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  1. Article

    Open Access

    Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation

    Severe COVID-19 is characterized by an increase in the number and changes in the function of innate immune cells including neutrophils. However, it is not known how the metabolome of immune cells changes in pa...

    Yafeng Li, Jessica S. Hook, Qing Ding, Xue **ao, Stephen S. Chung… in Nature Communications (2023)

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  2. Article

    Open Access

    Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury

    Chronic kidney diseases and acute kidney injury are mechanistically distinct kidney diseases. While chronic kidney diseases are associated with podocyte injury, acute kidney injury affects renal tubular epithe...

    Kamalika Mukherjee, Changkyu Gu, Agnieszka Collins, Marcel Mettlen… in Nature Communications (2022)

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  3. No Access

    Article

    Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein

    The dynamin GTPase is known to bundle actin filaments, but the underlying molecular mechanism and physiological relevance remain unclear. Our genetic analyses revealed a function of dynamin in propelling invas...

    Ruihui Zhang, Donghoon M. Lee, John R. Jimah, Nathalie Gerassimov… in Nature Cell Biology (2020)

  4. No Access

    Article

    Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

    Proliferating cells, compared with quiescent cells, are more dependent on glucose for their growth. Although glucose transport in keratinocytes is mediated largely by the Glut1 facilitative transporter, we found ...

    Zhuzhen Zhang, Zhenzhen Zi, Eunice E. Lee, Jiawei Zhao… in Nature Medicine (2018)

  5. No Access

    Article

    Lipid switches and traffic control

    Transport vesicles that bud from one cell membrane must change identity before fusing with another. During the process of clathrin-mediated endocytosis, various lipid phosphates mediate this identity change. See ...

    Sandra L. Schmid, Marcel Mettlen in Nature (2013)

  6. No Access

    Article

    An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

    A genome-wide RNA interference analysis identifies the septin family of cytoskeletal filaments as important regulators of store-operated Ca2+ entry into the cell; septins are shown to organize plasma membrane mic...

    Sonia Sharma, Ariel Quintana, Gregory M. Findlay, Marcel Mettlen, Beate Baust… in Nature (2013)

  7. No Access

    Article

    Robust single-particle tracking in live-cell time-lapse sequences

    Single-particle tracking methods allow detailed analysis of protein movement in cells, but existing tracking algorithms have substantial limitations, particularly at high particle densities. A new software too...

    Khuloud Jaqaman, Dinah Loerke, Marcel Mettlen, Hirotaka Kuwata… in Nature Methods (2008)