17 Result(s)

Article

Membrane-stabilizing and protective effects of curcumin in a rotenone-induced rat model of Parkinson disease

Parkinson disease (PD) is a chronic progressive neurodegenerative disease characterized by both motor and non-motor features. Numerous risk factors (oxidative stress, free radical formation, and several enviro...

L. V. Darbinyan, K. V. Simonyan, L. E. Hambardzumyan… in Metabolic Brain Disease (2023)

Article

Regulatory Effects of Stevia Rebaudiana on NADPH Oxidase-Related Manifestations of Oxidative Stress in Diabetic Rats with Spinal Cord Injury

For the first time, a method for isolation and purification of Nox isoforms (Nox1+Nox2), as well as of O₂^–-producing stable associates of Nox and lipoprotein-containing NADPH isoforms (NCL associates), from the m...

K. V. Simonyan, V. A. Chavushyan, L. G. Avetisyan, R. M. Simonyan… in Neurophysiology (2021)

Article

NADPH Oxidase and Superoxide-Producing Associates in Cells of the Spinal Cord and Bone Marrow in Diabetic Rats with Spinal Cord Injury

For the first time, a method for isolation and purification of the total fraction of NOX isoforms (NOX1 + NOX2) and the total fraction of O₂ ^– producing stable associates of NOX and NADPH isoformscontaining lipop...

K. V. Simonyan, V. A. Chavushyan, A. G. Lorikyan, R. M. Simonyan… in Neurophysiology (2020)

Article

Ferrihemoglobin induces the release of NADPH oxidase from brain-cell membrane tissue ex vivo: the suppression of this process by galarmin

We developed a simple technique for the isolation of NADPH oxidase (Nox) in a soluble form from the brain-cell membrane (BCM) of rats based on the ability of Nox to form an unstable complex with ferrihemoglobi...

R. M. Simonyan, K. A. Galoyan, G. M. Simonyan, A. R. Hachatryan… in Neurochemical Journal (2013)

Article

The protective role of a hypothalamic proline-rich peptide during acute intoxication of rats by carbon dioxide in combination with oxygen starvation

We measured the contents of NADPH oxidases (Nox) in the membranes of erythrocytes, spleen cells, bone marrow cells, nuclei from spleen cells, and blood serum of rats that were subjected to action of carbon dio...

R. M. Simonyan, L. H. Melconyan, M. A. Babayan, G. M. Simonyan… in Neurochemical Journal (2013)

Article

The regulatory influence of galarmin on the level and activity of rat tissue metalloproteins after doxorubicin-induced nephro- and cardiotoxicity

Doxorubicin (DR) is a potential antineoplastic drug that is used for therapy of different types of malignant tumors (leukemia, lymphoma, mammary tumor, lung, ovarian, pancreatic tumor etc.). However, the long-...

L. H. Tadevosyan, L. N. Arakelyan, M. A. Simonyan, G. A. Kevorkian… in Neurochemical Journal (2011)

Article

Proline Rich Polypeptide (PRP-1) Increases the Superoxide-Producing and Ferrihemoglobin Reducing Activities of Cytochrome B₅₅₈ Isoforms from Human Lymphosarcoma Tissue Cells

The two cytochromes (cyt) b₅₅₈ of acidic nature, one—95–100 kDa and another one, 60–70 kDa were isolated for the first time from the human’s lymphosarcoma tissue cells using gel filtration and ion exchange chroma...

G. M. Simonyan, K. A. Galoian, R. M. Simonyan, M. A. Simonyan… in Neurochemical Research (2011)

Article

An increase in the activity of NADPH-dependent O ₂ ⁻ -producing and ferrihemoglobin-reducing isoforms of cytochrome b ₅₅₈ from membranes, mitochondria, and nuclei of cells of rats subjected to electrical stimulation of the supraoptic and paraventricular hypothalamic nuclei

Electrical stimulation of supraoptic nuclei (SON) and paraventricular nuclei (PVN) of the hypothalamus increases the immunoreactivity of the rat hypothalamus. However, molecular mechanisms of this effect assoc...

L. G. Melkonyan, R. M. Simonyan, G. M. Simonyan, M. A. Babayan… in Neurochemical Journal (2010)

Article

Evaluating cycvalon activity under conditions of chronic endotoxicosis models in rats

Using the results of instrumental and numerical investigations of structure — activity relationships among derivatives and structural analogs of cinnamic acid, we predicted and then experimentally proved the p...

A. V. Simonyan, V. V. Novochadov, M. A. Simonyan… in Pharmaceutical Chemistry Journal (2007)

Article

Synthesis and antiradical and antioxidant activity of cycvalon and its analogs

A new approach to the activation of components of the condensation of aromatic aldehydes with cyclohexanone, functioning as a receptor for the CH-acid component, is demonstrated. The condensation was performed...

M. A. Simonyan, Kh. Dib, A. N. Pashkov, A. V. Simonyan… in Pharmaceutical Chemistry Journal (2007)

Article

The effect of proline-rich polypeptide on reduction of methemoglobin and formation of superoxide by the b558III cytochrome and suprol metalloproteins in vitro

A synthetic analogue of the proline-rich polypeptide (PRP-1) from neurosecretory granules of bovine neurohypophysis (1.5–7 μg/ml) was shown to stimulate reduction of methemoglobin (metHb) and NADPH-dependent f...

G. M. Simonyan, R. M. Simonyan, G. R. Aghamyan, M. A. Simonyan… in Neurochemical Journal (2007)

Article

Phosphorus Oxychloride in Organic Synthesis. Part 3: Synthesis of α-Benzoylaminocinnamic Acids

A new approach to the activation of reactants during the condensation of aromatic aldehydes with N-aroylglycines (acting as CH-acids) is described. The condensation reaction carried out on heating in phosphoru...

A. A. Avanesyan, A. V. Simonyan, M. A. Simonyan in Pharmaceutical Chemistry Journal (2005)

Article

Imbalance between Rat Blood Metalloproteins in the Early Stage of Hypokinesia

Changes in the contents of blood metalloproteins with prooxidant (plasma cytochromes b558 I and b558 II, erythrocyte membrane cytochromes b558 III and b558 IV, superoxide-producing plasma lipoprotein suprol, a...

V. P. Akopyan, M. A. Simonyan… in Bulletin of Experimental Biology and Medic… (2001)

Article

Quantitative changes in Cu, Zn-activated superoxide dismutase and catalase in the liver of rats with alloxan diabetes

M. A. Simonyan, D. M. Gevorkyan… in Bulletin of Experimental Biology and Medic… (1987)