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Article
Open AccessUncommon adrenal rest tumors and massive adrenal enlargement in adult with congenital adrenal hyperplasia mimicking metastasis from pleomorphic sarcoma
Congenital adrenal hyperplasia (CAH) encompassed a bunch of autosomal recessive disorders characterized by impaired cortisol levels due to an enzymatic deficiency in steroid synthesis. In adult male patients w...
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Article
Open AccessHeat inactivation of SARS-CoV 2 enabled the measurement of salivary cortisol during COVID-19 pandemic
Salivary cortisol has become an essential tool in the management of cortisol-related disease. In 2020 the sudden outbreak of COVID-19 pandemic caused several concerns about the use of saliva, due to the risk o...
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Article
Genetica degli adenomi ACTH secernenti: mutazioni somatiche
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Article
Genetica degli adenomi ACTH secernenti: mutazioni germinali
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Relacorilant, un nuovo bloccante selettivo del recettore dei glucocorticoidi
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Open AccessComplications and mortality of Cushing’s disease: report on data collected over a 20-year period at a referral centre
Cushing’s disease (CD) is rare condition burdened by several systemic complications correlated to higher mortality rates. The primary goal of clinicians is to achieve remission, but it is unclear if treatment ...
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Article
La transizione del paziente con sindrome adreno-genitale da difetto di 21-idrossilasi
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Article
Open AccessGlucocorticoid excess and COVID-19 disease
The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing high and rapid morbidity and mortality. Immune system response plays...
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Article
Open AccessAnastrozole as add-on therapy for cabergoline-resistant prolactin-secreting pituitary adenomas: real-life experience in male patients
Prolactin-secreting adenoma (PRLoma) can present as large and invasive neoplasm, with increased markers of cellular proliferation. First-line approach is Dopamine Agonists (DAs) treatment; however, DA-resistan...
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Article
Open AccessLesioni ipofisarie nel Carney Complex
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Article
Approccio al paziente con Pseudo-Cushing
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Article
Open AccessTromboprofilassi nel paziente con sindrome di Cushing
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La gestione dei carriers nella iperplasia bilaterale surrenalica ARMC5 mutata
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Open AccessClinical presentation and management of acromegaly in elderly patients
Acromegaly is a rare disease with a peak of incidence in early adulthood. However, enhanced awareness of this disease, combined with wide availability of magnetic resonance imaging (MRI), has increased the dia...
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Article
Is pasireotide-induced diabetes mellitus predictable? A pilot study on the effect of a single dose of pasireotide on glucose homeostasis
Pasireotide (PAS) is an effective treatment for Cushing’s disease (CD) but its use is burdened by an associated high incidence of diabetes mellitus (DM). The aim of this study was to examine the effect of a si...
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Article
Pituitary-adrenal axis and peripheral cortisol metabolism in obese patients
A close relationship between adiposity and increased cortisol levels is well established in patients with endogenous hypercortisolism. Nevertheless, hypothalamic-pituitary-adrenal (HPA) axis regulation in over...
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Article
Long-course temozolomide in aggressive pituitary adenoma: real-life experience in two tertiary care centers and review of the literature
Aggressive pituitary adenomas (APAs) and pituitary carcinomas (PCs) are challenging for their invasive nature, resistance to treatment and recurrences. Temozolomide (TMZ) is used with benefit and well-tolerate...
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Article
Consideration on TMPRSS2 and the risk of COVID-19 infection in Cushing’s syndrome
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Article
The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes
The glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone produced in the gastrointestinal tract in response to nutrients. GIP has a variety of effects on different systems, including the p...
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Hypertension in Cushing’s Syndrome
Secondary hypertension is not uncommon in patients with endocrine diseases. Among them, prolonged elevated cortisol level (Cushing’s syndrome, CS) is one of the most complex to diagnose and treat.
