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  1. Article

    Open Access

    Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation

    Severe COVID-19 is characterized by an increase in the number and changes in the function of innate immune cells including neutrophils. However, it is not known how the metabolome of immune cells changes in pa...

    Yafeng Li, Jessica S. Hook, Qing Ding, Xue **ao, Stephen S. Chung… in Nature Communications (2023)

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  2. Article

    Neutrophil Extracellular Trap Formation Potential Correlates with Lung Disease Severity in COVID-19 Patients

    Severe lung inflammation is common in life-threatening coronavirus disease 2019 (COVID-19). This study tested the hypothesis that polymorphonuclear (PMN, neutrophil) phenotype early in the course of disease pr...

    Nedha Kinnare, Jessica S Hook, Parth A Patel, Nancy L Monson… in Inflammation (2022)

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  3. Article

    Alveolar Macrophage Chemokine Secretion Mediates Neutrophilic Lung Injury in Nox2-Deficient Mice

    Acute lung injury (ALI), develo** as a component of the systemic inflammatory response syndrome (SIRS), leads to significant morbidity and mortality. Reactive oxygen species (ROS), produced in part by the ne...

    Renee M. Potera, Mou Cao, Lin F. Jordan, Richard T. Hogg, Jessica S. Hook… in Inflammation (2019)

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