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Article
Open AccessNoncanonical function of folate through folate receptor 1 during neural tube formation
Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The mechanisms underlying NTDs and their prevention by...
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Article
Presence of circulating folic acid in plasma and its relation with dietary intake, vitamin B complex concentrations and genetic variants
The aim of this study was to investigate circulating folic acid (FA) and predict circulating FA concentrations in the population related to dietary intake, vitamin concentrations, and interaction with the gene...
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Article
Plasma B-vitamins and one-carbon metabolites and the risk of breast cancer in younger women
We examined the association of plasma B-vitamins and metabolites, and related genetic variants, with risk of breast cancer among predominantly premenopausal women.
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Article
Open AccessProspective study of serum B vitamins levels and oesophageal and gastric cancers in China
B vitamins play an essential role in DNA synthesis and methylation, and may protect against oesophageal and gastric cancers. In this case-cohort study, subjects were enrolled from the General Population Nutrit...
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Article
Open AccessArsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh
Arsenic induces neural tube defects in several animal models, but its potential to cause neural tube defects in humans is unknown. Our objective was to investigate the associations between maternal arsenic exp...
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Article
High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort
Shortening of telomeres, the protective structures at the ends of eukaryotic chromosomes, is associated with age-related pathologies. Telomere length is influenced by DNA integrity and DNA and histone methyla...
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Article
Open AccessThe association between vitamin B12, albuminuria and reduced kidney function: an observational cohort study
Variants in CUBN, the gene encoding cubilin, a proximal tubular transport protein, have been associated with albuminuria and vitamin B12 (B12) deficiency. We hypothesized that low levels of B12 would be associate...
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Article
Prediagnostic plasma vitamin B6 (pyridoxal 5′-phosphate) and survival in patients with colorectal cancer
Higher plasma pyridoxal 5′-phosphate (PLP) levels are associated with a decreased incidence of colorectal cancer, but the influence of plasma PLP on survival of patients with colorectal cancer is unknown. We p...
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Article
Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case–control studies
Few prospective studies have examined the associations between blood levels of folate, in conjunction with methylenetetrahydrofolate reductase (MTHFR) polymorphisms, and colorectal cancer. We evaluated the ass...
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Article
Association of plasma vitamin B6 with risk of colorectal adenoma in a multiethnic case–control study
Circulating level of vitamin B6 has been inversely associated with colorectal cancer (CRC) risk but, unlike for folate, few studies have examined the relationship of vitamin B6 to colorectal adenoma, the precu...
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Article
A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma
Previous studies have found associations between one-carbon metabolism factors and risk of several cancers, but little is known regarding renal cell carcinoma (RCC). We conducted a nested case–control study wi...
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Article
Erratum to: Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet
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Article
Common variants of FUT2 are associated with plasma vitamin B12 levels
David Hunter and colleagues report the discovery of associations between variants in FUT2 and plasma vitamin B12 levels. FUT2 encodes α,1,2-fucosyltransferase and is the classic human secretor locus that determin...
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Correspondence
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Article
Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet
Experimentally restricting dietary calories, while maintaining adequate dietary nutrient content, extends lifespan in phylogenetically diverse species; thus suggesting the existence of conserved pathways which...
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Article
Open AccessPyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis
Patients with rheumatoid arthritis have subnormal vitamin B6 status, both quantitatively and functionally. Abnormal vitamin B6 status in rheumatoid arthritis has been associated with spontaneous tumor necrosis...
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Article
Open AccessInflammation causes tissue-specific depletion of vitamin B6
Previously we observed strong and consistent associations between vitamin B6 status and several indicators of inflammation in patients with rheumatoid arthritis. Clinical indicators, including the disability scor...
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Article
Elevated Serum Homocysteine levels and Increased risk of Invasive Cervical Cancer in US Women
Objectives: To explore the relationship between serum homocysteine, a sensitive biomarker for folate inadequacy and problems in one-carbon metabolism, and invasive cervical cancer. Methods: A large case–control ...
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Blood Homocysteine Levels in the National Health and Nutrition Examination Survey (Nhanes III) in the United States: Preliminary Findings by Age and Sex
Evidence from scores of observational studies from many parts of the world have demonstrated an association between elevated blood total homocysteine levels and the risk of cardiovascular disease, peripheral v...
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Chapter
Association Between Plasma Homocysteine, Vitamin Status, and Extracranial Carotid-Artery Stenosis in the Framingham Study Population
Recent epidemiologic studies suggest that elevated homocysteine concentrations in plasma represent a risk factor for vascular disease and stroke. In the present study, we analyzed plasma samples from the 20th ...
