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  1. Article

    Open Access

    Pancreatic cancers depend on a non-canonical glutamine metabolism pathway

    Costas Lyssiotis, Jaekyoung Son, Joesph Mancias, Haoqiang Ying… in Cancer & Metabolism (2014)

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    Article

    Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

    Phosphorylation of Akt at its carboxy-terminal tail is an essential layer of Akt activation to regulate its physiological functions.

    Pengda Liu, Michael Begley, Wojciech Michowski, Hiroyuki Inuzuka, Miriam Ginzberg… in Nature (2014)

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    Chapter and Conference Paper

    Role of Phosphatidylinositol 3-Kinase in Growth Factor and Oncogene Signaling

    Phosphatidylinositol 3-kinase (PtdIns 3-Kinase) is an enzyme that phosphorylates the D-3 position of the inositol ring of the membrane lipid, phosphatidylinositol (PtdIns). It was discovered because of its hig...

    Lewis Cantley in Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling (1993)

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    Article

    The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

    COLONY stimulating f actor-1 (CSF-1) is a lineage-specific growth factor required for proliferation and survival of mononuclear phagocytes and their precursors. The CSF-1 receptor belongs to a family of ligan...

    Lyuba Varticovski, Brian Druker, Deborah Morrison, Lewis Cantley, Thomas Roberts in Nature (1989)

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    Article

    Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

    The generation of second messengers from the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdInsP2) by phospho-inositidase C has been implicated in the mediation of cellular responses to a variety of grow...

    Malcolm Whitman, C. Peter Downes, Marilyn Keeler, Tracy Keller, Lewis Cantley in Nature (1988)

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    Chapter

    Comparison of the Na+ Pump and the Ouabain-Resistant K+ Transport System with Other Metal Ion Transport ATPases

    Digitalis has long been of medical importance and was mentioned in herbal treatment as early as 1250 (Schery, 1972). This drug entered into accepted medical practice in 1785 following the experimental observat...

    Leigh English, Benjamin White, Lewis Cantley in New Insights into Cell and Membrane Transp… (1986)

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    Article

    Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

    Polyoma middle-T antigen is required for viral transformation of cultured cells and for tumorigenesis in animals. Like many other transforming gene products, middle-T is bound to the membrane and has an associ...

    Malcolm Whitman, David R. Kaplan, Brian Schaffhausen, Lewis Cantley… in Nature (1985)

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    Chapter

    Na+ and Ca2+ Fluxes and Differentiation of Transformed Cells

    Alterations in cation fluxes across the plasma membrane appear to play a central role in the regulation of cellular growth and differentiation [1,2,4,6–8,17,19]. Oocyte maturation is stimulated by Ca2+ release in...

    Lewis Cantley, Philip M. Rosoff, Robert Levenson… in Calcium in Biological Systems (1985)

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    Article

    The plasma membrane (Mg2+)-dependent adenosine triphosphatase from the human erythrocyte is not an ion pump

    The plasma membrane (Mg2+)-dependent adenosine triphosphatase ((Mg2+)-ATPase) from human erythrocytes has been tested for its ability to transport ions. Using a preparation of inside-out vesicles loaded with the ...

    Michael Forgac, Lewis Cantley in The Journal of Membrane Biology (1984)