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  1. Article

    Open Access

    Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury

    Chronic kidney diseases and acute kidney injury are mechanistically distinct kidney diseases. While chronic kidney diseases are associated with podocyte injury, acute kidney injury affects renal tubular epithe...

    Kamalika Mukherjee, Changkyu Gu, Agnieszka Collins, Marcel Mettlen… in Nature Communications (2022)

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  2. Article

    Open Access

    Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis

    ErbB2 signalling, which is amplified by EphA2 binding, is an important therapeutic target for breast cancer. Despite the importance of the EphA2/ErbB2 complex in promoting breast tumorigenesis, the mechanism b...

    Haeryung Lee, Hyuna Noh, Jiyoung Mun, Changkyu Gu, Sanja Sever… in Nature Communications (2016)

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  3. No Access

    Article

    Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models

    The small molecule Bis-T-23 targets actin polymerization to improve renal morphology and function in several mouse models of kidney injury and disease.

    Mario Schiffer, Beina Teng, Changkyu Gu, Valentina A Shchedrina… in Nature Medicine (2015)

  4. No Access

    Article

    The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells

    Recent studies in our laboratory demonstrate that ligand-mediated activation of the EphA8 receptor critically regulates cell adhesion and migration. In this report, we show that the EphA8 receptor induces neur...

    Changkyu Gu, Sungbo Shim, Jongdae Shin, Jieun Kim, Jonghoon Park, Kyuhyung Han… in Oncogene (2005)