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Article
Open AccessAnti-CCL2 therapy reduces oxygen toxicity to the immature lung
Oxygen toxicity constitutes a key contributor to bronchopulmonary dysplasia (BPD). Critical step in the pathogenesis of BPD is the inflammatory response in the immature lung with the release of pro-inflammator...
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Article
Open AccessDelineating morbidity patterns in preterm infants at near-term age using a data-driven approach
Long-term survival after premature birth is significantly determined by development of morbidities, primarily affecting the cardio-respiratory or central nervous system. Existing studies are limited to pairwis...
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Article
Open AccessValidation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia
To demonstrate and validate the improvement of current risk stratification for bronchopulmonary dysplasia (BPD) early after birth by plasma protein markers (sialic acid-binding Ig-like lectin 14 (SIGLEC-14), b...
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Article
Open AccessAssociation of immune cell recruitment and BPD development
In the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into the development of injury and ultimately chronic disease, also known as bronchopulmonary dysplasia (BPD). The focu...
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Article
Open AccessTRAIL protects the immature lung from hyperoxic injury
The hyperoxia-induced pro-inflammatory response and tissue damage constitute pivotal steps leading to bronchopulmonary dysplasia (BPD) in the immature lung. The pro-inflammatory cytokines are considered attrac...
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Article
Open AccessSingle-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenoty**’
The in vivo phenotypic profile of T cells reactive to severe acute respiratory syndrome (SARS)-CoV-2 antigens remains poorly understood. Conventional methods to detect antigen-reactive T cells require in vitro...
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Article
Open AccessAlveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptiona...
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Article
Open AccessDifferential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive injury and reprogramming of the lung epithelium are thought to be critical drivers of disease progression, contributing to f...
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Article
Open AccessGas exchange mechanisms in preterm infants on HFOV – a computational approach
High-frequency oscillatory ventilation (HFOV) is a commonly used therapy applied to neonates requiring ventilatory support during their first weeks of life. Despite its wide application, the underlying gas exc...
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Article
Open AccessThe BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease
The development of neonatal chronic lung disease (nCLD), i.e., bronchopulmonary dysplasia (BPD) in preterm infants, significantly determines long-term outcome in this patient population. Risk factors include m...
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Article
Open AccessGene expression profiling at birth characterizing the preterm infant with early onset infection
Early onset infection (EOI) in preterm infants <32 weeks gestational age (GA) is associated with a high mortality rate and the development of severe acute and long-term complications. The pathophysiology of EO...
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Article
Open AccessLinking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling
Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due...
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Article
Open AccessEarly injury of the neonatal lung contributes to premature lung aging: a hypothesis
Chronic lung disease of the newborn, also known as bronchopulmonary dysplasia (BPD), is the most common chronic lung disease in early infancy and results in an increased risk for long-lasting pulmonary impairm...
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Article
Open AccessVisualization of neonatal lung injury associated with mechanical ventilation using x-ray dark-field radiography
Mechanical ventilation (MV) and supplementation of oxygen-enriched gas, often needed in postnatal resuscitation procedures, are known to be main risk factors for impaired pulmonary development in the preterm a...
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Article
Open AccessBronchopulmonary dysplasia - an overview about pathophysiologic concepts
Neonatal chronic lung disease in the preterm infant, i.e. bronchopulmonary dysplasia (BPD) is characterized by impaired pulmonary development with its effects persisting into adulthood. Triggered in the immatu...
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Article
Open AccessSurfactant replacement and open lung concept – Comparison of two treatment strategies in an experimental model of neonatal ARDS
Several concepts of treatment in neonatal ARDS have been proposed in the last years. The present study compared the effects of open lung concept positive pressure ventilation (PPVOLC) with a conventional ventilat...
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Article
Synthetic and natural surfactant differentially modulate inflammation after meconium aspiration
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Article
Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced
The collectin surfactant protein-D (SP-D) plays a significant role in innate immunity. Epidemiological studies described associations between single nucleotide polymorphisms (SNPs) of the human gene coding sur...
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Article
Synthetic and natural surfactant differentially modulate inflammation after meconium aspiration
Meconium aspiration syndrome remains a relevant cause of neonatal respiratory failure and is associated with severe pulmonary changes including surfactant inactivation and pronounced inflammatory changes. The ...
