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Article
Open AccessA systematic evaluation of the biocompatibility of cucurbit[7]uril in mice
As one of the most water-soluble members in the macrocyclic cucurbit[n]uril (CB[n]) family, CB[7] has attracted increasing attention in pharmaceutical and biomedical fields. Despite extensive studies regarding th...
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Article
DNA origami-templated assembly of plasmonic nanostructures with enhanced Raman scattering
DNA origami have been established as versatile templates to fabricate plasmonic nanostructures in predefined shapes and multiple dimensions. Limited to the size of DNA origami, which are approximate to 100 nm,...
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Article
A new synthetic ligand that activates QscR and blocks antibiotic-tolerant biofilm formation in Pseudomonas aeruginosa
Quorum sensing (QS) has been recognized to play an important role in many pathogenic bacteria and has become a novel target for the treatment of infectious disease. Pseudomonas aeruginosa is highly resistant to a...
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Article
A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa
Quorum sensing (QS) has been a novel target for the treatment of infectious diseases. Here structural analogs of Pseudomonas aeruginosa autoinducer N-acyl homoserine lactone (AHL) were investigated for QS inhibit...
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Article
Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase
Bacterial cells sense their population density through a sophisticated cell–cell communication system and trigger expression of particular genes when the density reaches a threshold. This type of gene regulati...
