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Article
A comparative analysis of the distribution of glyprolines after their administration by different ways
The distribution of the glyprolines, Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc), was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uni...
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Article
The use of tritium-labeled dermorphin for studying the interactions of C-terminal dermorphin fragment Tyr-Pro-Ser-NH2 and its stereoisomer Tyr-D-Pro-Ser-NH2 with opioid receptors
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Article
Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system
Peptide anxiolytic selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) applied intraperitoneally in doses of 0.01, 0.1, 1.0, and 10.0 mg/kg to mice reduces behavioral manifestations of dopaminergic system induced by apomorph...
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Article
Evenly tritium labeled peptides in study of peptide in vivo and in vitro biodegradation
Biologically active peptides evenly labeled with tritium were used for studying the in vitro and in vivo biodegradation of the peptides. Tritium-labeled peptides with a specific radioactivity of 50–150 Ci/mmol...
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Article
Reactions between β-Casomorphins-7 and 5-HT2-Serotonin Receptors
Radioreceptor analysis showed that human β-casomorphin-7 displaced 3H-spiperone from 5-HT2-serotonin receptors of the rat cerebral frontal cortex: EC50 8±1 μM. Human and bovine β-casomorphin-7 dose-dependently bl...
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Article
A Synthesis of Tritium-Labeled Olanzapine
A synthesis of olanzapine, 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine, was carried out and the conditions for its tritium labeling were optimized to obtain a tritium-labeled olanzapi...
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Article
Leu-Enkephalin Generally Labeled with Tritium in Studying the Selank Inhibiting Effect on the Enkephalin-Degrading Enzymes of Human Blood Plasma
A method of analysis of enkephalinase activity in blood plasma based on the application of Leu-enkephalin generally labeled with tritium at all its amino acid residues was developed. The method allows the simu...
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Article
Half-Life of Leu-Enkephalin in the Serum of Infants of the First Year of Life on Different Types of Feeding: Relationship with Temperament
The half-life of leu-enkephalin in the serum of infants aged under 1 year is significantly shorter than in adults. In girls leu-enkephalin half-life is significantly longer than in boys. The half-life of leu-e...
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Article
Effects of Selank on Behavioral Reactions and Activities of Plasma Enkephalin-Degrading Enzymes in Mice with Different Phenotypes of Emotional and Stress Reactions
Comparative study of plasma activities of enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions revealed significant differences between intact BALB/c and C57Bl/6 mic...
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Article
Semax and Selank Inhibit the Enkephalin-Degrading Enzymes of Human Serum
Dose-dependent effect of synthetic heptapeptides Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the enkephalin-degrading enzymes of human serum was demonstrated. The inhibitory...
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Article
The Inhibitory Effect of Selank on Enkephalin-Degrading Enzymes as a Possible Mechanism of Its Anxiolytic Activity
Examination of patients with various forms of anxiety and phobic disorders (according to DSM-4 criteria) demonstrated a considerable shortening of enkephalin half-life and reduced total enkephalinase activity ...
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Article
Anxiolytic effect of dalargin on rat behavior in Vogel's conflict test and in elevated plus-maze
The anxiolytic effects of the δ-opioid receptor agonist dalargin revealed in two behavioral tests in outbred albino rats were blocked by naloxone. The effect of dalargin depended on the initial locomotor activ...
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Article
Relationship of adaptive capabilities in athletes to the type of reaction of their opioid system to stressful physical exercise
Eleven highly skilled skiers are examined during and after prolonged exercising on a bicycle ergometer at a Vo2 equal to 80% of the maximum. Parameters of mechanical work, Vo2, plasma lactate concentration, and a...
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Article
Transcranial electrostimulation augments physical working capacity
Transcranial stimulation using weak electric current with rigidly fixed parameters is shown to prolong the time during which BALB/c and CBA/Lac mice are capable of swimming with a weight attached to their body...
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Article
Normalizing effect of dalargin on blood glucocorticoid and opioid levels in CBA and C57BL/6 mice under footshock stress conditions
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Article
Effect of dalargin of stress-induced change in macrophagal 5′-nucleotidase activity and endogenous cortisol level in mouse blood
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Article
Opioid detection in pupal extract of the Chinese oak silkwormAntheraea pernyi guerin
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Article
Characteristics of some parameters of the immune status, and opioid and interferon systems of athletes
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Article
Stability and bistability of stationary states in four-wave interaction in a photorefractive medium
The stability of stationary states is investigated analytically and numerically for various four-wave mixing schemes in a photorefractive medium with nonlocal nonlinear response when recorded with a translucen...
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Article
Stimulated scattering in intersecting light beams
