30 Result(s)

Article

Correction to: Incidence of tuberous sclerosis and age at first diagnosis: new data and emerging trends from a national, prospective surveillance study

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Daniel Ebrahimi-Fakhari, Lilian Lisa Mann… in Orphanet Journal of Rare Diseases (2019)

Article

Incidence of tuberous sclerosis and age at first diagnosis: new data and emerging trends from a national, prospective surveillance study

Tuberous Sclerosis Complex (TSC) is a rare multisystem disorder. In 2012 diagnostic criteria for TSC were revised. However, data on the incidence of TSC are limited.

Daniel Ebrahimi-Fakhari, Lilian Lisa Mann… in Orphanet Journal of Rare Diseases (2018)

Article

Gene expression profiling at birth characterizing the preterm infant with early onset infection

Early onset infection (EOI) in preterm infants <32 weeks gestational age (GA) is associated with a high mortality rate and the development of severe acute and long-term complications. The pathophysiology of EO...

Anne Hilgendorff, Anita Windhorst, Manuel Klein… in Journal of Molecular Medicine (2017)

Article

Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome

MECP2 (methyl CpG binding protein 2) duplication causes syndromic intellectual disability. Patients often suffer from life-threatening infections, suggesting an additional immunodeficiency. We de...

Michael Bauer, Uwe Kölsch, Renate Krüger… in Journal of Clinical Immunology (2015)

Article

Simulation-based neonatal resuscitation training of medical students: is Peyton’s 4-stage approach more effective than traditional 2-stage technique?

Erol Tutdibi, Ludwig Gortner, Thomas Volk, Erik Reus in Molecular and Cellular Pediatrics (2014)

Article

Mitochondrial mutation m.1555A>G as a risk factor for failed newborn hearing screening in a large cohort of preterm infants

The mitochondrial m.1555A>G mutation is associated with a high rate of permanent hearing loss, if aminoglycosides are given. Preterm infants have an increased risk of permanent hearing loss and are frequently ...

Wolfgang Göpel, Sandra Berkowski, Michael Preuss, Andreas Ziegler… in BMC Pediatrics (2014)

Article

Subgaleal Hematoma

Sascha Meyer, Ludwig Gortner, Hashim Abdul-Khaliq… in The Indian Journal of Pediatrics (2014)

Article

Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages

Investigations on pulmonary macrophages (MΦ) mostly focus on alveolar MΦ (AM) as a well-defined cell population. Characteristics of MΦ in the interstitium, referred to as lung interstitial MΦ (IM), are rather ...

Jessica Hoppstädter, Britta Diesel, Robert Zarbock, Tanja Breinig… in Respiratory Research (2010)

Article

Surfactant replacement and open lung concept – Comparison of two treatment strategies in an experimental model of neonatal ARDS

Several concepts of treatment in neonatal ARDS have been proposed in the last years. The present study compared the effects of open lung concept positive pressure ventilation (PPV_OLC) with a conventional ventilat...

Anne Hilgendorff, Ece Aslan, Thomas Schaible, Ludwig Gortner… in BMC Pulmonary Medicine (2008)

Article

Arginine-vasopressin in catecholamine-refractory septic versus non-septic shock in extremely low birth weight infants with acute renal injury

The aim of this study was to assess the efficacy of arginine-vasopressin (AVP) as a rescue therapy in catecholamine-refractory septic and non-septic shock in extremely low birth weight (ELBW) infants with acut...

Sascha Meyer, Sven Gottschling, Ali Baghai, Donald Wurm, Ludwig Gortner in Critical Care (2006)

Article

Synthetic and natural surfactant differentially modulate inflammation after meconium aspiration

Anne Hilgendorff, Daniel Rawer, Martin Doerner, Erol Tutdibi… in Intensive Care Medicine (2005)

Article

Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced

The collectin surfactant protein-D (SP-D) plays a significant role in innate immunity. Epidemiological studies described associations between single nucleotide polymorphisms (SNPs) of the human gene coding sur...

Kathrin Heidinger, Inke R. König, Anette Bohnert, Anja Kleinsteiber… in Immunogenetics (2005)

Article

Assessing Cortisol Production in Preterm Infants: Do Not Dispose of the Nappies

The aim of this study was to develop a practical approach allowing a reliable and noninvasive assessment of cortisol production rates in premature infants. To measure daily urinary excretion rates of glucocort...

Matthias Heckmann, Michaela F Hartmann, Birgit Kampschulte… in Pediatric Research (2005)

Article

Synthetic and natural surfactant differentially modulate inflammation after meconium aspiration

Meconium aspiration syndrome remains a relevant cause of neonatal respiratory failure and is associated with severe pulmonary changes including surfactant inactivation and pronounced inflammatory changes. The ...

Anne Hilgendorff, Daniel Rawer, Martin Doerner, Erol Tutdibi… in Intensive Care Medicine (2003)

Article

Increased risk of bronchopulmonary dysplasia and increased mortality in very preterm infants being small for gestational age

The objective was to evaluate the impact of being born small for gestational age (SGA) on neonatal mortality and neonatal pulmonary morbidity in preterm infants <32 weeks of gestation.

Irwin Reiss, Eva Landmann, Matthias Heckmann… in Archives of Gynecology and Obstetrics (2003)

Article

Early decompressive craniectomy and duraplasty for refractory intracranial hypertension in children: results of a pilot study

Severe traumatic brain injury (TBI) in childhood is associated with a high mortality and morbidity. Decompressive craniectomy has regained therapeutic interest during past years; however, treatment guidelines ...

Bettina Ruf, Matthias Heckmann, Ilona Schroth, Monika Hügens-Penzel… in Critical Care (2003)

Article

Treatment with bovine surfactant in severe acute respiratory distress syndrome in children: a randomized multicenter study

To determine whether bovine surfactant given in cases of severe pediatric acute respiratory distress syndrome (ARDS) improves oxygenation.

Jens Christian Möller, Thomas Schaible, Claudia Roll… in Intensive Care Medicine (2003)

Article

Saline lavage with substitution of bovine surfactant in term neonates with meconium aspiration syndrome (MAS) transferred for extracorporeal membrane oxygenation (ECMO): a pilot study

Meconium aspiration syndrome (MAS) is still a condition associatedwith a high mortality, and many patients require extracorporeal membraneoxygenation (ECMO) as rescue therapy. Beneficial effects of surfactant ...

Jens C Möller, Martina Kohl, Irwin Reiss, Wiebke Diederich… in Critical Care (1999)

Article

Effects of Elastase and Glucocorticoids on Gas Exchange in the Rat Lung Lavage Model 1655

Ludwig Gortner, Ernst Weller, Martina Kohl, Wiebke Maroske in Pediatric Research (1998)

Article

Modified Bovine Surfactant Preparations in the Rat Lung Lavage Model

Ludwig Gortner, Eberhard Weller, Wiebke Maroske, Martina Kohl in Pediatric Research (1997)