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Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring

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Abstract

Atopic dermatitis (AD) is the leading chronic skin inflammatory disease and the initial manifestation of atopic march. Available evidence supports the notion that primary prevention early in life leads to a decreased incidence of AD, thus possibly decreasing the subsequent occurrence of atopic march. Nutritional status is essential to a proper functioning immune system and is valued for its important role in AD. Essential nutrients, which include carbohydrates, proteins, lipids, vitamins, and minerals, are transferred from the mother to the fetus through the placenta during gestation. Various nutrients, such as polyunsaturated fatty acids (PUFAs) and vitamin D, were studied in relation to maternal status and offspring allergy. However, no strong evidence indicates that a single nutrient or food in mothers’ diet significantly affects the risk of childhood AD. In the light of current evidence, mothers should not either increase nor avoid consuming these nutrients to prevent or ameliorate allergic diseases in their offspring. Each essential nutrient has an important role in fetal development, and current government recommendations suggest specific intake amounts for pregnant women. This review discusses evidence on how various nutrients, including lipids (monounsaturated fatty acids, PUFAs, saturated fatty acids, and short-chain fatty acids), carbohydrates (oligosaccharides and polysaccharides), proteins, vitamins (A, B, C, D, and E), and trace minerals (magnesium, iron, zinc, copper, selenium, and strontium) in maternal status are associated with the development of AD and their possible mechanisms.

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References

  1. Misery L (2011) Atopic dermatitis: new trends and perspectives. Clin Rev Allergy Immunol 41(3):296–297. https://doi.org/10.1007/s12016-010-8247-6

    Article  PubMed  Google Scholar 

  2. Ong PY, Leung DY (2006) Immune dysregulation in atopic dermatitis. Curr Allergy Asthma Rep 6(5):384–389. https://doi.org/10.1007/s11882-996-0008-5

  3. Ong PY, Leung DY (2016) Bacterial and viral infections in atopic dermatitis: a comprehensive review. Clin Rev Allergy Immunol 51(3):329–337. https://doi.org/10.1007/s12016-016-8548-5

    Article  CAS  PubMed  Google Scholar 

  4. Nutten S (2015) Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab 66(Suppl 1):8–16. https://doi.org/10.1159/000370220

    Article  CAS  PubMed  Google Scholar 

  5. Roduit C, Frei R, Loss G, Buchele G, Weber J, Depner M, Loeliger S, Dalphin ML, Roponen M, Hyvarinen A, Riedler J, Dalphin JC, Pekkanen J, von Mutius E, Braun-Fahrlander C, Lauener R, Protection Against Allergy-Study in Rural Environments study g (2012) Development of atopic dermatitis according to age of onset and association with early-life exposures. J Allergy Clin Immunol 130(1):130–136 e135. https://doi.org/10.1016/j.jaci.2012.02.043

    Article  PubMed  Google Scholar 

  6. Han H, Roan F, Ziegler SF (2017) The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines. Immunol Rev 278(1):116–130. https://doi.org/10.1111/imr.12546

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Simpson EL, Berry TM, Brown PA, Hanifin JM (2010) A pilot study of emollient therapy for the primary prevention of atopic dermatitis. J Am Acad Dermatol 63(4):587–593. https://doi.org/10.1016/j.jaad.2009.11.011

    Article  PubMed  PubMed Central  Google Scholar 

  8. Sausenthaler S, Koletzko S, Schaaf B, Lehmann I, Borte M, Herbarth O, von Berg A, Wichmann HE, Heinrich J, Group LS (2007) Maternal diet during pregnancy in relation to eczema and allergic sensitization in the offspring at 2 y of age. Am J Clin Nutr 85(2):530–537. https://doi.org/10.1093/ajcn/85.2.530

    Article  CAS  PubMed  Google Scholar 

  9. Miles EA, Calder PC (2015) Maternal diet and its influence on the development of allergic disease. Clin Exp Allergy 45(1):63–74. https://doi.org/10.1111/cea.12453

    Article  CAS  PubMed  Google Scholar 

  10. Bedard A, Northstone K, Holloway JW, Henderson AJ, Shaheen SO (2018) Maternal dietary antioxidant intake in pregnancy and childhood respiratory and atopic outcomes: birth cohort study. Eur Respir J 52(2). https://doi.org/10.1183/13993003.00507-2018

  11. Wu G, Bazer FW, Cudd TA, Meininger CJ, Spencer TE (2004) Maternal nutrition and fetal development. J Nutr 134(9):2169–2172. https://doi.org/10.1093/jn/134.9.2169

    Article  CAS  PubMed  Google Scholar 

  12. Chatzi L, Torrent M, Romieu I, Garcia-Esteban R, Ferrer C, Vioque J, Kogevinas M, Sunyer J (2008) Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood. Thorax 63(6):507–513. https://doi.org/10.1136/thx.2007.081745

    Article  CAS  PubMed  Google Scholar 

  13. Netting MJ, Middleton PF, Makrides M (2014) Does maternal diet during pregnancy and lactation affect outcomes in offspring? A systematic review of food-based approaches. Nutrition (Burbank, Los Angeles County, Calif) 30(11–12):1225–1241. https://doi.org/10.1016/j.nut.2014.02.015

    Article  CAS  Google Scholar 

  14. Romieu I, Torrent M, Garcia-Esteban R, Ferrer C, Ribas-Fito N, Anto JM, Sunyer J (2007) Maternal fish intake during pregnancy and atopy and asthma in infancy. Clin Exp Allergy 37(4):518–525. https://doi.org/10.1111/j.1365-2222.2007.02685.x

    Article  CAS  PubMed  Google Scholar 

  15. Miyake Y, Sasaki S, Tanaka K, Hirota Y (2010) Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants. Eur Respir J 35(6):1228–1234. https://doi.org/10.1183/09031936.00100609

    Article  CAS  PubMed  Google Scholar 

  16. Miyake Y, Sasaki S, Tanaka K, Hirota Y (2010) Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants. Allergy 65(6):758–765. https://doi.org/10.1111/j.1398-9995.2009.02267.x

    Article  CAS  PubMed  Google Scholar 

  17. Willers SM, Devereux G, Craig LCA, McNeill G, Wijga AH, Abou El-Magd W, Turner SW, Helms PJ, Seaton A (2007) Maternal food consumption during pregnancy and asthma, respiratory and atopic symptoms in 5-year-old children. Thorax 62(9):773–779. https://doi.org/10.1136/thx.2006.074187

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Miyake Y, Okubo H, Sasaki S, Tanaka K, Hirota Y (2011) Maternal dietary patterns during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study. Pediatr Allergy Immunol 22(7):734–741. https://doi.org/10.1111/j.1399-3038.2011.01176.x

    Article  PubMed  Google Scholar 

  19. Miyake Y, Yura A, Iki M (2003) Breastfeeding and the prevalence of symptoms of allergic disorders in Japanese adolescents. Clin Exp Allergy 33(3):312–316. https://doi.org/10.1046/j.1365-2222.2003.t01-1-01607.x

  20. Hollis BW, Wagner CL, Howard CR, Ebeling M, Shary JR, Smith PG, Taylor SN, Morella K, Lawrence RA, Hulsey TC (2015) Maternal versus infant vitamin D supplementation during lactation: a randomized controlled trial. Pediatrics 136(4):625–634. https://doi.org/10.1542/peds.2015-1669

    Article  PubMed  PubMed Central  Google Scholar 

  21. Kim JH (2017) Role of breast-feeding in the development of atopic dermatitis in early childhood. Allergy, Asthma Immunol Res 9(4):285–287. https://doi.org/10.4168/aair.2017.9.4.285

    Article  Google Scholar 

  22. Lien TY, Goldman RD (2011) Breastfeeding and maternal diet in atopic dermatitis. Can Fam Physician 57(12):1403–1405

    PubMed  PubMed Central  Google Scholar 

  23. Guardamagna O, Cagliero P (2016) Lipid metabolism in the human fetus development. In: Bhattacharya N, Stubblefield PG (eds) Human fetal growth and development: first and second trimesters. Springer International Publishing, Cham, pp 183–195. https://doi.org/10.1007/978-3-319-14874-8_12

    Chapter  Google Scholar 

  24. Yaqoob P, Calder PC (2007) Fatty acids and immune function: new insights into mechanisms. Br J Nutr 98(Suppl 1):S41–S45. https://doi.org/10.1017/S0007114507832995

    Article  CAS  PubMed  Google Scholar 

  25. Fritsche K (2006) Fatty acids as modulators of the immune response. Annu Rev Nutr 26:45–73. https://doi.org/10.1146/annurev.nutr.25.050304.092610

    Article  CAS  PubMed  Google Scholar 

  26. German JB, Dillard CJ (2004) Saturated fats: what dietary intake? Am J Clin Nutr 80(3):550–559. https://doi.org/10.1093/ajcn/80.3.550

    Article  CAS  PubMed  Google Scholar 

  27. Carta G, Murru E, Banni S, Manca C (2017) Palmitic acid: physiological role, metabolism and nutritional implications. Front Physiol 8:902. https://doi.org/10.3389/fphys.2017.00902

    Article  PubMed  PubMed Central  Google Scholar 

  28. Yu Y, Cai Z, Zheng J, Chen J, Zhang X, Huang XF, Li D (2012) Serum levels of polyunsaturated fatty acids are low in Chinese men with metabolic syndrome, whereas serum levels of saturated fatty acids, zinc, and magnesium are high. Nutr Res (New York, NY) 32(2):71–77. https://doi.org/10.1016/j.nutres.2011.12.004

    Article  CAS  Google Scholar 

  29. Fatima S, Hu X, Gong RH, Huang C, Chen M, Wong HLX, Bian Z, Kwan HY (2019) Palmitic acid is an intracellular signaling molecule involved in disease development. Cell Mol Life Sci. https://doi.org/10.1007/s00018-019-03092-7

  30. Liang Z, Yuan Z, Guo J, Wu J, Yi J, Deng J, Shan Y (2019) Ganoderma lucidum polysaccharides prevent palmitic acid-evoked apoptosis and autophagy in intestinal porcine epithelial cell line via restoration of mitochondrial function and regulation of MAPK and AMPK/Akt/mTOR signaling pathway. Int J Mol Sci 20(3). https://doi.org/10.3390/ijms20030478

  31. Lambertucci RH, Leandro CG, Vinolo MA, Nachbar RT, Dos Reis Silveira L, Hirabara SM, Curi R, Pithon-Curi TC (2012) The effects of palmitic acid on nitric oxide production by rat skeletal muscle: mechanism via superoxide and iNOS activation. Cell Physiol Biochem 30(5):1169–1180. https://doi.org/10.1159/000343307

    Article  CAS  PubMed  Google Scholar 

  32. Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW (2007) Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res 100(11):1589–1596. https://doi.org/10.1161/circresaha.106.142851

    Article  CAS  PubMed  Google Scholar 

  33. Moilanen T, Rasanen L, Viikari J, Akerblom HK, Nikkari T (1992) Correlation of serum fatty acid composition with dietary intake data in children and young adults. Ann Med 24(1):67–70. https://doi.org/10.3109/07853899209164147

    Article  CAS  PubMed  Google Scholar 

  34. Dunder T, Kuikka L, Turtinen J, Rasanen L, Uhari M (2001) Diet, serum fatty acids, and atopic diseases in childhood. Allergy 56(5):425–428. https://doi.org/10.1034/j.1398-9995.2001.056005425.x

    Article  CAS  PubMed  Google Scholar 

  35. Venter C, Meyer RW, Nwaru BI, Roduit C, Untersmayr E, Adel-Patient K, Agache I, Agostoni C, Akdis CA, Bischoff SC, du Toit G, Feeney M, Frei R, Garn H, Greenhawt M, Hoffmann-Sommergruber K, Lunjani N, Maslin K, Mills C, Muraro A, Pali-Scholl I, Poulson LK, Reese I, Renz H, Roberts GC, Smith P, Smolinska S, Sokolowska M, Stanton C, Vlieg-Boerstra B, O'Mahony L (2019) EAACI position paper: influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis. Allergy 74(8):1429–1444. https://doi.org/10.1111/all.13764

    Article  PubMed  Google Scholar 

  36. Woods RK, Raven JM, Walters EH, Abramson MJ, Thien FC (2004) Fatty acid levels and risk of asthma in young adults. Thorax 59(2):105–110. https://doi.org/10.1136/thorax.2003.009498

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Hoppu U, Kalliomaki M, Isolauri E (2000) Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant. Eur J Clin Nutr 54(9):702–705. https://doi.org/10.1038/sj.ejcn.1601079

    Article  CAS  PubMed  Google Scholar 

  38. Saito K, Yokoyama T, Miyake Y, Sasaki S, Tanaka K, Ohya Y, Hirota Y (2010) Maternal meat and fat consumption during pregnancy and suspected atopic eczema in Japanese infants aged 3-4 months: the Osaka Maternal and Child Health Study. Pediatr Allergy Immunol 21(1 Pt 1):38–46. https://doi.org/10.1111/j.1399-3038.2009.00897.x

    Article  PubMed  Google Scholar 

  39. Barman M, Johansson S, Hesselmar B, Wold AE, Sandberg AS, Sandin A (2013) High levels of both n-3 and n-6 long-chain polyunsaturated fatty acids in cord serum phospholipids predict allergy development. PLoS One 8(7):e67920. https://doi.org/10.1371/journal.pone.0067920

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Kamp F, Guo W, Souto R, Pilch PF, Corkey BE, Hamilton JA (2003) Rapid flip-flop of oleic acid across the plasma membrane of adipocytes. J Biol Chem 278(10):7988–7995. https://doi.org/10.1074/jbc.M206648200

    Article  CAS  PubMed  Google Scholar 

  41. Ministry of Health (2006) (revised 2008) Food and nutrition guidelines for healthy pregnant and breastfeeding women: a background paper. Ministry of Health, Wellington. https://www.health.govt.nz/system/files/documents/publications/food-and-nutrition-guidelines-preg-and-bfeed.pdf. Accessed 13 Dec 2019

  42. Nicklas TA, Hampl JS, Taylor CA, Thompson VJ, Heird WC (2004) Monounsaturated fatty acid intake by children and adults: temporal trends and demographic differences. Nutr Rev 62(4):132–141. https://doi.org/10.1111/j.1753-4887.2004.tb00035.x

    Article  PubMed  Google Scholar 

  43. Heinrich J, Hölscher B, Bolte G, Winkler G (2001) Allergic sensitization and diet: ecological analysis in selected European cities. Eur Respir J 17(3):395–402. https://doi.org/10.1183/09031936.01.17303950

  44. Nagel G, Nieters A, Becker N, Linseisen J (2003) The influence of the dietary intake of fatty acids and antioxidants on hay fever in adults. Allergy 58(12):1277–1284. https://doi.org/10.1046/j.1398-9995.2003.00296.x

    Article  CAS  PubMed  Google Scholar 

  45. Khanapure SP, Garvey DS, Janero DR, Letts LG (2007) Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers. Curr Top Med Chem 7(3):311–340. https://doi.org/10.2174/156802607779941314

    Article  CAS  PubMed  Google Scholar 

  46. Miles EA, Calder PC (2017) Can early omega-3 fatty acid exposure reduce risk of childhood allergic disease? Nutrients 9(7). https://doi.org/10.3390/nu9070784

  47. Simopoulos AP (2008) The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 233(6):674–688. https://doi.org/10.3181/0711-MR-311

    Article  CAS  Google Scholar 

  48. Shahidi F, Ambigaipalan P (2018) Omega-3 polyunsaturated fatty acids and their health benefits. Annu Rev Food Sci Technol 9:345–381. https://doi.org/10.1146/annurev-food-111317-095850

  49. Calder PC (2013) n-3 fatty acids, inflammation and immunity: new mechanisms to explain old actions. Proc Nutr Soc 72(3):326–336. https://doi.org/10.1017/S0029665113001031

    Article  CAS  PubMed  Google Scholar 

  50. Dooper MMBW, Wassink L, M'Rabet L, Graus YMF (2002) The modulatory effects of prostaglandin-E on cytokine production by human peripheral blood mononuclear cells are independent of the prostaglandin subtype. Immunology 107(1):152–159. https://doi.org/10.1046/j.1365-2567.2002.01474.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Prescott SL, Calder PC (2004) N-3 polyunsaturated fatty acids and allergic disease. Curr Opin Clin Nutr Metab Care 7(2):123–129. https://doi.org/10.1097/00075197-200403000-00004

  52. Stephensen CB (2004) Fish oil and inflammatory disease: is asthma the next target for n-3 fatty acid supplements? Nutr Rev 62(12):486–489. https://doi.org/10.1111/j.1753-4887.2004.tb00021.x

    Article  PubMed  Google Scholar 

  53. Wong KW (2005) Clinical efficacy of n-3 fatty acid supplementation in patients with asthma. J Am Diet Assoc 105(1):98–105. https://doi.org/10.1016/j.jada.2004.10.009

    Article  CAS  PubMed  Google Scholar 

  54. Plat J, Mensink RP (2005) Food components and immune function. Curr Opin Lipidol 16(1):31–37. https://doi.org/10.1097/00041433-200502000-00007

  55. Simopoulos AP (2006) Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother 60(9):502–507. https://doi.org/10.1016/j.biopha.2006.07.080

    Article  CAS  PubMed  Google Scholar 

  56. Simopoulos AP (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56(8):365–379. https://doi.org/10.1016/s0753-3322(02)00253-6

  57. Oddy WH, de Klerk NH, Kendall GE, Mihrshahi S, Peat JK (2004) Ratio of omega-6 to omega-3 fatty acids and childhood asthma. J Asthma 41(3):319–326. https://doi.org/10.1081/jas-120026089

    Article  CAS  PubMed  Google Scholar 

  58. Simopoulos AP (2002) Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 21(6):495–505. https://doi.org/10.1080/07315724.2002.10719248

    Article  CAS  PubMed  Google Scholar 

  59. Calder PC (2006) n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83(6 Suppl):1505S–1519S. https://doi.org/10.1093/ajcn/83.6.1505S

    Article  CAS  PubMed  Google Scholar 

  60. Yaqoob P, Pala HS, Cortina-Borja M, Newsholme EA, Calder PC (2000) Encapsulated fish oil enriched in alpha-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions. Eur J Clin Investig 30(3):260–274. https://doi.org/10.1046/j.1365-2362.2000.00623.x

    Article  CAS  Google Scholar 

  61. Wada M, DeLong CJ, Hong YH, Rieke CJ, Song I, Sidhu RS, Yuan C, Warnock M, Schmaier AH, Yokoyama C, Smyth EM, Wilson SJ, FitzGerald GA, Garavito RM, Sui de X, Regan JW, Smith WL (2007) Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem 282(31):22254–22266. https://doi.org/10.1074/jbc.M703169200

    Article  CAS  PubMed  Google Scholar 

  62. James MJ, Gibson RA, Cleland LG (2000) Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 71(1 Suppl):343S–348S. https://doi.org/10.1093/ajcn/71.1.343s

    Article  CAS  PubMed  Google Scholar 

  63. Scientific Opinion on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol (2010). EFSA Journal 8 (3). doi:https://doi.org/10.2903/j.efsa.2010.1461

  64. The Scientific Advisory Committee on Nutrition & Committee on Toxicity (2004) Advice on fish consumption: benefits and risks. The Stationary Office, London. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/338801/SACN_Advice_on_Fish_Consumption.pdf. Accessed 13 Dec 2019

  65. Brown TJ, Brainard J, Song F, Wang X, Abdelhamid A, Hooper L, Group P (2019) Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials. BMJ 366:l4697. https://doi.org/10.1136/bmj.l4697

    Article  PubMed  PubMed Central  Google Scholar 

  66. Dunstan JA, Mori TA, Barden A, Beilin LJ, Taylor AL, Holt PG, Prescott SL (2003) Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord blood of infants at high risk of atopy. Clin Exp Allergy 33(4):442–448. https://doi.org/10.1046/j.1365-2222.2003.01590.x

    Article  CAS  PubMed  Google Scholar 

  67. Prescott SL, Barden AE, Mori TA, Dunstan JA (2007) Maternal fish oil supplementation in pregnancy modifies neonatal leukotriene production by cord-blood-derived neutrophils. Clin Sci (Lond) 113(10):409–416. https://doi.org/10.1042/CS20070111

    Article  CAS  Google Scholar 

  68. Prescott SL, Irvine J, Dunstan JA, Hii C, Ferrante A (2007) Protein kinase Czeta: a novel protective neonatal T-cell marker that can be upregulated by allergy prevention strategies. J Allergy Clin Immunol 120(1):200–206. https://doi.org/10.1016/j.jaci.2007.03.045

    Article  CAS  PubMed  Google Scholar 

  69. Dunstan JA, Mori TA, Barden A, Beilin LJ, Taylor AL, Holt PG, Prescott SL (2003) Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol 112(6):1178–1184. https://doi.org/10.1016/j.jaci.2003.09.009

    Article  CAS  PubMed  Google Scholar 

  70. Meldrum SJ, D'Vaz N, Dunstan J, Mori TA, Prescott SL (2011) The Infant Fish Oil Supplementation Study (IFOS): design and research protocol of a double-blind, randomised controlled n--3 LCPUFA intervention trial in term infants. Contemp Clin Trials 32(5):771–778. https://doi.org/10.1016/j.cct.2011.05.019

    Article  CAS  PubMed  Google Scholar 

  71. Krauss-Etschmann S, Hartl D, Rzehak P, Heinrich J, Shadid R, Del Carmen Ramirez-Tortosa M, Campoy C, Pardillo S, Schendel DJ, Decsi T, Demmelmair H, Koletzko BV, Nutraceuticals for Healthier Life Study G (2008) Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. J Allergy Clin Immunol 121(2):464–470 e466. https://doi.org/10.1016/j.jaci.2007.09.018

    Article  CAS  PubMed  Google Scholar 

  72. Noakes PS, Vlachava M, Kremmyda LS, Diaper ND, Miles EA, Erlewyn-Lajeunesse M, Williams AP, Godfrey KM, Calder PC (2012) Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo. Am J Clin Nutr 95(2):395–404. https://doi.org/10.3945/ajcn.111.022954

    Article  CAS  PubMed  Google Scholar 

  73. Miles EA, Noakes PS, Kremmyda LS, Vlachava M, Diaper ND, Rosenlund G, Urwin H, Yaqoob P, Rossary A, Farges MC, Vasson MP, Liaset B, Froyland L, Helmersson J, Basu S, Garcia E, Olza J, Mesa MD, Aguilera CM, Gil A, Robinson SM, Inskip HM, Godfrey KM, Calder PC (2011) The Salmon in Pregnancy Study: study design, subject characteristics, maternal fish and marine n-3 fatty acid intake, and marine n-3 fatty acid status in maternal and umbilical cord blood. Am J Clin Nutr 94(6 Suppl):1986S–1992S. https://doi.org/10.3945/ajcn.110.001636

    Article  CAS  PubMed  Google Scholar 

  74. Furuhjelm C, Warstedt K, Larsson J, Fredriksson M, Bottcher MF, Falth-Magnusson K, Duchen K (2009) Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Paediatr 98(9):1461–1467. https://doi.org/10.1111/j.1651-2227.2009.01355.x

    Article  PubMed  Google Scholar 

  75. Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, Makrides M (2012) Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trial. BMJ (Clin Res ed) 344:e184. https://doi.org/10.1136/bmj.e184

    Article  CAS  Google Scholar 

  76. Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P, Team DOI (2010) Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA 304(15):1675–1683. https://doi.org/10.1001/jama.2010.1507

    Article  CAS  PubMed  Google Scholar 

  77. Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M (2013) Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: the Kyushu Okinawa Maternal and Child Health Study. Ann Epidemiol 23(11):674–680. https://doi.org/10.1016/j.annepidem.2013.08.004

    Article  PubMed  Google Scholar 

  78. Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M (2013) Fish and fat intake and prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study. J Psychiatr Res 47(5):572–578. https://doi.org/10.1016/j.jpsychires.2013.01.012

    Article  PubMed  Google Scholar 

  79. Jedrychowski W, Perera F, Maugeri U, Mrozek-Budzyn D, Miller RL, Flak E, Mroz E, Jacek R, Spengler JD (2011) Effects of prenatal and perinatal exposure to fine air pollutants and maternal fish consumption on the occurrence of infantile eczema. Int Arch Allergy Immunol 155(3):275–281. https://doi.org/10.1159/000320376

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Montes R, Chisaguano AM, Castellote AI, Morales E, Sunyer J, Lopez-Sabater MC (2013) Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. Eur J Clin Nutr 67(6):658–663. https://doi.org/10.1038/ejcn.2013.68

    Article  CAS  PubMed  Google Scholar 

  81. Rucci E, den Dekker HT, de Jongste JC, Steenweg-de-Graaff J, Gaillard R, Pasmans SG, Hofman A, Tiemeier H, Jaddoe VW, Duijts L (2016) Maternal fatty acid levels during pregnancy, childhood lung function and atopic diseases. The Generation R Study. Clin Exp Allergy 46(3):461–471. https://doi.org/10.1111/cea.12613

    Article  CAS  PubMed  Google Scholar 

  82. Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van Iizendoorn MH, de Jongste JC, van der Lugt A, Mackenbach JP, Moll HA, Raat H, Rivadeneira F, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A (2012) The Generation R Study: design and cohort update 2012. Eur J Epidemiol 27(9):739–756. https://doi.org/10.1007/s10654-012-9735-1

    Article  PubMed  Google Scholar 

  83. Gardner KG, Gebretsadik T, Hartman TJ, Rosa MJ, Tylavsky FA, Adgent MA, Moore PE, Kocak M, Bush NR, Davis RL, Lewinn KZ, Wright RJ, Carroll KN (2019) Prenatal omega-3 and omega-6 polyunsaturated fatty acids and childhood atopic dermatitis. J Allergy Clin Immunol Pract. https://doi.org/10.1016/j.jaip.2019.09.031

  84. Nwaru BI, Erkkola M, Lumia M, Kronberg-Kippila C, Ahonen S, Kaila M, Ilonen J, Simell O, Knip M, Veijola R, Virtanen SM (2012) Maternal intake of fatty acids during pregnancy and allergies in the offspring. Br J Nutr 108(4):720–732. https://doi.org/10.1017/S0007114511005940

    Article  CAS  PubMed  Google Scholar 

  85. Kupila A, Muona P, Simell T, Arvilommi P, Savolainen H, Hamalainen AM, Korhonen S, Kimpimaki T, Sjoroos M, Ilonen J, Knip M, Simell O, Juvenile Diabetes Research Foundation Centre for the Prevention of Type IDiF (2001) Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia 44(3):290–297. https://doi.org/10.1007/s001250051616

    Article  CAS  PubMed  Google Scholar 

  86. Newson RB, Shaheen SO, Henderson AJ, Emmett PM, Sherriff A, Calder PC (2004) Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczema. J Allergy Clin Immunol 114(3):531–537. https://doi.org/10.1016/j.jaci.2004.05.010

    Article  CAS  PubMed  Google Scholar 

  87. Golding J, Pembrey M, Jones R, Team AS (2001) ALSPAC--the Avon Longitudinal Study of Parents and Children. I Study Method Paediatr Perinat Epidemiol 15(1):74–87. https://doi.org/10.1046/j.1365-3016.2001.00325.x

    Article  CAS  Google Scholar 

  88. Yu YM, Chan YH, Calder PC, Hardjojo A, Soh SE, Lim AL, Fisk HL, Teoh OH, Goh A, Saw SM, Kwek K, Gluckman PD, Godfrey KM, Chong YS, Shek LP, Pan A, Chong MF, van Bever HP, group Gs (2015) Maternal PUFA status and offspring allergic diseases up to the age of 18 months. Br J Nutr 113(6):975–983. https://doi.org/10.1017/S000711451500001X

    Article  CAS  PubMed  Google Scholar 

  89. Soh SE, Lee SS, Hoon SW, Tan MY, Goh A, Lee BW, Shek LP, Teoh OH, Kwek K, Saw SM, Godfrey K, Chong YS, Gluckman P, van Bever HP (2012) The methodology of the GUSTO cohort study: a novel approach in studying pediatric allergy. Asia Pac Allergy 2(2):144–148. https://doi.org/10.5415/apallergy.2012.2.2.144

    Article  PubMed  PubMed Central  Google Scholar 

  90. Standl M, Demmelmair H, Koletzko B, Heinrich J (2014) Cord blood LC-PUFA composition and allergic diseases during the first 10 yr. results from the LISAplus study. Pediatr Allergy Immunol 25(4):344–350. https://doi.org/10.1111/pai.12212

    Article  PubMed  PubMed Central  Google Scholar 

  91. Heinrich J, Bolte G, Holscher B, Douwes J, Lehmann I, Fahlbusch B, Bischof W, Weiss M, Borte M, Wichmann HE, Group LS (2002) Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates. Eur Respir J 20(3):617–623. https://doi.org/10.1183/09031936.02.02322001

    Article  CAS  PubMed  Google Scholar 

  92. Notenboom ML, Mommers M, Jansen EH, Penders J, Thijs C (2011) Maternal fatty acid status in pregnancy and childhood atopic manifestations: KOALA Birth Cohort Study. Clin Exp Allergy 41(3):407–416. https://doi.org/10.1111/j.1365-2222.2010.03672.x

    Article  CAS  PubMed  Google Scholar 

  93. Kummeling I, Thijs C, Penders J, Snijders BE, Stelma F, Reimerink J, Koopmans M, Dagnelie PC, Huber M, Jansen MC, de Bie R, van den Brandt PA (2005) Etiology of atopy in infancy: the KOALA Birth Cohort Study. Pediatr Allergy Immunol 16(8):679–684. https://doi.org/10.1111/j.1399-3038.2005.00333.x

    Article  PubMed  Google Scholar 

  94. Garlantezec R, Monfort C, Rouget F, Cordier S (2009) Maternal occupational exposure to solvents and congenital malformations: a prospective study in the general population. Occup Environ Med 66(7):456–463. https://doi.org/10.1136/oem.2008.041772

    Article  CAS  PubMed  Google Scholar 

  95. D'Vaz N, Ma Y, Dunstan JA, Lee-Pullen TF, Hii C, Meldrum S, Zhang G, Metcalfe J, Ferrante A, Prescott SL (2012) Neonatal protein kinase C zeta expression determines the neonatal T-cell cytokine phenotype and predicts the development and severity of infant allergic disease. Allergy 67(12):1511–1518. https://doi.org/10.1111/all.12027

    Article  CAS  PubMed  Google Scholar 

  96. Chawes BL, Bonnelykke K, Stokholm J, Vissing NH, Bjarnadottir E, Schoos AM, Wolsk HM, Pedersen TM, Vinding RK, Thorsteinsdottir S, Arianto L, Hallas HW, Heickendorff L, Brix S, Rasmussen MA, Bisgaard H (2016) Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomized clinical trial. JAMA 315(4):353–361. https://doi.org/10.1001/jama.2015.18318

    Article  CAS  PubMed  Google Scholar 

  97. Litonjua AA, Carey VJ, Laranjo N, Harshfield BJ, McElrath TF, O'Connor GT, Sandel M, Iverson RE Jr, Lee-Paritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Hornsby E, Hawrylowicz C, Wu AC, Weiss ST (2016) Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial. JAMA 315(4):362–370. https://doi.org/10.1001/jama.2015.18589

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Goldring ST, Griffiths CJ, Martineau AR, Robinson S, Yu C, Poulton S, Kirkby JC, Stocks J, Hooper R, Shaheen SO, Warner JO, Boyle RJ (2013) Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial. PLoS One 8(6):e66627. https://doi.org/10.1371/journal.pone.0066627

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Norizoe C, Akiyama N, Segawa T, Tachimoto H, Mezawa H, Ida H, Urashima M (2014) Increased food allergy and vitamin D: randomized, double-blind, placebo-controlled trial. Pediatr Int 56(1):6–12. https://doi.org/10.1111/ped.12207

    Article  CAS  PubMed  Google Scholar 

  100. West CE, Dunstan J, McCarthy S, Metcalfe J, D'Vaz N, Meldrum S, Oddy WH, Tulic MK, Prescott SL (2012) Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes. Nutrients 4(11):1747–1758. https://doi.org/10.3390/nu4111747

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Martindale S, McNeill G, Devereux G, Campbell D, Russell G, Seaton A (2005) Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of life. Am J Respir Crit Care Med 171(2):121–128. https://doi.org/10.1164/rccm.200402-220OC

    Article  PubMed  Google Scholar 

  102. Hoppu U, Rinne M, Salo-Vaananen P, Lampi AM, Piironen V, Isolauri E (2005) Vitamin C in breast milk may reduce the risk of atopy in the infant. Eur J Clin Nutr 59(1):123–128. https://doi.org/10.1038/sj.ejcn.1602048

    Article  CAS  PubMed  Google Scholar 

  103. Kiefte-de Jong JC, Timmermans S, Jaddoe VW, Hofman A, Tiemeier H, Steegers EA, de Jongste JC, Moll HA (2012) High circulating folate and vitamin B-12 concentrations in women during pregnancy are associated with increased prevalence of atopic dermatitis in their offspring. J Nutr 142(4):731–738. https://doi.org/10.3945/jn.111.154948

    Article  CAS  PubMed  Google Scholar 

  104. Dunstan JA, West C, McCarthy S, Metcalfe J, Meldrum S, Oddy WH, Tulic MK, D’Vaz N, Prescott SL (2012) The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood. Allergy 67(1):50–57. https://doi.org/10.1111/j.1398-9995.2011.02714.x

    Article  CAS  PubMed  Google Scholar 

  105. Magdelijns FJH, Mommers M, Penders J, Smits L, Thijs C (2011) Folic acid use in pregnancy and the development of atopy, asthma, and lung function in childhood. Pediatrics 128(1):e135–e144. https://doi.org/10.1542/peds.2010-1690

    Article  PubMed  Google Scholar 

  106. Bekkers MBM, Elstgeest LEM, Scholtens S, Haveman-Nies A, de Jongste JC, Kerkhof M, Koppelman GH, Gehring U, Smit HA, Wijga AH (2012) Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy. Eur Respir J 39(6):1468–1474. https://doi.org/10.1183/09031936.00094511

    Article  CAS  PubMed  Google Scholar 

  107. Miyake Y, Sasaki S, Tanaka K, Hirota Y (2011) Maternal B vitamin intake during pregnancy and wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study. Pediatr Allergy Immunol 22(1 Pt 1):69–74. https://doi.org/10.1111/j.1399-3038.2010.01081.x

    Article  PubMed  Google Scholar 

  108. Miyake Y, Tanaka K, Sasaki S, Kiyohara C, Ohya Y, Fukushima W, Yokoyama T, Hirota Y, Osaka M, Child Health Study G (2009) Breastfeeding and atopic eczema in Japanese infants: the Osaka Maternal and Child Health Study. Pediatr Allergy Immunol 20(3):234–241. https://doi.org/10.1111/j.1399-3038.2008.00778.x

    Article  PubMed  Google Scholar 

  109. Kim JH, Jeong KS, Ha EH, Park H, Ha M, Hong YC, Bhang SY, Lee SJ, Lee KY, Lee SH, Kim Y, Kim MH, Chang N (2015) Relationship between prenatal and postnatal exposures to folate and risks of allergic and respiratory diseases in early childhood. Pediatr Pulmonol 50(2):155–163. https://doi.org/10.1002/ppul.23025

    Article  CAS  PubMed  Google Scholar 

  110. Kim BM, Ha M, Park HS, Lee BE, Kim YJ, Hong YC, Kim Y, Chang N, Roh YM, Kim BN, Oh SY, Ha EH, Group MS (2009) The Mothers and Children’s Environmental Health (MOCEH) study. Eur J Epidemiol 24(9):573–583. https://doi.org/10.1007/s10654-009-9370-7

    Article  PubMed  PubMed Central  Google Scholar 

  111. Volgyi E, Carroll KN, Hare ME, Ringwald-Smith K, Piyathilake C, Yoo W, Tylavsky FA (2013) Dietary patterns in pregnancy and effects on nutrient intake in the mid-south: the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) study. Nutrients 5(5):1511–1530. https://doi.org/10.3390/nu5051511

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Roy A, Kocak M, Hartman TJ, Vereen S, Adgent M, Piyathilake C, Tylavsky FA, Carroll KN (2018) Association of prenatal folate status with early childhood wheeze and atopic dermatitis. Pediatr Allergy Immunol 29(2):144–150. https://doi.org/10.1111/pai.12834

    Article  CAS  PubMed  Google Scholar 

  113. van der Valk RJ, Kiefte-de Jong JC, Sonnenschein-van der Voort AM, Duijts L, Hafkamp-de Groen E, Moll HA, Tiemeier H, Steegers EA, Hofman A, Jaddoe VW, de Jongste JC (2013) Neonatal folate, homocysteine, vitamin B12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema. Allergy 68(6):788–795. https://doi.org/10.1111/all.12146

    Article  CAS  PubMed  Google Scholar 

  114. El-Heis S, Crozier SR, Robinson SM, Harvey NC, Cooper C, Inskip HM, Southampton Women's Survey Study G, Godfrey KM (2016) Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months. Clin Exp Allergy 46(10):1337–1343. https://doi.org/10.1111/cea.12782

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  115. Nwaru BI, Ahonen S, Kaila M, Erkkola M, Haapala AM, Kronberg-Kippila C, Veijola R, Ilonen J, Simell O, Knip M, Virtanen SM (2010) Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study. Pediatr Allergy Immunol 21(1 Pt 1):29–37. https://doi.org/10.1111/j.1399-3038.2009.00949.x

    Article  PubMed  Google Scholar 

  116. Baiz N, Dargent-Molina P, Wark JD, Souberbielle JC, Annesi-Maesano I, Group EM-CCS (2014) Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis. J Allergy Clin Immunol 133(1):147–153. https://doi.org/10.1016/j.jaci.2013.05.017

    Article  CAS  PubMed  Google Scholar 

  117. Jones AP, Palmer D, Zhang G, Prescott SL (2012) Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy. Pediatrics 130(5):e1128–e1135. https://doi.org/10.1542/peds.2012-1172

    Article  PubMed  Google Scholar 

  118. Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, Godfrey KM, Cooper C, Princess Anne Hospital Study G (2008) Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62(1):68–77. https://doi.org/10.1038/sj.ejcn.1602680

    Article  CAS  PubMed  Google Scholar 

  119. Wills AK, Shaheen SO, Granell R, Henderson AJ, Fraser WD, Lawlor DA (2013) Maternal 25-hydroxyvitamin D and its association with childhood atopic outcomes and lung function. Clin Exp Allergy 43(10):1180–1188. https://doi.org/10.1111/cea.12172

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  120. Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M (2014) Maternal consumption of dairy products, calcium, and vitamin D during pregnancy and infantile allergic disorders. Ann Allergy Asthma Immunol 113(1):82–87. https://doi.org/10.1016/j.anai.2014.04.023

    Article  CAS  PubMed  Google Scholar 

  121. Chiu CY, Huang SY, Peng YC, Tsai MH, Hua MC, Yao TC, Yeh KW, Huang JL (2015) Maternal vitamin D levels are inversely related to allergic sensitization and atopic diseases in early childhood. Pediatr Allergy Immunol 26(4):337–343. https://doi.org/10.1111/pai.12384

    Article  PubMed  Google Scholar 

  122. Wang LC, Chiang BL, Huang YM, Shen PT, Huang HY, Lin BF (2019) Lower vitamin D levels in the breast milk is associated with atopic dermatitis in early infancy. Pediatr Allergy Immunol. https://doi.org/10.1111/pai.13179

  123. Miyake Y, Sasaki S, Tanaka K, Ohfuji S, Hirota Y (2009) Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study. Thorax 64(9):815–821. https://doi.org/10.1136/thx.2009.115931

    Article  CAS  PubMed  Google Scholar 

  124. Pele F, Bajeux E, Gendron H, Monfort C, Rouget F, Multigner L, Viel JF, Cordier S (2013) Maternal fish and shellfish consumption and wheeze, eczema and food allergy at age two: a prospective cohort study in Brittany, France. Environ Health 12:102. https://doi.org/10.1186/1476-069X-12-102

    Article  PubMed  PubMed Central  Google Scholar 

  125. Jiminez JA, Uwiera TC, Abbott DW, Uwiera RRE, Inglis GD (2017) Butyrate supplementation at high concentrations alters enteric bacterial communities and reduces intestinal inflammation in mice infected with Citrobacter rodentium. mSphere 2(4):e00243–e00217. https://doi.org/10.1128/mSphere.00243-17

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  126. Leonel AJ, Alvarez-Leite JI (2012) Butyrate: implications for intestinal function. Curr Opin Clin Nutr Metab Care 15(5):474–479. https://doi.org/10.1097/MCO.0b013e32835665fa

    Article  CAS  PubMed  Google Scholar 

  127. Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Top** DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H (2013) Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504(7480):446–450. https://doi.org/10.1038/nature12721

    Article  CAS  PubMed  Google Scholar 

  128. Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504(7480):451–455. https://doi.org/10.1038/nature12726

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  129. Fernández J, Redondo-Blanco S, Gutiérrez-del-Río I, Miguélez EM, Villar CJ, Lombó F (2016) Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents: a review. J Funct Foods 25:511–522. https://doi.org/10.1016/j.jff.2016.06.032

    Article  CAS  Google Scholar 

  130. Vinolo MA, Rodrigues HG, Nachbar RT, Curi R (2011) Regulation of inflammation by short chain fatty acids. Nutrients 3(10):858–876. https://doi.org/10.3390/nu3100858

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  131. Böttcher MF, Nordin EK, Sandin A, Midtvedt T, Björkstén B (2000) Microflora-associated characteristics in faeces from allergic and nonallergic infants. Clin Exp Allergy 30(11):1591–1596. https://doi.org/10.1046/j.1365-2222.2000.00982.x

    Article  Google Scholar 

  132. Nylund L, Nermes M, Isolauri E, Salminen S, de Vos WM, Satokari R (2015) Severity of atopic disease inversely correlates with intestinal microbiota diversity and butyrate-producing bacteria. Allergy 70(2):241–244. https://doi.org/10.1111/all.12549

    Article  CAS  PubMed  Google Scholar 

  133. Kim HK, Rutten NB, Besseling-van der Vaart I, Niers LE, Choi YH, Rijkers GT, van Hemert S (2015) Probiotic supplementation influences faecal short chain fatty acids in infants at high risk for eczema. Benefic Microbes 6(6):783–790. https://doi.org/10.3920/BM2015.0056

  134. Mousa A, Naqash A, Lim S (2019) Macronutrient and micronutrient intake during pregnancy: an overview of recent evidence. Nutrients 11(2). https://doi.org/10.3390/nu11020443

  135. Kedia-Mehta N, Finlay DK (2019) Competition for nutrients and its role in controlling immune responses. Nat Commun 10(1):2123. https://doi.org/10.1038/s41467-019-10015-4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  136. Berentzen NE, van Stokkom VL, Gehring U, Koppelman GH, Schaap LA, Smit HA, Wijga AH (2015) Associations of sugar-containing beverages with asthma prevalence in 11-year-old children: the PIAMA birth cohort. Eur J Clin Nutr 69(3):303–308. https://doi.org/10.1038/ejcn.2014.153

    Article  CAS  PubMed  Google Scholar 

  137. Ehlers I, Worm M, Sterry W, Zuberbier T (2001) Sugar is not an aggravating factor in atopic dermatitis. Acta Derm Venereol 81(4):282–284. https://doi.org/10.1080/00015550152572930

    Article  CAS  PubMed  Google Scholar 

  138. Bedard A, Northstone K, Henderson AJ, Shaheen SO (2017) Maternal intake of sugar during pregnancy and childhood respiratory and atopic outcomes. Eur Respir J 50(1). https://doi.org/10.1183/13993003.00073-2017

  139. Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, Berenjian A, Ghasemi Y (2019) Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods 8(3). https://doi.org/10.3390/foods8030092

  140. Brosseau C, Selle A, Palmer DJ, Prescott SL, Barbarot S, Bodinier M (2019) Prebiotics: mechanisms and preventive effects in allergy. Nutrients 11(8). https://doi.org/10.3390/nu11081841

  141. Wu RY, Abdullah M, Määttänen P, Pilar AVC, Scruten E, Johnson-Henry KC, Napper S, O’Brien C, Jones NL, Sherman PM (2017) Protein kinase C δ signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function. Sci Rep 7(1). https://doi.org/10.1038/srep40820

  142. Capitan-Canadas F, Ortega-Gonzalez M, Guadix E, Zarzuelo A, Suarez MD, de Medina FS, Martinez-Augustin O (2014) Prebiotic oligosaccharides directly modulate proinflammatory cytokine production in monocytes via activation of TLR4. Mol Nutr Food Res 58(5):1098–1110. https://doi.org/10.1002/mnfr.201300497

    Article  CAS  PubMed  Google Scholar 

  143. Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT (1987) Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28(10):1221–1227. https://doi.org/10.1136/gut.28.10.1221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  144. Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Top** DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H (2011) Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469(7331):543–547. https://doi.org/10.1038/nature09646

    Article  CAS  PubMed  Google Scholar 

  145. Rusu E, Enache G, Cursaru R, Alexescu A, Radu R, Onila O, Cavallioti T, Rusu F, Posea M, **ga M, Radulian G (2019) Prebiotics and probiotics in atopic dermatitis. Exp Ther Med 18(2):926–931. https://doi.org/10.3892/etm.2019.7678

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  146. Fujiwara R, Takemura N, Watanabe J, Sonoyama K (2010) Maternal consumption of fructo-oligosaccharide diminishes the severity of skin inflammation in offspring of NC/Nga mice. Br J Nutr 103(4):530–538. https://doi.org/10.1017/S000711450999198X

    Article  CAS  PubMed  Google Scholar 

  147. Cuello-Garcia CA, Fiocchi A, Pawankar R, Yepes-Nunez JJ, Morgano GP, Zhang Y, Ahn K, Al-Hammadi S, Agarwal A, Gandhi S, Beyer K, Burks W, Canonica GW, Ebisawa M, Kamenwa R, Lee BW, Li H, Prescott S, Riva JJ, Rosenwasser L, Sampson H, Spigler M, Terracciano L, Vereda A, Waserman S, Schunemann HJ, Brozek JL (2016) World allergy organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): prebiotics. World Allergy Organ J 9:10. https://doi.org/10.1186/s40413-016-0102-7

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  148. Pretorius R, Prescott SL, Palmer DJ (2018) Taking a prebiotic approach to early immunomodulation for allergy prevention. Expert Rev Clin Immunol 14(1):43–51. https://doi.org/10.1080/1744666X.2018.1411191

    Article  CAS  PubMed  Google Scholar 

  149. Cabridain C, Aubert H, Kaeffer B, Badon V, Boivin M, Dochez V, Winer N, Faurel-Paul E, Planche L, Riochet D, Maruani A, Perrotin F, Droitcourt C, Lassel L, Tching-Sin M, Rogers NK, Bodinier M, Barbarot S (2019) Effectiveness of an antenatal maternal supplementation with prebiotics for preventing atopic dermatitis in high-risk children (the PREGRALL study): protocol for a randomised controlled trial. BMJ Open 9(4):e024974. https://doi.org/10.1136/bmjopen-2018-024974

    Article  PubMed  PubMed Central  Google Scholar 

  150. Roberfroid M (1993) Dietary fiber, inulin, and oligofructose: a review comparing their physiological effects. Crit Rev Food Sci Nutr 33(2):103–148. https://doi.org/10.1080/10408399309527616

    Article  CAS  PubMed  Google Scholar 

  151. Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G (2017) Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14(8):491–502. https://doi.org/10.1038/nrgastro.2017.75

    Article  PubMed  Google Scholar 

  152. The Scientific Advisory Committee on Nutrition (2006) Folate and disease prevention. The Stationary Office, London. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/338892/SACN_Folate_and_Disease_Prevention_Report.pdf. Accessed 13 Dec 2019

  153. Centers for Disease Control and Prevention (1992) Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Recomm Rep 41(Rr–14):1–7

  154. Nowak-Wegrzyn A (2007) Food allergy to proteins. Nestle Nutr Workshop Ser Pediatr Program 59:17–31; discussion 31-16. https://doi.org/10.1159/000098510

    Article  PubMed  Google Scholar 

  155. Eigenmann PA, Sicherer SH, Borkowski TA, Cohen BA, Sampson HA (1998) Prevalence of IgE-mediated food allergy among children with atopic dermatitis. Pediatrics 101(3):E8. https://doi.org/10.1542/peds.101.3.e8

    Article  CAS  PubMed  Google Scholar 

  156. Bergmann MM, Caubet JC, Boguniewicz M, Eigenmann PA (2013) Evaluation of food allergy in patients with atopic dermatitis. J Allergy Clin Immunol Pract 1(1):22–28. https://doi.org/10.1016/j.jaip.2012.11.005

    Article  PubMed  Google Scholar 

  157. Hay WW Jr (1994) Placental transport of nutrients to the fetus. Horm Res 42(4–5):215–222. https://doi.org/10.1159/000184196

    Article  CAS  PubMed  Google Scholar 

  158. Edelbauer M, Loibichler C, Nentwich I, Gerstmayr M, Urbanek R, Szepfalusi Z (2004) Maternally delivered nutritive allergens in cord blood and in placental tissue of term and preterm neonates. Clin Exp Allergy 34(2):189–193. https://doi.org/10.1111/j.1365-2222.2004.01848.x

    Article  CAS  PubMed  Google Scholar 

  159. Jones CA, Vance GH, Power LL, Pender SL, Macdonald TT, Warner JO (2001) Costimulatory molecules in the develo** human gastrointestinal tract: a pathway for fetal allergen priming. J Allergy Clin Immunol 108(2):235–241. https://doi.org/10.1067/mai.2001.117178

    Article  CAS  PubMed  Google Scholar 

  160. Loibichler C, Pichler J, Gerstmayr M, Bohle B, Kisst H, Urbanek R, Szepfalusi Z (2002) Materno-fetal passage of nutritive and inhalant allergens across placentas of term and pre-term deliveries perfused in vitro. Clin Exp Allergy 32(11):1546–1551. https://doi.org/10.1046/j.1365-2222.2002.01479.x

    Article  CAS  PubMed  Google Scholar 

  161. Sorva R, Makinenkiljunen S, Juntunenbackman K (1994) β-Lactoglobulin secretion in human milk varies widely after cow's milk ingestion in mothers of infants with cow's milk allergy. J Allergy Clin Immunol 93(4):787–792. https://doi.org/10.1016/0091-6749(94)90259-3

    Article  CAS  PubMed  Google Scholar 

  162. Cant A, Marsden RA, Kilshaw PJ (1985) Egg and cows’ milk hypersensitivity in exclusively breast fed infants with eczema, and detection of egg protein in breast milk. Br Med J (Clin Res Ed) 291(6500):932–935. https://doi.org/10.1136/bmj.291.6500.932

    Article  CAS  Google Scholar 

  163. Palmer DJ, Gold MS, Makrides M (2008) Effect of maternal egg consumption on breast milk ovalbumin concentration. Clin Exp Allergy 38(7):1186–1191. https://doi.org/10.1111/j.1365-2222.2008.03014.x

    Article  CAS  PubMed  Google Scholar 

  164. Palmer DJ, Gold MS, Makrides M (2005) Effect of cooked and raw egg consumption on ovalbumin content of human milk: a randomized, double-blind, cross-over trial. Clin Exp Allergy 35(2):173–178. https://doi.org/10.1111/j.1365-2222.2005.02170.x

    Article  CAS  PubMed  Google Scholar 

  165. Vadas P, Wai Y, Burks W, Perelman B (2001) Detection of peanut allergens in breast milk of lactating women. JAMA 285(13):1746–1748. https://doi.org/10.1001/jama.285.13.1746

    Article  CAS  PubMed  Google Scholar 

  166. Lovegrove JA, Morgan JB, Hamptom SM (1996) Dietary factors influencing levels of food antibodies and antigens in breast milk. Acta Paediatr 85(7):778–784. https://doi.org/10.1111/j.1651-2227.1996.tb14151.x

    Article  CAS  PubMed  Google Scholar 

  167. Lilja G, Dannaeus A, Foucard T, Graff-Lonnevig V, Johansson SG, Oman H (1991) Effects of maternal diet during late pregnancy and lactation on the development of IgE and egg- and milk-specific IgE and IgG antibodies in infants. Clin Exp Allergy 21(2):195–202. https://doi.org/10.1111/j.1365-2222.1991.tb00830.x

    Article  CAS  PubMed  Google Scholar 

  168. Greer FR, Sicherer SH, Burks AW, Committee On N, Section On A, Immunology (2019) The effects of early nutritional interventions on the development of atopic disease in infants and children. Pediatrics 143(4). https://doi.org/10.1542/peds.2019-0281

  169. Cant AJ, Bailes JA, Marsden RA, Hewitt D (1986) Effect of maternal dietary exclusion on breast fed infants with eczema: two controlled studies. Br Med J (Clin Res Ed) 293(6541):231–233. https://doi.org/10.1136/bmj.293.6541.231

  170. Kramer MS, Kakuma R (2012) Maternal dietary antigen avoidance during pregnancy or lactation, or both, for preventing or treating atopic disease in the child. Cochrane Database Syst Rev 9:CD000133. https://doi.org/10.1002/14651858.CD000133.pub3

    Article  Google Scholar 

  171. Falth-Magnusson K, Oman H, Kjellman NI (1987) Maternal abstention from cow milk and egg in allergy risk pregnancies. Effect on antibody production in the mother and the newborn. Allergy 42(1):64–73. https://doi.org/10.1111/j.1398-9995.1987.tb02189.x

    Article  CAS  PubMed  Google Scholar 

  172. Lilja G, Dannaeus A, Foucard T, Graff-Lonnevig V, Johansson SG, Oman H (1989) Effects of maternal diet during late pregnancy and lactation on the development of atopic diseases in infants up to 18 months of age--in-vivo results. Clin Exp Allergy 19(4):473–479. https://doi.org/10.1111/j.1365-2222.1989.tb02416.x

    Article  CAS  PubMed  Google Scholar 

  173. Zeiger R, Heller S, Mellon M, Forsythe A, Oconnor R, Hamburger R, Schatz M (1989) Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy: a randomized study. J Allergy Clin Immunol 84(1):72–89. https://doi.org/10.1016/0091-6749(89)90181-4

    Article  CAS  PubMed  Google Scholar 

  174. Arshad SH, Matthews S, Gant C, Hide DW (1992) Effect of allergen avoidance on development of allergic disorders in infancy. Lancet 339(8808):1493–1497. https://doi.org/10.1016/0140-6736(92)91260-f

    Article  CAS  PubMed  Google Scholar 

  175. Lovegrove JA, Hampton SM, Morgan JB (1994) The immunological and long-term atopic outcome of infants born to women following a milk-free diet during late pregnancy and lactation: a pilot study. Br J Nutr 71(2):223–238. https://doi.org/10.1079/bjn19940129

    Article  CAS  PubMed  Google Scholar 

  176. Webster D, Dhondt JL, Hannon WH, Loeber G, Torresani T (1999) Quality assurance and standardization: summary of the satellite meeting, Turku, Finland, 11-12 June 1999. Acta Paediatr 88:7–12. https://doi.org/10.1080/08035259950170510

    Article  CAS  Google Scholar 

  177. Herrmann ME, Dannemann A, Gruters A, Radisch B, Dudenhausen JW, Bergmann R, Coumbos A, Weitzel HK, Wahn U (1996) Prospective study of the atopy preventive effect of maternal avoidance of milk and eggs during pregnancy and lactation. Eur J Pediatr 155(9):770–774. https://doi.org/10.1007/bf02002904

    Article  CAS  PubMed  Google Scholar 

  178. de Silva D, Geromi M, Halken S, Host A, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AE, Poulsen LK, Van Ree R, Vlieg-Boerstra B, Agache I, Grimshaw K, O'Mahony L, Venter C, Arshad SH, Sheikh A (2014) Primary prevention of food allergy in children and adults: systematic review. Allergy 69(5):581–589. https://doi.org/10.1111/all.12334

    Article  PubMed  Google Scholar 

  179. Devereux G, Seaton A (2005) Diet as a risk factor for atopy and asthma. J Allergy Clin Immunol 115(6):1109–1117; quiz 1118. https://doi.org/10.1016/j.jaci.2004.12.1139

    Article  PubMed  Google Scholar 

  180. Parigi SM, Eldh M, Larssen P, Gabrielsson S, Villablanca EJ (2015) Breast milk and solid food sha** intestinal immunity. Front Immunol 6:415. https://doi.org/10.3389/fimmu.2015.00415

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  181. Omata N, Tsukahara H, Ito S, Ohshima Y, Yasutomi M, Yamada A, Jiang M, Hiraoka M, Nambu M, Deguchi Y, Mayumi M (2001) Increased oxidative stress in childhood atopic dermatitis. Life Sci 69(2):223–228. https://doi.org/10.1016/s0024-3205(01)01124-9

    Article  CAS  PubMed  Google Scholar 

  182. Ji H, Li XK (2016) Oxidative stress in atopic dermatitis. Oxidative Med Cell Longev 2016:2721469. https://doi.org/10.1155/2016/2721469

    Article  CAS  Google Scholar 

  183. Sivaranjani N, Rao SV, Rajeev G (2013) Role of reactive oxygen species and antioxidants in atopic dermatitis. J Clin Diagn Res 7(12):2683–2685. https://doi.org/10.7860/jcdr/2013/6635.3732

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  184. Crider KS, Yang TP, Berry RJ, Bailey LB (2012) Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate’s role. Adv Nutr 3(1):21–38. https://doi.org/10.3945/an.111.000992

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  185. Folate and disease prevention. (2006). Scientific Advisory Committee on Nutrition

  186. (1992) Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR vol 41(RR-14):1–7

  187. Waterland RA, Jirtle RL (2004) Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20(1):63–68. https://doi.org/10.1016/j.nut.2003.09.011

    Article  CAS  PubMed  Google Scholar 

  188. Prescott SL, Clifton V (2009) Asthma and pregnancy: emerging evidence of epigenetic interactions in utero. Curr Opin Allergy Clin Immunol 9(5):417–426. https://doi.org/10.1097/ACI.0b013e328330634f

    Article  CAS  PubMed  Google Scholar 

  189. Warner JA, Miles EA, Jones AC, Quint DJ, Colwell BM, Warner JO (1994) Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema? Clin Exp Allergy 24(5):423–430. https://doi.org/10.1111/j.1365-2222.1994.tb00930.x

    Article  CAS  PubMed  Google Scholar 

  190. Herberth G, Heinrich J, Roder S, Figl A, Weiss M, Diez U, Borte M, Herbarth O, Lehmann I, group Ls (2010) Reduced IFN-gamma- and enhanced IL-4-producing CD4+ cord blood T cells are associated with a higher risk for atopic dermatitis during the first 2 yr of life. Pediatr Allergy Immunol 21(1 Pt 1):5–13. https://doi.org/10.1111/j.1399-3038.2009.00890.x

    Article  PubMed  Google Scholar 

  191. Keating E, Correia-Branco A, Araújo JR, Meireles M, Fernandes R, Guardão L, Guimarães JT, Martel F, Calhau C (2015) Excess perigestational folic acid exposure induces metabolic dysfunction in post-natal life. J Endocrinol 224(3):245–259. https://doi.org/10.1530/joe-14-0448

    Article  CAS  PubMed  Google Scholar 

  192. Crider KS, Cordero AM, Qi YP, Mulinare J, Dowling NF, Berry RJ (2013) Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis. Am J Clin Nutr 98(5):1272–1281. https://doi.org/10.3945/ajcn.113.065623

    Article  CAS  PubMed  Google Scholar 

  193. Husemoen LL, Toft U, Fenger M, Jorgensen T, Johansen N, Linneberg A (2006) The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy? Int J Epidemiol 35(4):954–961. https://doi.org/10.1093/ije/dyl094

    Article  PubMed  Google Scholar 

  194. Moll R, Davis B (2017) Iron, vitamin B 12 and folate. Medicine 45(4):198–203. https://doi.org/10.1016/j.mpmed.2017.01.007

    Article  Google Scholar 

  195. Stucker M, Pieck C, Stoerb C, Niedner R, Hartung J, Altmeyer P (2004) Topical vitamin B12--a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial. Br J Dermatol 150(5):977–983. https://doi.org/10.1111/j.1365-2133.2004.05866.x

    Article  CAS  PubMed  Google Scholar 

  196. Januchowski R (2009) Evaluation of topical vitamin B(12) for the treatment of childhood eczema. J Altern Complement Med 15(4):387–389. https://doi.org/10.1089/acm.2008.0497

    Article  PubMed  Google Scholar 

  197. Molloy AM, Daly S, Mills JL, Kirke PN, Whitehead AS, Ramsbottom D, Conley MR, Weir DG, Scott JM (1997) Thermolabile variant of 5, 10-methylenetetrahydrofolate reductaseassociated with low red-cell folates: implications for folate intake recommendations. Lancet 349(9065):1591–1593. https://doi.org/10.1016/s0140-6736(96)12049-3

    Article  CAS  PubMed  Google Scholar 

  198. Puri M, Kaur L, Walia GK, Mukhopadhhyay R, Sachdeva MP, Trivedi SS, Ghosh PK, Saraswathy KN (2013) MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in recurrent pregnancy losses: a case control study among north Indian women. J Perinat Med 41(5):549–554. https://doi.org/10.1515/jpm-2012-0252

    Article  CAS  PubMed  Google Scholar 

  199. Liew SC, Gupta ED (2015) Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases. Eur J Med Genet 58(1):1–10. https://doi.org/10.1016/j.ejmg.2014.10.004

    Article  PubMed  Google Scholar 

  200. Granell R, Heron J, Lewis S, Davey Smith G, Sterne JA, Henderson J (2008) The association between mother and child MTHFR C677T polymorphisms, dietary folate intake and childhood atopy in a population-based, longitudinal birth cohort. Clin Exp Allergy 38(2):320–328. https://doi.org/10.1111/j.1365-2222.2007.02902.x

    Article  CAS  PubMed  Google Scholar 

  201. Soma Y, Kashima M, Imaizumi A, Takahama H, Kawakami T, Mizoguchi M (2005) Moisturizing effects of topical nicotinamide on atopic dry skin. Int J Dermatol 44(3):197–202. https://doi.org/10.1111/j.1365-4632.2004.02375.x

    Article  CAS  PubMed  Google Scholar 

  202. Chen AC, Martin AJ, Dalziell RA, Halliday GM, Damian DL (2016) Oral nicotinamide reduces transepidermal water loss: a randomized controlled trial. Br J Dermatol 175(6):1363–1365. https://doi.org/10.1111/bjd.14648

    Article  CAS  PubMed  Google Scholar 

  203. Kouda K, Tanaka T, Kouda M, Takeuchi H, Takeuchi A, Nakamura H, Takigawa M (2000) Low-energy diet in atopic dermatitis patients: clinical findings and DNA damage. J Physiol Anthropol Appl Hum Sci 19(5):225–228. https://doi.org/10.2114/jpa.19.225

    Article  CAS  Google Scholar 

  204. Shin J, Kim YJ, Kwon O, Kim NI, Cho Y (2016) Associations among plasma vitamin C, epidermal ceramide and clinical severity of atopic dermatitis. Nutr Res Pract 10(4):398–403. https://doi.org/10.4162/nrp.2016.10.4.398

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  205. Vaughn AR, Foolad N, Maarouf M, Tran KA, Shi VY (2019) Micronutrients in atopic dermatitis: a systematic review. J Altern Complement Med 25(6):567–577. https://doi.org/10.1089/acm.2018.0363

    Article  PubMed  Google Scholar 

  206. Umar M, Sastry KS, Al Ali F, Al-Khulaifi M, Wang E, Chouchane AI (2018) Vitamin D and the pathophysiology of inflammatory skin diseases. Skin Pharmacol Physiol 31(2):74–86. https://doi.org/10.1159/000485132

    Article  CAS  PubMed  Google Scholar 

  207. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281. https://doi.org/10.1056/NEJMra070553

    Article  CAS  PubMed  Google Scholar 

  208. Palmer DJ (2015) Vitamin D and the development of atopic eczema. J Clin Med 4(5):1036–1050. https://doi.org/10.3390/jcm4051036

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  209. Muehleisen B, Gallo RL (2013) Vitamin D in allergic disease: shedding light on a complex problem. J Allergy Clin Immunol 131(2):324–329. https://doi.org/10.1016/j.jaci.2012.12.1562

    Article  CAS  PubMed  Google Scholar 

  210. Di Filippo P, Scaparrotta A, Rapino D, Cingolani A, Attanasi M, Petrosino MI, Chuang K, Di Pillo S, Chiarelli F (2015) Vitamin D supplementation modulates the immune system and improves atopic dermatitis in children. Int Arch Allergy Immunol 166(2):91–96. https://doi.org/10.1159/000371350

    Article  CAS  PubMed  Google Scholar 

  211. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH, Dardenne O, **e Z, Arnaud RS, Feingold K, Elias PM (2004) 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J Investig Dermatol 122(4):984–992. https://doi.org/10.1111/j.0022-202X.2004.22424.x

    Article  CAS  PubMed  Google Scholar 

  212. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zugel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311(5768):1770–1773. https://doi.org/10.1126/science.1123933

    Article  CAS  PubMed  Google Scholar 

  213. Schauber J, Dorschner RA, Coda AB, Buchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zugel U, Bikle DD, Modlin RL, Gallo RL (2007) Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 117(3):803–811. https://doi.org/10.1172/jci30142

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  214. Yamanaka K, Dimitroff CJ, Fuhlbrigge RC, Kakeda M, Kurokawa I, Mizutani H, Kupper TS (2008) Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression. J Allergy Clin Immunol 121(1):148–157 e143. https://doi.org/10.1016/j.jaci.2007.08.014

    Article  CAS  PubMed  Google Scholar 

  215. Thuesen BH, Heede NG, Tang L, Skaaby T, Thyssen JP, Friedrich N, Linneberg A (2015) No association between vitamin D and atopy, asthma, lung function or atopic dermatitis: a prospective study in adults. Allergy 70(11):1501–1504. https://doi.org/10.1111/all.12704

    Article  CAS  PubMed  Google Scholar 

  216. WHO (2012) Guideline: daily iron and folic acid supplementation in pregnant women. World Health Organization, Geneva [archived]. https://www.who.int/nutrition/publications/micronutrients/guidelines/daily_ifa_supp_pregnant_women/en/. Accessed 13 Dec 2019

  217. Heine G, Hoefer N, Franke A, Nothling U, Schumann RR, Hamann L, Worm M (2013) Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults. Br J Dermatol 168(4):855–858. https://doi.org/10.1111/bjd.12077

    Article  CAS  PubMed  Google Scholar 

  218. Wang SS, Hon KL, Kong AP, Pong HN, Wong GW, Leung TF (2014) Vitamin D deficiency is associated with diagnosis and severity of childhood atopic dermatitis. Pediatr Allergy Immunol 25(1):30–35. https://doi.org/10.1111/pai.12167

    Article  PubMed  Google Scholar 

  219. Jang YH, Sim HB, Moon SY, Lee WJ, Lee SJ, ** M, Kim SH, Kim DW (2017) House dust mite sensitization is inversely associated with plasma 25-hydroxyvitamin D3 levels in patients with severe atopic dermatitis. Ann Dermatol 29(4):400–406. https://doi.org/10.5021/ad.2017.29.4.400

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  220. Weisse K, Winkler S, Hirche F, Herberth G, Hinz D, Bauer M, Roder S, Rolle-Kampczyk U, von Bergen M, Olek S, Sack U, Richter T, Diez U, Borte M, Stangl GI, Lehmann I (2013) Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy 68(2):220–228. https://doi.org/10.1111/all.12081

    Article  CAS  PubMed  Google Scholar 

  221. Wolsk HM, Chawes BL, Litonjua AA, Hollis BW, Waage J, Stokholm J, Bonnelykke K, Bisgaard H, Weiss ST (2017) Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: a combined analysis of two randomized controlled trials. PLoS One 12(10):e0186657. https://doi.org/10.1371/journal.pone.0186657

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  222. Carpenter TO, Zhang JH, Parra E, Ellis BK, Simpson C, Lee WM, Balko J, Fu L, Wong BY, Cole DE (2013) Vitamin D binding protein is a key determinant of 25-hydroxyvitamin D levels in infants and toddlers. J Bone Miner Res 28(1):213–221. https://doi.org/10.1002/jbmr.1735

    Article  CAS  PubMed  Google Scholar 

  223. Tucker LA (2017) Alpha- and gamma-tocopherol and telomere length in 5768 US men and women: a NHANES study. Nutrients 9(6). https://doi.org/10.3390/nu9060601

  224. Jaffary F, Faghihi G, Mokhtarian A, Hosseini SM (2015) Effects of oral vitamin E on treatment of atopic dermatitis: a randomized controlled trial. J Res Med Sci 20(11):1053–1057. https://doi.org/10.4103/1735-1995.172815

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  225. Tsoureli-Nikita E, Hercogova J, Lotti T, Menchini G (2002) Evaluation of dietary intake of vitamin E in the treatment of atopic dermatitis: a study of the clinical course and evaluation of the immunoglobulin E serum levels. Int J Dermatol 41(3):146–150. https://doi.org/10.1046/j.1365-4362.2002.01423.x

    Article  CAS  PubMed  Google Scholar 

  226. Hoppu U, Salo-Vaananen P, Lampi AM, Isolauri E (2005) Serum alpha- and gamma-tocopherol levels in atopic mothers and their infants are correlated. Biol Neonate 88(1):24–26. https://doi.org/10.1159/000084068

    Article  CAS  PubMed  Google Scholar 

  227. Uwitonze AM, Razzaque MS (2018) Role of magnesium in vitamin D activation and function. J Am Osteopath Assoc 118(3):181–189. https://doi.org/10.7556/jaoa.2018.037

    Article  PubMed  Google Scholar 

  228. Proksch E, Nissen HP, Bremgartner M, Urquhart C (2005) Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin. Int J Dermatol 44(2):151–157. https://doi.org/10.1111/j.1365-4632.2005.02079.x

    Article  PubMed  Google Scholar 

  229. Mazur A, Maier JA, Rock E, Gueux E, Nowacki W, Rayssiguier Y (2007) Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys 458(1):48–56. https://doi.org/10.1016/j.abb.2006.03.031

    Article  CAS  PubMed  Google Scholar 

  230. Toyran M, Kaymak M, Vezir E, Harmanci K, Kaya A, Ginis T, Kose G, Kocabas CN (2012) Trace element levels in children with atopic dermatitis. J Investig Allergol Clin Immunol 22(5):341–344

    CAS  PubMed  Google Scholar 

  231. Daily iron and folic acid supplementation in pregnant women World Health Organization

  232. Baker RD, Greer FR, Committee on Nutrition American Academy of P (2010) Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics 126(5):1040–1050. https://doi.org/10.1542/peds.2010-2576

    Article  PubMed  Google Scholar 

  233. MacKenzie EL, Iwasaki K, Tsuji Y (2008) Intracellular iron transport and storage: from molecular mechanisms to health implications. Antioxid Redox Signal 10(6):997–1030. https://doi.org/10.1089/ars.2007.1893

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  234. Roth-Walter F, Pacios LF, Bianchini R, Jensen-Jarolim E (2017) Linking iron-deficiency with allergy: role of molecular allergens and the microbiome. Metallomics 9(12):1676–1692. https://doi.org/10.1039/c7mt00241f

    Article  CAS  PubMed  Google Scholar 

  235. Nwaru BI, Hayes H, Gambling L, Craig LC, Allan K, Prabhu N, Turner SW, McNeill G, Erkkola M, Seaton A, McArdle HJ, Devereux G (2014) An exploratory study of the associations between maternal iron status in pregnancy and childhood wheeze and atopy. Br J Nutr 112(12):2018–2027. https://doi.org/10.1017/S0007114514003122

    Article  CAS  PubMed  Google Scholar 

  236. Shaheen SO, Newson RB, Henderson AJ, Emmett PM, Sherriff A, Cooke M, Team AS (2004) Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema. Eur Respir J 24(2):292–297. https://doi.org/10.1183/09031936.04.00117803

    Article  CAS  PubMed  Google Scholar 

  237. Fortes C, Mastroeni S, Mannooranparampil TJ, Di Lallo D (2019) Pre-natal folic acid and iron supplementation and atopic dermatitis in the first 6 years of life. Arch Dermatol Res 311(5):361–367. https://doi.org/10.1007/s00403-019-01911-2

    Article  CAS  PubMed  Google Scholar 

  238. Gray NA, Dhana A, Stein DJ, Khumalo NP (2019) Zinc and atopic dermatitis: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol 33(6):1042–1050. https://doi.org/10.1111/jdv.15524

    Article  CAS  PubMed  Google Scholar 

  239. Maarouf M, Vaughn AR, Shi VY (2018) Topical micronutrients in atopic dermatitis-an evidence-based review. Dermatol Ther 31(5):e12659. https://doi.org/10.1111/dth.12659

    Article  CAS  PubMed  Google Scholar 

  240. Kadiyala U, Turali-Emre ES, Bahng JH, Kotov NA, VanEpps JS (2018) Unexpected insights into antibacterial activity of zinc oxide nanoparticles against methicillin resistant Staphylococcus aureus (MRSA). Nanoscale 10(10):4927–4939. https://doi.org/10.1039/c7nr08499d

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  241. Mesias M, Seiquer I, Navarro MP (2012) Is the Mediterranean diet adequate to satisfy zinc requirements during adolescence? Public Health Nutr 15(8):1429–1436. https://doi.org/10.1017/S1368980011003429

    Article  PubMed  Google Scholar 

  242. Castro-Quezada I, Roman-Vinas B, Serra-Majem L (2014) The Mediterranean diet and nutritional adequacy: a review. Nutrients 6(1):231–248. https://doi.org/10.3390/nu6010231

    Article  PubMed  PubMed Central  Google Scholar 

  243. el-Kholy MS, Gas Allah MA, el-Shimi S, el-Baz F, el-Tayeb H, Abdel-Hamid MS (1990) Zinc and copper status in children with bronchial asthma and atopic dermatitis. J Egypt Public Health Assoc 65(5–6):657–668

    CAS  PubMed  Google Scholar 

  244. Di Toro R, Galdo Capotorti G, Gialanella G, Miraglia del Giudice M, Moro R, Perrone L (1987) Zinc and copper status of allergic children. Acta Paediatr Scand 76(4):612–617. https://doi.org/10.1111/j.1651-2227.1987.tb10530.x

    Article  PubMed  Google Scholar 

  245. Tinggi U (2008) Selenium: its role as antioxidant in human health. Environ Health Prev Med 13(2):102–108. https://doi.org/10.1007/s12199-007-0019-4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  246. Pastore S, Korkina L (2010) Redox imbalance in T cell-mediated skin diseases. Mediat Inflamm 2010:861949. https://doi.org/10.1155/2010/861949

    Article  CAS  Google Scholar 

  247. Fairris GM, Perkins PJ, Lloyd B, Hinks L, Clayton BE (1989) The effect on atopic dermatitis of supplementation with selenium and vitamin E. Acta Derm Venereol 69(4):359–362

    CAS  PubMed  Google Scholar 

  248. Ba Z (2016) Selenium in pregnant women: mini review. J Nutr Food Sci 06(03). https://doi.org/10.4172/2155-9600.1000492

  249. Pieczynska J, Grajeta H (2015) The role of selenium in human conception and pregnancy. J Trace Elem Med Biol 29:31–38. https://doi.org/10.1016/j.jtemb.2014.07.003

    Article  CAS  PubMed  Google Scholar 

  250. Scientific Opinion on Dietary Reference Values for selenium (2014). EFSA Journal 12 (10). doi:https://doi.org/10.2903/j.efsa.2014.3846

  251. Hubalewska-Dydejczyk A, Duntas L, Gilis-Januszewska A (2019) Pregnancy, thyroid, and the potential use of selenium. Hormones (Athens). https://doi.org/10.1007/s42000-019-00144-2

  252. Yamada T, Saunders T, Kuroda S, Sera K, Nakamura T, Takatsuji T, Fukuoka College of O, Gynecologists PAoFD, Hara T, Nose Y (2013) Cohort study for prevention of atopic dermatitis using hair mineral contents. J Trace Elem Med Biol 27(2):126–131. https://doi.org/10.1016/j.jtemb.2012.08.003

    Article  CAS  PubMed  Google Scholar 

  253. Pilmane M, Salma-Ancane K, Loca D, Locs J, Berzina-Cimdina L (2017) Strontium and strontium ranelate: historical review of some of their functions. Mater Sci Eng C Mater Biol Appl 78:1222–1230. https://doi.org/10.1016/j.msec.2017.05.042

    Article  CAS  PubMed  Google Scholar 

  254. Barneo-Caragol C, Martinez-Morillo E, Rodriguez-Gonzalez S, Lequerica-Fernandez P, Vega-Naredo I, Alvarez Menendez FV (2018) Strontium and oxidative stress in normal pregnancy. J Trace Elem Med Biol 45:57–63. https://doi.org/10.1016/j.jtemb.2017.09.021

    Article  CAS  PubMed  Google Scholar 

  255. Venter C, Higgins B, Grundy J, Clayton CB, Gant C, Dean T (2006) Reliability and validity of a maternal food frequency questionnaire designed to estimate consumption of common food allergens. J Hum Nutr Diet 19(2):129–138. https://doi.org/10.1111/j.1365-277X.2006.00677.x

    Article  CAS  PubMed  Google Scholar 

  256. Venter C, Brown KR, Maslin K, Palmer DJ (2017) Maternal dietary intake in pregnancy and lactation and allergic disease outcomes in offspring. Pediatr Allergy Immunol 28(2):135–143. https://doi.org/10.1111/pai.12682

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, National Taiwan University Hospital, No. 7, Chung Shan South Road, Taipei, 10002, Taiwan, Republic of China

    Chun-Min Kang & Li-Chieh Wang

  2. Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

    Chun-Min Kang

  3. Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan

    Bor-Luen Chiang

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  1. Chun-Min Kang
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Kang, CM., Chiang, BL. & Wang, LC. Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring. Clinic Rev Allerg Immunol 61, 128–155 (2021). https://doi.org/10.1007/s12016-020-08780-y

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