23 Result(s)
within
Loïc Le Marchand
Public Health
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Article
Exposure of nonsmoking women to environmental tobacco smoke: a 10-country collaborative study
The interpretation and interpretability of epidemiologic studies of environmental tobacco smoke (ETS) depend largely on the validity of self-reported exposure. To investigate to what extent questionnaires can ...
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Dietary patterns of female nonsmokers with and without exposure to environmental tobacco smoke
The relationship of passive smoking to diet was examined in 82 female nonsmokers who provided a quantitative diet history in 1986. Exposure to environmental tobacco smoke (ETS) was assessed by urinary cotinine...
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Article
Obesity in youth and middle age and risk of colorectal cancer in men
To investigate an association between colon cancer and obesity during early adulthood—a potentially important period in the etiology of this disease—the authors assembled, by computer linkage, a population-bas...
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A case-control study of diet and colorectal cancer in a multiethnic population in Hawaii (United States): lipids and foods of animal origin
Temporal trend and migrant studies have indicated that the etiologyof colorectal cancer is predominantly environmental and, hence, modifiable.Animal fat intake has been frequently, but inconsistently, associat...
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B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
Objective: This population-based case–control study was designed to investigate the interrelationships between polymorphisms in the methylenetetrahydrofolate (MTHFR C677T and A1298C) gene and other genes (MTR A2...
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Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States)
Objective: Cytochrome P450 1A1 plays a major role in the bioactivation of a number of tobacco procarcinogens. Much interest has focused on a polymorphism in exon 7 of the CYP1A1 gene which has been associated wi...
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Article
NAT2, meat consumption and colorectal cancer incidence: an ecological study among 27 countries
The polymorphic gene NAT2 is a major determinant of N-acetyltransferase activity and, thus, may be responsible for differences in one’s ability to bioactivate heterocyclic amines, a class of procarcinogens in coo...
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Circulating fatty acids and prostate cancer risk in a nested case–control study: the Multiethnic Cohort
Dietary fat, including specific fatty acids, has been proposed to contribute to prostate cancer pathogenesis, but findings from the studies based on biomarkers have been conflicting.
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Article
Association of maternal and intrauterine characteristics with age at menarche in a multiethnic population in Hawaii
This study seeks to further elucidate the mother–daughter hormonal relationship and its effects on daughter’s breast cancer risk through the association with early age at menarche. Four hundred and thirty-eigh...
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Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population
Chronic inflammation, which is suspected to play a role in the development of colorectal cancer (CRC), has rarely been studied in colorectal adenoma. We investigated the inter-relationships of serum levels of ...
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Article
Association of plasma vitamin B6 with risk of colorectal adenoma in a multiethnic case–control study
Circulating level of vitamin B6 has been inversely associated with colorectal cancer (CRC) risk but, unlike for folate, few studies have examined the relationship of vitamin B6 to colorectal adenoma, the precu...
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Article
Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels with risk of malignant melanoma
We examined the relationship of insulin-like growth factor-I (IGF-I) and its primary growth factor, IGF binding protein-3 (IGFBP-3) with malignant melanoma using interview data and sera from cases (n = 286) and c...
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Article
Erythrocyte membrane fatty acid composition, serum lipids, and non-Hodgkin’s lymphoma risk in a nested case–control study: the multiethnic cohort
Composition of dietary fatty acid intake, which influences cytokine production, may contribute to the development of non-Hodgkin’s lymphoma (NHL). Serum lipid levels may serve as biomarkers of inflammation ass...
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Article
Racial/ethnic differences in lifestyle-related factors and prostate cancer risk: the Multiethnic Cohort Study
Older age, African ancestry, and family history of prostate cancer are well-established risk factors for prostate cancer, and all are non-modifiable. Various lifestyle factors have been examined in relation to...
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Article
Reliability of plasma lipopolysaccharide-binding protein (LBP) from repeated measures in healthy adults
Plasma lipopolysaccharide-binding protein (LBP), a measure of internal exposure to bacterial lipopolysaccharide, has been associated with several chronic conditions and may be a marker of chronic inflammation;...
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Characterizing the neighborhood obesogenic environment in the Multiethnic Cohort: a multi-level infrastructure for cancer health disparities research
We characterized the neighborhood obesogenic environment in the Multiethnic Cohort (MEC) by examining the associations of obesity with attributes of the social and built environment, establishing a multi-level...
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Article
Self-reported dietary flavonoid intake and serum markers of inflammation: the multiethnic cohort
To examine if dietary intake of foods rich in flavonoids, which have been shown to be inversely associated with chronic diseases, is associated with inflammatory processes.
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Intake of cocoa products and risk of type-2 diabetes: the multiethnic cohort
As cocoa products may be protective against chronic disease due to their polyphenol content, the current study determined the association of chocolate consumption and flavanol intake with type-2 diabetes (T2D)...
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Article
Association of serum γ-tocopherol levels with mortality: the Multiethnic Cohort Study
γ-Tocopherol has unique properties that protect against nitrogen oxide-mediated cellular damage. To elucidate the potential role of γ-tocopherol in the aging process, we examined the associations of serum γ-to...
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Differences in the association of diet quality with body fat distribution between men and women
As dietary intake and endocrine metabolism are vastly different by sex, we evaluated differences in the association of diet quality with body composition between men and women.
