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Article
Frailty, cognitive impairment and mortality among the oldest old
Both frailty and cognitive impairment are increasingly prevalent with advancing age. Nonetheless among the oldest old their relationship is poorly described This study examines the association between frailty ...
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Article
Nutrition and quality of life in the aged
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Article
Simultaneous Measurement of the Photoplethysmographic Signal Variability in the Right and Left Hands
The photoplethysmographic (PPG) signal, which is a measure of the systolic oscillations in the tissue blood volume, spontaneously fluctuates in the respiration rate and in lower frequencies similar to the hear...
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Article
Effect of age on the pharmacokinetics of dipyrone
The pharmacokinetics of the dipyrone metabolite, 4-metylaminoantipyrine (MAA) was evaluated, following the administration of a single oral dose of dipyrone 1.0 g to 12 young (21–30 years) and 9 elderly (73–90 ...
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Article
Hormone and forskolin-stimulated cyclic AMP accumulation in human lymphocytes: reliability of longitudinal time measurements
Reliability of measurement of lymphocyte cyclic AMP synthesis in intact cells was estimated by taking 3 successive blood samples during a one-month period from 11 healthy volunteers. Isoproterenol and prostagl...
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Chapter
Hormone-Stimulated Adenylate Cyclase Activity In Man: Studies With Peripheral Models
Cyclic AMP, the so-called “second messenger” mediates the effects of a number of hormones including catecholamines on a plethora of cell processes (1). The hormone-stimulated adenylate cyclase complex consists...
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Article
Beta-adrenergic-stimulated adenylate cyclase activity in normal and EBV-transformed lymphocytes
Beta-adrenergic-associated cyclic AMP accumulation was studied in intact lymphocytes before and after transformation with Epstein-Barr virus into immortal cell lines. Although a marked reduction in isoproteren...
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Article
The effect of glucagon on plasma cyclic AMP levels in young and elderly subjects
Glucagon-induced rise in plasma cyclic AMP levels was used to study glucagon-sensitive adenylate cyclase activity in aged man. No significant difference was observed in plasma cyclic AMP rise after glucagon (0...