SpringerLink
Log in

Evaluating cycvalon activity under conditions of chronic endotoxicosis models in rats

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Abstract

Using the results of instrumental and numerical investigations of structure — activity relationships among derivatives and structural analogs of cinnamic acid, we predicted and then experimentally proved the protective action of the new bile-expelling drug cycvalon (a cyclohexanone derivative) in rats under the conditions of model endotoxicosis. The drug effectively prevented cytotoxic damage of liver and kidney tissues related to the vascular and fibroplastic mechanisms. At the same time, cycvalon is of low effectiveness with respect to the development of lung tissue damage, chronic pneumonia, and pneumofibrosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Brazil)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. V. V. Novochadov and V. B. Pisarev, Endotoxicosis: Modeling and Organopathology [in Russian], Volgograd (2005).

  2. A. V. Simonyan, Author's Abstract of Doctoral (Ph.D., Pharm. Sci.) Thesis [in Russian], Pyatigorsk (1992).

  3. V. V. Novochadov, in: Current Problems in Morphology (Proceedings of the Siberian Medical University) [in Russian], Tomsk (2000), pp. 105–106.

  4. D. S. Sarkisov and Yu. L. Perov, A Guide to Histological Techniques [in Russian], Meditsina, Moscow (1996).

    Google Scholar 

  5. G. G. Avtandilov, Principles of Quantitative Pathological Anatomy [in Russian], Meditsina, Moscow (2002).

    Google Scholar 

  6. V. V. Novochadov, Author's Abstract of Doctoral (Ph.D., Med. Sci.) Thesis [in Russian), Volgograd (2001).

  7. V. M. Zaitsev, V. T. Liflyandskii, and V. I. Marinkin, Applied Statistics for Medicine [in Russian], St. Petersburg (2003).

Download references

Author information

Authors and Affiliations

  1. Volgograd State Medical University, Volgograd, Russia

    A. V. Simonyan, V. V. Novochadov, M. A. Simonyan & A. N. Goryachev

Authors
  1. A. V. Simonyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. V. Novochadov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. A. Simonyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. N. Goryachev
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 9, pp. 9–11, September, 2007.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Simonyan, A.V., Novochadov, V.V., Simonyan, M.A. et al. Evaluating cycvalon activity under conditions of chronic endotoxicosis models in rats. Pharm Chem J 41, 461–463 (2007). https://doi.org/10.1007/s11094-007-0100-8

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-007-0100-8

Keywords

Search

Navigation