-
Article
Open AccessA conformational switch controlling the toxicity of the prion protein
Prion infections cause conformational changes of the cellular prion protein (PrPC) and lead to progressive neurological impairment. Here we show that toxic, prion-mimetic ligands induce an intramolecular R208-H14...
-
Article
Open AccessAuthor Correction: Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions
-
Article
Open AccessBrain aging is faithfully modelled in organotypic brain slices and accelerated by prions
Mammalian models are essential for brain aging research. However, the long lifespan and poor amenability to genetic and pharmacological perturbations have hindered the use of mammals for dissecting aging-regul...
-
Article
Open AccessThe Epidemiology of Persons Living with Fontan in 2020 and Projections for 2030: Development of an Epidemiology Model Providing Multinational Estimates
Fontan surgery is a palliative procedure performed in children with a functionally univentricular heart. Improvements in surgical technique over the past 30 years have increased life expectancy in this rare po...
-
Article
Open AccessPHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice
Recently, several genome-wide association studies identified PHACTR1 as key locus for five diverse vascular disorders: coronary artery disease, migraine, fibromuscular dysplasia, cervical artery dissection and hy...
-
Article
Open AccessThe biological function of the cellular prion protein: an update
The misfolding of the cellular prion protein (PrPC) causes fatal neurodegenerative diseases. Yet PrPC is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary eli...
-
Article
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6
The cellular prion protein PrPC promotes peripheral myelin homeostasis by acting on a G protein-coupled receptor to increase levels of cyclic AMP in Schwann cells.
