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  1. Article

    Open Access

    Therapeutic potential of berberine in attenuating cholestatic liver injury: insights from a PSC mouse model

    Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by progressive biliary inflammation and bile duct injury. Berberine (BBR) is a bioactive isoquinoline alkaloid found in various her...

    Yanyan Wang, Derrick Zhao, Lianyong Su, Yun-Ling Tai, Grayson W. Way in Cell & Bioscience (2024)

  2. Article

    Open Access

    Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice

    Alcohol use disorder is a major cause of morbidity, which requires newer treatment approaches. We previously showed in a randomized clinical trial that alcohol craving and consumption reduces after fecal trans...

    Jennifer T. Wolstenholme, Justin M. Saunders, Maren Smith in Nature Communications (2022)

  3. Article

    Open Access

    RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression

    NAFLD has become the most common chronic liver disease worldwide. Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key player in regulat...

    Yanyan Wang, Yun-Ling Tai, Grayson Way, **g Zeng, Derrick Zhao in Cell & Bioscience (2022)