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Article
Open AccessPractical Guide to Glucocorticoid Induced Hyperglycaemia and Diabetes
Glucocorticoids, also known as steroids, are a class of anti-inflammatory drugs utilised widely in clinical practice for a variety of conditions. They are associated with a range of side effects including abno...
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Article
Use of Patient Preference Studies in HTA Decision Making: A NICE Perspective
Patient preference studies could provide valuable insights to a National Institute for Health and Care Excellence committee into the preferences patients have for different treatment options, especially if the...
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Article
Open AccessManaging multimorbidity in primary care in patients with chronic respiratory conditions
The term multimorbidity is usually defined as the coexistence of two or more chronic conditions within an individual, whereas the term comorbidity traditionally describes patients with an index condition and o...
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Article
Open AccessDetails of development of the resource for adults with asthma in the RAISIN (randomized trial of an asthma internet self-management intervention) study
Around 300 million people worldwide have asthma and prevalence is increasing. Self-management can be effective in improving a range of outcomes and is cost effective, but is underutilised as a treatment strate...
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Article
Open AccessA Randomized trial of an Asthma Internet Self-management Intervention (RAISIN): study protocol for a randomized controlled trial
The financial costs associated with asthma care continue to increase while care remains suboptimal. Promoting optimal self-management, including the use of asthma action plans, along with regular health profes...
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Article
Open AccessErratum to: Qualitative systematic reviews of treatment burden in stroke, heart failure and diabetes - Methodological challenges and solutions
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Article
Spatial relationships between lead sources and children’s blood lead levels in the urban center of Indianapolis (USA)
Urban children remain disproportionately at risk of having higher blood lead levels than their suburban counterparts. The Westside Cooperative Organization (WESCO), located in Marion County, Indianapolis, Indi...
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Article
Open AccessQualitative systematic reviews of treatment burden in stroke, heart failure and diabetes - Methodological challenges and solutions
Treatment burden can be defined as the self-care practices that patients with chronic illness must perform to respond to the requirements of their healthcare providers, as well as the impact that these practic...
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Article
HDM2 phosphorylation by MAPKAP kinase 2
p53 stability is regulated by HDM2, a RING domain protein that acts as an E3 ligase to ubiquitinate p53 and target its degradation. Phosphorylation of HDM2 on serine 166 by AKT has been shown to enhance HDM2 a...
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Article
Raf functions downstream of Rasl in the Sevenless signal transduction pathway
SPECIFICATION of the R7 cell fate in the develo** Drosophila eye requires activation of the Sevenless (Sev) receptor tyrosine kinase, located on the surface of the R7 precursor cell, by its interaction with the...
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Article
The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase
COLONY stimulating f actor-1 (CSF-1) is a lineage-specific growth factor required for proliferation and survival of mononuclear phagocytes and their precursors. The CSF-1 receptor belongs to a family of ligan...
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Article
Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate
cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abun...
