-
Article
Open AccessCAnceR IN PreGnancy (CARING) – a retrospective study of cancer diagnosed during pregnancy in the United Kingdom
The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population.
-
Article
The complex circumstellar environment of supernova 2023ixf
The early evolution of a supernova (SN) can reveal information about the environment and the progenitor star. When a star explodes in vacuum, the first photons to escape from its surface appear as a brief, hou...
-
Article
Open AccessRelevance of a subjective quality of life questionnaire for long-term homeless persons with schizophrenia
Increasing numbers of programs are addressing the specific needs of homeless people with schizophrenia in terms of access to housing, healthcare, basic human rights and other domains. Although quality of life ...
-
Article
The H3K27me3 demethylase, KDM6B, is induced by Epstein–Barr virus and over-expressed in Hodgkin's Lymphoma
There is now evidence for both increased and decreased activity of the enzymes controlling the methylation of lysine 27 on histone 3 (H3K27) in cancer. One of these enzymes, KDM6B formally known as JMJD3, a hi...
-
Article
Experimental entanglement of four particles
Quantum mechanics allows for many-particle wavefunctions that cannot be factorized into a product of single-particle wavefunctions, even when the constituent particles are entirely distinct. Such ‘entangled’ s...
-
Article
Photorefractive amplification and generation of light beams in BaTiO3 controlled by the intensity of the pump light
by photorefractive forward four-wave mixing. The intensity of a signal beam is amplified by a factor up to 3000. We show that heating of the crystal by absorption of the pump light influences the gain because...
-
Article
Epstein-Barr virus latent membrane protein-1 (LMP1) C-terminus activation region 2 (CTAR2) maps to the far C-terminus and requires oligomerisation for NF-κB activation
The Epstein-Barr virus Latent Membrane Protein-1 (LMP1) has structural features and functions consistent with it being a constitutively active cell surface receptor. The known association of LMP1 with members ...
-
Article
The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer
HLA-restricted cytotoxic T-lymphocyte (CTL) recognition of human papillomavirus (HPV) oncogene products may be important in the control of the HPV infections associated with the development of cervical cancer....
-
Chapter
Advances in the Understanding of EBV Associated Lymphoproliferative Disorders
Neoplasia may be defined as the uncontrolled growth of a specific population of cells which, in the absence of therapeutic intervention, will eventuate in the death of the patient. Progressive accumulation of...
-
Article
Mn-In-Co, Mn-Pt and Mn-In-Pt Based Contacts to p-GaAs
Mn-In-Co, Mn-In-Pt and Mn-Pt metallizations are used to form ohmic contact on Be-implanted rapid thermally annealed GaAs. The rapid thermal alloying of contact metallizations are performed in A.G. Associates H...
-
Chapter
Analysis of Epstein-Barr Virus Gene Expression in Lymphomas Derived from Normal Human B Cells Grafted into SCID Mice
The recent demonstration that C.B-17scid/scid mice (hereafter referred to as SCID mice) could be grafted successfully with human haematopoietic cells (Hosier et al., 1988; McCune et al., 1988; Kamel-Reid and Dick...
-
Article
The application of immunoassays and fluorometry to the detection of polycyclic hydrocarbon-macromolecular adducts and anti-adduct antibodies in humans
The metabolic activation of polycyclic aromatic hydrocarbons (PAH) to chemical species that form covalent adducts with cellular macromolecules (DNA and protein) is central to theories of carcinogenesis. Assays...
-
Chapter
Distribution of Epstein-Barr Virus Strains with Different EBNA 2 Genotypes in Burkitt-Endemic Areas
The Epstein-Barr (EB) virus shows a striking association with two human tumours, Burkitt’s lymphoma (BL) and nasopharyngeal carcinoma (NPC), both of which exhibit an unusual geographical distribution. This is ...
-
Chapter
Cellular Controls over EBV Infection
Several facets of the biology of Epstein-Barr virus (EBV)make this agent particularly interesting to immunolo-gists. Firstly, the virus selectively infects human B lymphocytes and can act as a polyclonal B cel...
-
Article
Burkitt-like lymphoma in an English child: Characterisation of tumour biopsy cells and of the derived tumour cell line
An eight year old English boy presented with an abdominal undifferentiated 'Burkitt-like' lymphoma. Lymphoma cells from ascitic fluid were cultured on a human embryo fibroblast feeder layer and, after a short ...
-
Article
Epstein–Barr virus-positive Burkitt's lymphoma cells not recognized by virus-specific T-cell surveillance
The pathogenesis of Epstein–Barr (EB) virus-positive Burkitt's lymphoma (BL) appears to involve the combined actions of (1) virus-induced B-cell proliferation, and (2) a rare chromosomal translocation juxtapos...
-
Chapter and Conference Paper
Endemic and Sporadic Cases of Epstein-Barr Virus-Positive Burkitt’s Lymphoma: Immunological Characterization of Derived Cell Lines
Burkitt’s lymphoma (BL) is a tumour which is endemic in regions of Africa and New Guinea where temperature and rainfall are high and malaria is holoendemic. BL also occurs worldwide (sporadic BL), but at a muc...
-
Article
Epstein–Barr virus-specific cytotoxic T-cell clones restricted through a single HLA antigen
HLA-restriction of antiviral cytotoxic T-cell responses in man, precisely analogous to the H–2-restriction first documented in murine virus infections1–3, has now been unequivocally demonstrated with influenza vi...
