5 Result(s)
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Article
Author Correction: Origin and evolution of the octoploid strawberry genome
In the version of this article originally published, author Joshua R. Puzey was incorrectly listed as having affiliation 7 (School of Plant Sciences, University of Arizona, Tucson, AZ, USA); affiliation 6 (Dep...
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Article
Open AccessOrigin and evolution of the octoploid strawberry genome
Cultivated strawberry emerged from the hybridization of two wild octoploid species, both descendants from the merger of four diploid progenitor species into a single nucleus more than 1 million years ago. Here...
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Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
In this study, the authors compare the RNA binding patterns of FUS/TLS and TDP-43. Although these proteins regulate the processing of mostly distinct gene products, they do show concurrent regulation of a subs...
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The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain
The Rbfox family of RNA binding proteins mediate alternative splicing. Douglas Black and colleagues show that targeted deletion of the mouse Rbfox1 gene in the CNS alters splice isoforms of a subset of genes and ...
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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
The authors identify brain RNA targets for TDP-43, a RNA binding protein linked to ALS. RNAs derived from genes with very long introns were more affected by TDP-43 levels. TDP-43 also auto-regulated its own sy...
