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  1. No Access

    Article

    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    Christopher Newton-Cheh and colleagues report genome-wide association analyses for QT interval, an electrocardiographic measure reflecting myocardial repolarization, in 100,000 individuals. They identify 35 lo...

    Dan E Arking, Sara L Pulit, Lia Crotti, Pim van der Harst… in Nature Genetics (2014)

  2. No Access

    Chapter

    Role of Striatal A2A Receptor Subpopulations in Neurological Disorders

    A very significant density of adenosine A2A receptors (A2AR) is present in the striatum, where they are preferentially localized postsynaptically in enkephalinergic-GABAergic-medium spiny neurons (enkephalinergic...

    Sergi Ferré, César Quiroz, Marco Orrú, Xavier Guitart, Seema Gulyani… in Adenosine (2013)

  3. No Access

    Article

    Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

    Joshua Bis, Christopher O'Donnell and colleagues report a meta-analysis of genome-wide association studies from the CHARGE Consortium that identifies loci associated with carotid intima media thickness and pla...

    Joshua C Bis, Maryam Kavousi, Nora Franceschini, Aaron Isaacs… in Nature Genetics (2011)

  4. No Access

    Article

    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

    Paul Elliott, Martin Tobin, Cornelia van Duijn and colleagues report a genome-wide association study for pulse pressure and mean arterial pressure, identifying six new loci influencing these two traits.

    Louise V Wain, Germaine C Verwoert, Paul F O'Reilly, Gang Shi… in Nature Genetics (2011)

  5. Article

    Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    Nat. Genet. 42, 105–116 (2010); published online 17 January 2010; corrected after print 26 March 2010 In the version of this article initially published, there were several errors in the author affiliations. T...

    Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena… in Nature Genetics (2010)

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  6. No Access

    Article

    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly di...

    Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena… in Nature Genetics (2010)

  7. No Access

    Article

    Common variants at ten loci modulate the QT interval duration in the QTSCD Study

    Arne Pfeufer, Aravinda Chakravarti and colleagues from the QTSCD consortium report genetic associations influencing the QT interval duration, a measure of cardiac repolarization which is a risk factor for sudd...

    Arne Pfeufer, Serena Sanna, Dan E Arking, Martina Müller, Vesela Gateva… in Nature Genetics (2009)

  8. No Access

    Article

    Variants in MTNR1B influence fasting glucose levels

    Gonçalo Abecasis and colleagues report associations with fasting plasma glucose levels in a collection of ten genome–wide association scans from the MAGIC consortium. They find variants in the gene encoding me...

    Inga Prokopenko, Claudia Langenberg, Jose C Florez, Richa Saxena… in Nature Genetics (2009)

  9. No Access

    Article

    Effects of tryptophan deficiency on prepulse inhibition of the acoustic startle in rats

    Serotonin (5-HT) plays a key role in the pathophysiology of psychotic disorders, presumably through a modulation of dopamine (DA) transmission. Reduction of 5-HT signaling has been suggested to enhance dopamin...

    Marco Bortolato, Roberto Frau, Marco Orrù, Maria Collu… in Psychopharmacology (2008)

  10. No Access

    Article

    Activation of GABAB receptors reverses spontaneous gating deficits in juvenile DBA/2J mice

    Gamma-amino-butyric acid (GABA)B receptors play a key role in the pathophysiology of psychotic disorders. We previously reported that baclofen, the prototypical GABAB agonist, elicits antipsychotic-like effects i...

    Marco Bortolato, Roberto Frau, Marco Orrù, A. Paola Piras, Mauro Fà… in Psychopharmacology (2007)

  11. No Access

    Article

    The CB receptor agonist WIN 55,212-2 fails to elicit disruption of prepulse inhibition of the startle in Sprague-Dawley rats

    A growing evidentiary body indicates cannabinoid exposure is conducive to cognitive impairment and psychotic phenomena in vulnerable individuals. In this respect, recent studies have displayed controversial re...

    Marco Bortolato, Gian Nicola Aru, Roberto Frau, Marco Orrù… in Psychopharmacology (2005)

  12. No Access

    Article

    Baclofen reverses the reduction in prepulse inhibition of the acoustic startle response induced by dizocilpine, but not by apomorphine

    Since baclofen, the prototypical GABAB receptor agonist, is known to reduce the activity of dopaminergic mesolimbic neurons, a putative antipsychotic property of this compound has been suggested, but the evidence...

    Marco Bortolato, Roberto Frau, Gian Nicola Aru, Marco Orrù… in Psychopharmacology (2004)