1,184 Result(s)

Article

Genomic mismatch scanning: a new approach to genetic linkage map**

Genomic mismatch scanning (GMS) is a new method of genetic linkage analysis that does not require conventional polymorphic markers or gel electrophoresis. GMS is ideally suited to affected–relative–pair mappin...

Stanley F. Nelson, John H. McCusker, Mark A. Sander, Yun Kee… in Nature Genetics (1993)

Article

Mosaic and polymorphic imprinting of the WT1 gene in humans

We have examined the imprinting of the Wilms' tumour suppressor gene (WT1) in human tissues. We confirm that WT1 is biallelically expressed in the kidney, however, in five of nine preterm placentae WT1 was expres...

Yoshihiro **no, Kankatsu Yun, Kunihiko Nishiwaki, Takeo Kubota… in Nature Genetics (1994)

Article

Establishment of functional imprinting of the H19 gene in human develo** placentae

We have found that the imprinted H19 gene can be expressed either biallelically or monoallelically in the develo** human placentae. H19 biallelic expression is confined to the placenta until 10 weeks of gestati...

Yoshihiro **no, Yuichiro Ikeda, Kankatsu Yun, Marion Maw… in Nature Genetics (1995)

Chapter and Conference Paper

Preventive Effects of Panax ginseng C. A. Meyer on Various Human Cancers

Since 1978 it has been thought that cancer should be conquered by prevention, and that it is not desirable to use synthetic agents for chemoprevention owing to their toxicity problems. Because Panax ginseng C. A....

Taik-Koo Yun in Food Factors for Cancer Prevention (1997)

Article

Differential adhesion of metastatic RAW117 large-cell lymphoma cells under static or hydrodynamic conditions: role of integrin alpha v beta3

RGD-containing substrates were used to study static and hydrodynamic adhesion of murine RAW117 large-cell lymphoma sublines with differential liver-metastatic potentials. Highly liver-metastatic RAW117-H10 cel...

Zhong Yun, Thomas W. Smith, David G. Menter… in Clinical & Experimental Metastasis (1997)

Article

Chromosomal deletion complexes in mice by radiation of embryonic stem cells

Chromosomal deletions (‘deficiencies’) are powerful tools in the genetic analysis of complex genomes. They have been exploited extensively in Drosophila melanogaster, an organism in which deficiencies can be effi...

Yun You, Rebecca Bergstrom, Martina Klemm, Birgit Lederman… in Nature Genetics (1997)

Article

Keratin 19 mRNA is detectable by RT-PCR in lymph nodes of patients without breast cancer

K Yun, J Gunn, AEH Merrie, LV Phillips, JL McCall in British Journal of Cancer (1997)

Article

Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potential

The ribonucleotide reductase (RR) gene has been associated with malignant transformation and metastatic potential. In this report, the significance of the expression of RR mRNA and enzymatic activity to the in...

Bing-Sen Zhou, Pamela Tsai, Rhonda Ker, Jeffrey Tsai… in Clinical & Experimental Metastasis (1998)

Article

Mutations in the gene encoding gap junction protein β-3 associated with autosomal dominant hearing impairment

Hearing impairment is the most commonly occurring condition that affects the ability of humans to communicate ¹ . More than 50%...

Jia-hui **a., Chun-yu Liu, Bei-sha Tang, Qian Pan, Lei Huang… in Nature Genetics (1998)

Article

Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1

Angiogenesis inhibitors produced by a primary tumor can create a systemic anti-angiogenic environment and maintain metastatic tumor cells in a state of dormancy^1,2. We show here that the gallbladder microenvironm...

Takeshi Gohongi, Dai Fukumura, Yves Boucher, Chae-Ok Yun, Gerald A. Soff… in Nature Medicine (1999)

Article

Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

Transplantation approaches using cellular bridges^1,2, fetal central nervous system cells^3,4,5, fibroblasts expressing neurotrophin-3 (ref. 6), hybridoma cells expressing inhibitory protein-blocking antibodies⁷, o...

John W. McDonald, **ao-Zhong Liu, Yun Qu, Su Liu, Shannon K. Mickey… in Nature Medicine (1999)

Chapter

Transplantation and Tissue Recombination Techniques to Study Mammary Gland Biology

Because certain mutant transgenic mice die prematurely or are infertile, the study of the mammary gland is hampered. To circumvent this problem, mammary transplantation techniques can be used to “rescue” mamma...

Gerald R. Cunha, Yun Kit Hom, Peter Young… in Methods in Mammary Gland Biology and Breas… (2000)

Article

The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence

Objective: We have reviewed the potential cancer-preventive and other relevant properties of Panax ginseng C. A. Meyer, which has been traditionally used as a natural tonic in Oriental countries.

Hai Rim Shin, Joon Youn Kim, Taik Koo Yun, Gareth Morgan… in Cancer Causes & Control (2000)

Article

Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa

Mutation of a receptor tyrosine kinase gene, Mertk, in the Royal College of Surgeons (RCS) rat¹ results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retina...

Andreas Gal, Yun Li, Debra A. Thompson, Jessica Weir, Ulrike Orth… in Nature Genetics (2000)

Article

A biochemical function for attractin in agouti-induced pigmentation and obesity

Agouti protein, a paracrine signaling molecule normally limited to skin, is ectopically expressed in lethal yellow (A^y) mice, and causes obesity by mimicking agouti-related protein (Agrp), found primarily in the ...

Lin He, Teresa M. Gunn, Donna M. Bouley, **n-Yun Lu, Stanley J. Watson… in Nature Genetics (2001)

Article

Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy

The chromophore of the visual pigments, 11-cis retinal, is derived from vitamin A (all-trans retinol) through a series of reactions that take place in retinal pigment epithelium (RPE); (ref. 1). The first of thes...

Debra A. Thompson, Yun Li, Christina L. McHenry, Thomas J. Carlson… in Nature Genetics (2001)

Article

Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4

Nasopharyngeal carcinoma (NPC) occurs with high frequency in Asian populations, especially among people of Cantonese ancestry. In areas with high incidence, NPC clusters in families, which suggests that both g...

Bing-Jian Feng, Wei Huang, Yin Yao Shugart, Ming K. Lee, Feng Zhang… in Nature Genetics (2002)