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Article
Open AccessEffect of omega-3 fatty acid diet on prostate cancer progression and cholesterol efflux in tumor-associated macrophages—dependence on GPR120
Preclinical and clinical translational research supports the role of an ω-3 fatty acid diet for prostate cancer prevention and treatment. The anti-prostate cancer effects of an ω-3 diet require a functional ho...
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Article
Effects of dietary omega-3 fatty acids on orthotopic prostate cancer progression, tumor associated macrophages, angiogenesis and T-cell activation—dependence on GPR120
The antiprostate cancer effects of dietary ω-3 fatty acids (FAs) were previously found to be dependent on host G-protein coupled receptor 120 (GPR120). Using an orthotopic tumor model and an ex-vivo model of b...
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Article
Effect of dietary omega-3 fatty acids on castrate-resistant prostate cancer and tumor-associated macrophages
M2-like macrophages are associated with the pathogenesis of castrate-resistant prostate cancer (CRPC). We sought to determine if dietary omega-3 fatty acids (ω-3 FAs) delay the development and progression of C...
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Article
Open AccessArctigenin inhibits prostate tumor growth in high-fat diet fed mice through dual actions on adipose tissue and tumor
This study investigated the inhibitory effect of arctigenin, a novel anti-inflammatory lignan, on prostate cancer in obese conditions both in vitro and in vivo. In vitro obese models were established by co-cultur...
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Article
Open AccessPomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial
In vitro and animal studies have demonstrated that topical application and oral consumption of pomegranate reduces UVB-induced skin damage. We therefore investigated if oral pomegranate consumption will reduce ph...
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Article
Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice
Decaffeinated green tea (GT) and black tea (BT) polyphenols inhibit weight gain in mice fed an obesogenic diet. Since the intestinal microflora is an important contributor to obesity, it was the objective of t...
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Article
Reply to the letter by Demark-Wahnefried et al.
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Article
Phase II prospective randomized trial of weight loss prior to radical prostatectomy
Obesity is associated with poorly differentiated and advanced prostate cancer and increased mortality. In preclinical models, caloric restriction delays prostate cancer progression and prolongs survival. We so...
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Article
Open AccessHealth benefit of vegetable/fruit juice-based diet: Role of microbiome
The gut microbiota is an important contributor to human health. Vegetable/fruit juices provide polyphenols, oligosaccharides, fiber and nitrate (beet juice), which may induce a prebiotic-like effect. Juice-bas...
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Article
Open AccessAmbient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites
Ambient particulate matter (PM) exposure is associated with atherosclerosis and inflammatory bowel disease. Ultrafine particles (UFP, dp < 0.1–0.2 μm) are redox active components of PM. We hypothesized that orall...
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Article
Open AccessGreen tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
Chemotherapy with docetaxel (Doc) remains the standard treatment for metastatic and castration-resistance prostate cancer (CRPC). However, the clinical success of Doc is limited by its chemoresistance and side...
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Article
Open AccessWeight loss reduces breast ductal fluid estrogens in obese postmenopausal women: a single arm intervention pilot study
Accumulation of excess body fat increases breast cancer risk after menopause. Whether the localized breast is differently influenced by adipose tissue compared to the rest of the body, has not been well studie...
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Article
Erythrocyte membrane fatty acid composition, serum lipids, and non-Hodgkin’s lymphoma risk in a nested case–control study: the multiethnic cohort
Composition of dietary fatty acid intake, which influences cytokine production, may contribute to the development of non-Hodgkin’s lymphoma (NHL). Serum lipid levels may serve as biomarkers of inflammation ass...
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Article
Open AccessVariation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case–control study
Folate-associated one-carbon metabolism (FOCM) is an important pathway in colorectal neoplasia risk but data on genetic variation in this pathway are largely limited to studies of single SNPs in selected genes.
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Article
Open AccessArginine and antioxidant supplement on performance in elderly male cyclists: a randomized controlled trial
Human exercise capacity declines with advancing age. These changes often result in loss of physical fitness and more rapid senescence. Nitric oxide (NO) has been implicated in improvement of exercise capacity ...
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Article
Circulating fatty acids and prostate cancer risk in a nested case–control study: the Multiethnic Cohort
Dietary fat, including specific fatty acids, has been proposed to contribute to prostate cancer pathogenesis, but findings from the studies based on biomarkers have been conflicting.
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The Role of Folate, Choline, and Methionine in Carcinogenesis Induced by Methyl-Deficient Diets
In humans, deficiencies of choline and methionine are not likely to occur except for an occasional methyl deficiency as evidenced by low plasma choline levels and development of fatty livers in some patients g...
