Open AccessCold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells
Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both apoptosis and necrosis have been implicated as th...
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Chapter
The MTOC/Golgi Complex at the T-Cell Immunological Synapse
T cells effectively explore the tissue in search for antigens. When activated, they dedicate a big amount of energy and resources to arrange a complex structure called immunological synapse (IS), containing a ...
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Article
Open AccessCold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death
Gold nanoparticles (AuNP) have potential as both diagnostic and therapeutic vehicles. However, selective targeting and uptake in cancer cells remains challenging. Cold atmospheric plasma (CAP) can be combined ...
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Protocol
Studying the T Cell-Astrocyte Immune Synapse
In this chapter, we describe the technical details to visualize and analyze effector immunological synapses between T cells and astrocytes in the brain with high-resolution confocal imaging. This procedure is ...
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Reference Work Entry In depth
MPTP: Advances from an Evergreen Neurotoxin
Since its discovery in 1976, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models in rodents and nonhuman primates have continuously renewed to keep up with progresses of Parkinson’s disease (PD) researc...
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Article
Open AccessROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo
The role of microglial motility in the context of adult neurodegeneration is poorly understood. In the present work, we investigated the microanatomical details of microglia-neuron interactions in an experimen...
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Chapter
Increase of Secondary Processes of Microglial and Astroglial Cells After MPTP-Induced Degeneration in Substantia Nigra Pars Compacta of Non Human Primates
Nigral dopaminergic areas from Parkinsonian patients show an increase of reactive astrocytes and active microglia. The reaction of these two cell types is a clear evidence of inflammatory response associated w...
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Chapter
Inflammatory Response in Parkinsonism
Inflammatory responses have been proposed as important factors in dopaminergic neuro-degeneration in Parkinsonism. Increasing evidence suggests that the alteration of the glial microenvironment induced by neur...
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Chapter and Conference Paper
Modulatory Role of NK1 Receptors in the Basal Ganglia. Studies in NK1-/- Mice
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Article
Parkinson's disease and inflammatory changes
In 1988 McGeer and colleagues (Neurology 38, 1285–91) observed an activation of the microglia in substantia nigrapars compacta (SNpc) and striatum of brains from patients with Parkinson's disease. In the years th...
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Article
Functional anatomy of thalamus and basal ganglia
Thalamus.The human thalamus is a nuclear complex located in the diencephalon and comprising of four parts (the hypothalamus, the epythalamus, the ventral thalamus, and the dorsal thalamus). The t...
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Chapter
Blood Vessels And Neurodegeneration In Parkinson’s Disease
Parkinson’s disease (PD) is characterised by a differential vulnerability of dopaminergic neurons in the mesencephalon. The loss is severe in the substantia nigra pars compacta (SNpc) (85-90%), intermediate in th...
