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Article
Open AccessA randomised controlled trial in preterm infants comparing prophylactic with selective “less invasive surfactant administration” (pro.LISA)
Respiratory distress syndrome is the main cause of mortality and morbidity in preterm infants. “Less invasive surfactant administration” (LISA), which describes intratracheal surfactant administration to spont...
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Article
Präventionskonzepte in der Frühgeborenenmedizin
Präventionskonzepte in der Frühgeborenenmedizin setzen bereits im perinatalen Kontext an, um bestmögliche Ausgangsbedingungen zu schaffen. Die umfangreichste Studienlage für präventive Interventionen ergibt si...
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Article
Open AccessSepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms
In 2013 German infection surveillance guidelines recommended weekly colonization screening for multidrug-resistant (MDRO) or highly epidemic organisms for neonatal intensive care units (NICUs) and extended hyg...
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Article
Open AccessTwo-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study
Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechan...
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Article
Open AccessPreterm birth and sustained inflammation: consequences for the neonate
Almost half of all preterm births are caused or triggered by an inflammatory process at the feto-maternal interface resulting in preterm labor or rupture of membranes with or without chorioamnionitis (“first i...
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Article
Open AccessThe circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders
During pregnancy, maternal endocrine signals drive fetal development and program the offspring’s physiology. A disruption of maternal glucocorticoid (GC) homeostasis increases the child’s risk of develo** ps...
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Article
Open AccessSurgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age
Gastrointestinal complications during the neonatal period, i.e. necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP), are associated with adverse short-term outcome in very-low-birthwei...
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Article
Open AccessReversible dilative cardiomyopathy after electrical injury: a case report
Dilative cardiomyopathy is an uncommon cardiac complication of electric shock.
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Article
Treatment and outcome data of very low birth weight infants treated with less invasive surfactant administration in comparison to intubation and mechanical ventilation in the clinical setting of a cross-sectional observational multicenter study
The aim of this study was to contribute further to existing randomized controlled trials and meta-analyses showing advantages in the outcome of less invasive surfactant administration (LISA)-treated infants an...
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Article
Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants
The aim of this study was to explore the role of the lectin pathway in neonatal sepsis through the study of MBL and MASP2 levels and their relationship with infection in a cohort of very-low-birth-weight infan...
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Article
Open AccessLess invasive surfactant administration and complications of preterm birth
In a large cohort study of the German Neonatal Network (GNN) we aimed to evaluate whether less invasive surfactant administration (LISA) strategy is associated with complications of preterm birth. Within the o...
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Article
Volume, size, professionals' specialization and nutrition management of NICUs and their association with treatment quality in VLBW infants
To assess the association of volume, size, the availability of highly-specialized professionals and nutrition management of NICUs with treatment quality among VLBW infants.
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Article
Necrotizing enterocolitis and high intestinal iron uptake due to genetic variants
Intestinal iron is a nutritional compound, which is essential for enteric microbiota. We evaluated the hypothesis that polymorphisms, which are known modifiers of intestinal iron uptake in adults, are associat...
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Article
Open AccessLactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics
We performed an observational study with very-low-birth weight infants (VLBWI) ≤33 weeks of gestation born in centers of the German Neonatal Network (GNN; (total n = 8534, n = 6229 received probiotics). The pr...
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Article
About the power of biostatistics in sibling analysis—comparison of empirical and simulated data
The determination of potential sibship is a common task in routine kinship analysis, but often the putative parents are not available for analysis anymore. Then, a sibling analysis has to be conducted investig...
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Article
FUT 2 polymorphism and outcome in very-low-birth-weight infants
To determine whether the secretor gene fucosyltransferase (FUT)2 polymorphism G428A is predictive for adverse outcomes in a large cohort of very-low-birth weight (VLBW) infants.
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Open AccessGenetic risk factors for respiratory diseases of preterm infants
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Open AccessMitochondrial mutation m.1555A>G as a risk factor for failed newborn hearing screening in a large cohort of preterm infants
The mitochondrial m.1555A>G mutation is associated with a high rate of permanent hearing loss, if aminoglycosides are given. Preterm infants have an increased risk of permanent hearing loss and are frequently ...
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Article
Intrapartum colonization with Streptococcus pneumoniae, early-onset sepsis and deficient specific neonatal immune responses
Intrapartum colonization with Streptococcus pneumoniae (S. pneumoniae) is a rare but important risk factor for severe courses of early-onset sepsis (EOS) in the newborn, as underlined in the case of a preterm inf...
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Article
Mutations of Genes Involved in the Innate Immune System as Predictors of Sepsis in Very Low Birth Weight Infants
Mutations of genes involved in the innate immune system have been reported to be associated with an increased sepsis rate in adults. We determined the −159T mutation of the CD14 gene, the 896G mutation of the ...
