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Article
Neurochirurgia degli adenomi ipofisari ACTH secernenti
Il trattamento neurochirurgico è la terapia di prima linea della malattia di Cushing (CD). Lo scopo principale della chirurgia è la remissione della malattia. Nei casi in cui non è possibile raggiungere il ris...
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Article
High prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma
Vertebral fractures (VFs), the hallmark of skeletal fragility, have been reported as an emerging complication in patients with pituitary diseases associated with hormonal excess and/or deficiency, independentl...
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Chapter
Craniopharyngioma in Pediatrics and Adults
Craniopharyngiomas are rare malignancies of dysembryogenic origin, involving areas. These low-grade, epithelial tumors account for two main histological craniopharyngioma craniopharyngioma), which diff...
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Chapter
Benign and Malignant Tumors of the Pituitary Gland
tumors represent approximately 10–15% of and the most of region. Among are the widespread accounting for more than 80%. Recently, the fourth edition (WHO) 2017 classified pituitary tumors focusing o...
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Article
Open AccessA conformational switch controlling the toxicity of the prion protein
Prion infections cause conformational changes of the cellular prion protein (PrPC) and lead to progressive neurological impairment. Here we show that toxic, prion-mimetic ligands induce an intramolecular R208-H14...
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Article
Comparison between extended transsphenoidal and transcranial surgery for craniopharyngioma: focus on hypothalamic function and obesity
Patients suffering from craniopharyngiomas currently have good survival rates, but long-term sequelae, such as development of obesity, worsen their quality of life. Optimal treatment is still controversial and...
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Article
Bone and body composition analyses by DXA in adults with GH deficiency: effects of long-term replacement therapy
The effects of growth hormone (GH) replacement on bone mass and body composition in adult with GH deficiency (AGHD) are still debated with regard to their persistence in the long term. Moreover, the impact of ...
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Article
Open AccessRepeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system
Widespread use of silver in its different forms raises concerns about potential adverse effects after ingestion, the main exposure route for humans. The aim of this study was to investigate in CD-1 (ICR) male ...
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Article
Verso una migliore definizione del concetto di adenoma ipofisario aggressivo
Gli adenomi ipofisari rappresentano un problema clinico di frequente presentazione nella pratica endocrinologica. Nella maggior parte dei casi si comportano come lesioni a bassa velocità di crescita, non invas...
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Article
The optimal numerosity of the referral population of pituitary tumors centers of excellence (PTCOE): A surgical perspective
Surgical experience is of paramount importance to reach therapeutic success and minimize operative complications. In the field of pituitary surgery, this led to the concept of Pituitary Center of Excellence (P...
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Article
Multidisciplinary management of acromegaly: A consensus
The 13th Acromegaly Consensus Conference was held in November 2019 in Fort Lauderdale, Florida, and comprised acromegaly experts including endocrinologists and neurosurgeons who considered optimal approaches f...
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Article
Long-course temozolomide in aggressive pituitary adenoma: real-life experience in two tertiary care centers and review of the literature
Aggressive pituitary adenomas (APAs) and pituitary carcinomas (PCs) are challenging for their invasive nature, resistance to treatment and recurrences. Temozolomide (TMZ) is used with benefit and well-tolerate...
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Article
Pituitary adenomas in elderly patients: clinical and surgical outcome analysis in a large series
The increased life expectancy in the general population is causing rapid growth of the number of elderly patients. Pituitary adenomas (PAs) are one of those tumors whose incidence increases with age. Pituitary...
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Article
Sublabial transsphenoidal microsurgical technique to treat congenital transsphenoidal encephalocele: a technical note
Encephalocele is a rare malformation consisting in herniation of cranial contents through a cranial defect. A transsphenoidal location is uncommon, representing 5% of all basal encephaloceles. The surgical tre...
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Article
Safety and efficacy of multisession gamma knife radiosurgery for residual or recurrent pituitary adenomas
To define the efficacy and complications of multisession Gamma Knife radiosurgery (MGKRS) delivered in three consecutive sessions for the treatment of residual or recurrent pituitary adenomas (PAs).
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Article
Pretreatment with somatostatin analogs does not affect the anesthesiologic management of patients with acromegaly
Acromegaly may be associated with an increased risk of complex intraoperative management and anesthetic complications. No study addressed whether pretreatment with somatostatin receptor ligands (SRLs) affects ...
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Article
Clinical characteristics and surgical outcome in USP8-mutated human adrenocorticotropic hormone-secreting pituitary adenomas
somatic mutations in the ubiquitin-specific protease 8 (USP8) gene have recently been described in patients with Cushing’s disease (CD). The aim of the study is to verify whether USP8 mutation may predict early a...
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Article
Single fraction and multisession Gamma Knife radiosurgery for craniopharyngioma
The optimal management of residual or recurring craniopharyngioma is still a matter of debate even though adjuvant radiation therapy plays a crucial role. Aim of our study is to report the results of single fr...
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Article
Publisher Correction: Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
In the HTML version of this article initially published, the name of author Diletta Di Mitri was miscoded in the XML such that Di was included as part of the given name instead of the family name. The error ha...
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Article
IL-23 secreted by myeloid cells drives castration-resistant prostate cancer
Patients with prostate cancer frequently show resistance to androgen-deprivation therapy, a condition known as castration-resistant prostate cancer (CRPC). Acquiring a better understanding of the mechanisms th...
