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  1. Article

    Open Access

    CD200R activation on naïve T cells by B cells induces suppressive activity of T cells via IL-24

    CD200 is an anti-inflammatory protein that facilitates signal transduction through its receptor, CD200R, in cells, resulting in immune response suppression. This includes reducing M1-like macrophages, enhancin...

    Kuan-Hua Chu, Bor-Luen Chiang in Cellular and Molecular Life Sciences (2024)

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    Article

    A B-1a cell subset induces Foxp3− T cells with regulatory activity through an IL-10-independent pathway

    Regulatory T (Treg) cells play a critical role in the maintenance of tolerance. B-1a cells belong to a specific and functionally important B-cell subset that exerts its regulatory role through the production o...

    Ling-Hui Hsu, Kun-Po Li, Kuan-Hua Chu, Bor-Luen Chiang in Cellular & Molecular Immunology (2015)

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    Article

    Genetics and Immunopathogenesis of IgA Nephropathy

    IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. The hallmark of IgAN is underglycosylation in the hinge region of IgA1. Increasing evidence supports the underglycosylated IgA-contain...

    Hsin-Hui Yu, Kuan-Hua Chu, Yao-Hsu Yang… in Clinical Reviews in Allergy & Immunology (2011)

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    Article

    Arsenic trioxide alleviates airway hyperresponsiveness and eosinophilia in a murine model of asthma

    Asthma is one of the most common chronic airway inflammatory diseases. The clinical hallmarks of asthma include elevated serum levels of immunoglobulin E (IgE), eosinophilic inflammation and airway hyper-respo...

    Kuan-Hua Chu, Chen-Chen Lee, Shao-Chi Hsin… in Cellular & Molecular Immunology (2010)