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Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels with risk of malignant melanoma

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Abstract

We examined the relationship of insulin-like growth factor-I (IGF-I) and its primary growth factor, IGF binding protein-3 (IGFBP-3) with malignant melanoma using interview data and sera from cases (n = 286) and controls (n = 289) in a population-based case–control study conducted in 1986–1992 on Oahu, Hawaii. Serum IGF-I and IGFBP-3 concentrations were measured by ELISA. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression and adjusting for age, sex, education, number of blistering sunburns, ability to tan, hair color, energy intake, BMI, height, smoking status, and drinking status. An inverse relationship was found between IGF-I concentration and melanoma (OR for upper vs. lower tertile: 0.44, 95% CI: 0.25–0.79), but clear associations were not observed between malignant melanoma and upper tertiles of IGFBP-3 and the IGF-1/IGFBP-3 molar ratio. The inverse association with IGF-I was strongest among subjects who did not report a history of non-melanoma skin cancer (NMSC) (OR for ≥ vs. < median: 0.39, 95% CI: 0.24–0.65), and a positive association was found among those with such a history (OR: 3.6, 95% CI: 1.0–13; p interaction = 0.0035). Our findings observed here between serum IGF-I and malignant melanoma warrants replication in studies with a larger sample size and a prospective design.

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Abbreviations

IGF-I:

Insulin-like growth factor-I

IGFBP-3:

Insulin-like growth factor binding protein-3

ELISA:

Enzyme-linked immunosorbent assay

OR:

Odds ratio

CI:

Confidence interval

NMSC:

Non-melanoma skin cancer

BMI:

Body mass index

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Acknowledgments

This work was supported by NCI grant P01 CA33619 and US department of Heath and Human Services contract N01-PC67010. S.L.P and the lab assays were supported by NCI T32 CA09142. We would like to thank Dr. Gang Zeng and his research group at UCLA for use of their laboratory space and equipment. In addition, we are in debt to the study participants for contributing their time and specimens.

Conflict of interest

The authors state no conflict of interest.

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Authors and Affiliations

  1. Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, Honolulu, HI, 96813, USA

    Sungshim Lani Park, Lynne R. Wilkens, Laurence N. Kolonel & Loïc Le Marchand

  2. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Veronica Wendy Setiawan

  3. Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Peter A. Kanetsky

  4. Department of Epidemiology, School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA

    Zuo-Feng Zhang

  5. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA

    Zuo-Feng Zhang

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  1. Sungshim Lani Park
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Correspondence to Sungshim Lani Park.

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Park, S.L., Setiawan, V.W., Kanetsky, P.A. et al. Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels with risk of malignant melanoma. Cancer Causes Control 22, 1267–1275 (2011). https://doi.org/10.1007/s10552-011-9800-1

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