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Chapter and Conference Paper
Establishment of Specific Antibody Producing Human Lines by Antigen Preselection and EBV-Transformation
Human lymphocytes can be immortalized (“transformed”) by laboratory (B95-8) isolates of Epstein Barr virus (EBV) (1). Following primary infection, the virus induces EBNA, the EBV-determined nuclear antigen, in...
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Article
In vitro production of human monoclonal antibodies by Epstein Barr Virus (EBV) cell lines: Practical applications of a monoclonal rheumatoid factor
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Article
Monoclonal antibodies from human cell lines
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Article
Beta-adrenergic-stimulated adenylate cyclase activity in normal and EBV-transformed lymphocytes
Beta-adrenergic-associated cyclic AMP accumulation was studied in intact lymphocytes before and after transformation with Epstein-Barr virus into immortal cell lines. Although a marked reduction in isoproteren...
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Chapter
Human Monoclonal Antibodies Produced by Epstein-Barr Virus Immortalized Cell Lines: Technical and Theoretical Principles
Continuous cell lines that produce monoclonal antibodies are now routinely established from mouse and rat origin according to the hybridoma method (Köhler and Milstein, 1975). This method is still, to a large ...
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Article
Induction of an immune network cascade in cancer patients treated with monoclonal antibodies (ab1)
The antitumor effector functions of unconjugated monoclonal antibodies (mAb) in cancer therapy are not fully understood. Direct cytotoxic mechanisms such as antibody-dependent cellular cytotoxicity, complement...
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Chapter
Human immunodeficiency virus type 1 Vif-derived peptides inhibit the viral protease and arrest virus production