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Article
Open AccessDifferentially expressed microRNAs in peripheral blood cell are associated with downregulated expression of IgE in nonallergic childhood asthma
Childhood asthma is a heterogeneous disease characterized by chronic airway inflammation, leading to a broad range of clinical presentations. Nonallergic asthma is asthma without allergic sensitization. Both c...
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Article
Open AccessRisk factors for subsequent lupus nephritis in patients with juvenile-onset systemic lupus erythematosus: a retrospective cohort study
Lupus nephritis (LN) is a crucial organ involvement in systemic lupus erythematosus (SLE). Patients with LN have higher morbidity and mortality rates than those without. Among all patients with LN, 20–40% had ...
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Article
Clinical and Immunological Defects and Outcomes in Patients with Chromosome 22q11.2 Deletion Syndrome
Chromosome 22q11.2 deletion syndrome (22q11.2DS) is the most common microdeletion syndrome in humans and can present with highly variable clinical manifestations. Immune deficiencies occur because of thymic hy...
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Article
Predictive characteristics to discriminate the longitudinal outcomes of childhood asthma: a retrospective program-based study
Childhood asthma is an inflammatory disease with heterogeneous outcomes. We sought to determine the impact of total IgE, blood eosinophil, allergen sensitization, and inhaled corticosteroid (ICS) on longitudin...
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Article
Open AccessClinical, laboratory characteristics and growth outcomes of children with growing pains
Growing pains (GP), a common and benign pain syndrome of unknown etiology, is characterized by bilateral recurrent leg pain in childhood. There are no standardized diagnostic criteria for GP, and the diagnosis...
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Article
Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring
Atopic dermatitis (AD) is the leading chronic skin inflammatory disease and the initial manifestation of atopic march. Available evidence supports the notion that primary prevention early in life leads to a de...
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Article
Open AccessDifferential parameters between activity flare and acute infection in pediatric patients with systemic lupus erythematosus
Systemic lupus erythematosus (SLE) patients are vulnerable to infections. We aim to explore the approach to differentiate active infection from disease activity in pediatric SLE patients. Fifty pediatric SLE p...
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Article
Open AccessOnset age is a risk factor for refractory pediatric IgA vasculitis: a retrospective cohort study
Though outcome differences between children and adults with immunoglobulin A vasculitis (IgAV) has been well documented, it remains unclear if disease features in pediatric IgAV patients vary with onset age. W...
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Article
Open AccessClinical manifestations and anti-TNF alpha therapy of juvenile Behçet’s disease in Taiwan
Behçet’s disease (BD) is a rare vasculitic disorder affecting all sizes of vessels. Among BD patients, 4 to 25% of patients with diagnosed age younger than 16 years old are defined as juvenile BD (JBD). This s...
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Article
Clinical characteristics of children with positive anti-SSA/SSB antibodies
This study aimed to characterize the manifestations of clinical symptoms and signs, primary rheumatic diseases, and other autoantibodies in pediatric patients with positive anti-SSA and/or anti-SSB antibodies....
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Article
Acute myocarditis and ventricular fibrillation as initial presentation of pediatric systemic lupus erythematosus
Acute myocarditis and ventricular arrhythmia are rarely seen as the initial presentation of systemic lupus erythematosus (SLE) in children. We reported the case of a 12-year-old girl with congestive heart fail...
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Article
Clinical analysis of macrophage activation syndrome in pediatric patients with autoimmune diseases
Macrophage activation syndrome (MAS) belongs to secondary hemophagocytic lymphohistiocytosis (HLH) syndrome. It is usually associated with rheumatic diseases. We retrospectively reviewed our hospital’s medical...
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Article
Genetics and Immunopathogenesis of IgA Nephropathy
IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. The hallmark of IgAN is underglycosylation in the hinge region of IgA1. Increasing evidence supports the underglycosylated IgA-contain...
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Article
Fifteen-year experience of pediatric-onset mixed connective tissue disease
The aim of this study was to investigate the initial clinical manifestations, laboratory data, complications, and outcomes of patients with pediatric-onset mixed connective tissue disease (MCTD) in Taiwan. We ...
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Article
Open AccessThe effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells
Propolis, an ancient herbal medicine, has been reported the beneficial effect both in asthma patients and murine model of asthma, but the mechanism was not clearly understood. In this study, the effect of caff...
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Article
Leukocytoclastic vasculitis with severe cardiac involvement in an infant: a case report
Severe visceral involvement in leukocytoclastic vasculitis is rare. We report here the case of a 2-month-old male infant with leukocytoclastic vasculitis who initially presented with fever and skin purpura. En...
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Article
Renal manifestations in Henoch–Schönlein purpura: a 10-year clinical study
Henoch–Schönlein purpura (HSP) is an IgA-mediated systemic small vessel vasculitis of childhood. It is characterized by the symptoms including nonthrombocytopenic purpura, abdominal pain, hematuria/proteinuria...
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Article
Retrospective analysis of the renal outcome of pediatric lupus nephritis
The aim of this study was to analyze the renal outcome of pediatric lupus nephritis in the past two decades. We retrospectively reviewed the medical records of patients who fulfilled the 1987 American Rheumati...
