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Article
Open AccessLoss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice
The brain cortex is responsible for many higher-level cognitive functions. Disruptions during cortical development have long-lasting consequences on brain function and are associated with the etiology of brain...
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Article
Open AccessProtein translation rate determines neocortical neuron fate
The mammalian neocortex comprises an enormous diversity regarding cell types, morphology, and connectivity. In this work, we discover a post-transcriptional mechanism of gene expression regulation, protein tra...
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Article
Open AccessGlioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
Despite a deeper molecular understanding, human glioblastoma remains one of the most treatment refractory and fatal cancers. It is known that the presence of macrophages and microglia impact glioblastoma tumor...
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Article
Open AccessMethylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells
Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the develo** mammalian brain. However, little is known ab...
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Article
Translating neural stem cells to neurons in the mammalian brain
The mammalian neocortex underlies our perception of sensory information, performance of motor activities, and higher-order cognition. During mammalian embryogenesis, radial glial precursor cells sequentially g...
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Article
RNAi screen identifies essential regulators of human brain metastasis-initiating cells
Brain metastases (BM) are the most common brain tumor in adults and are a leading cause of cancer mortality. Metastatic lesions contain subclones derived from their primary lesion, yet their functional charact...
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Nervous System Aging, Degeneration, and the p53 Family
Over the past decade, evidence has emerged implicating the p53 family members p73 and p63 in two functions that likely play key roles in maintaining long-term nervous system integrity. First, p73, acting as a ...
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Article
p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain
The authors show that myelin, signaling through the receptor p75NTR and its downstream effectors, prevents aberrant sprouting of basal forebrain cholinergic axons in the adult mouse brain.
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Article
Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells
Neurogenesis requires a switch of progenitor divisions from symmetrical and self-renewing to asymmetrical. This study shows that the Rho-activating protein Lcf is required for neurogenesis in the murine cortex...
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Article
Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration
The mechanisms that regulate the pruning of mammalian axons are just now being elucidated. Here, we describe a mechanism by which, during developmental sympathetic axon competition, winning axons secrete brain...
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Article
A dermal niche for multipotent adult skin-derived precursor cells
A fundamental question in stem cell research is whether cultured multipotent adult stem cells represent endogenous multipotent precursor cells. Here we address this question, focusing on SKPs, a cultured adult...
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Article
A move to sort life from death
Nerve growth factor determines neuronal cell fate during development or after injury. A newly identified ‘death factor’, an unprocessed form of this protein, induces cell death by activating two receptors in c...
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Article
Axon growth inhibition: signals from the p75 neurotrophin receptor
Axon growth after CNS injury is restricted in part by several inhibitors found in myelin. The inhibition requires interaction of the Nogo receptor with the p75 neurotrophin receptor. A new paper now shows that...
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Article
The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism
The Rb family of proteins, which consists of Rb, p107 and p130, are critical regulators of cell proliferation. In addition to their inhibitory effects on cell cycle progression, Rb-family proteins repress tran...
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Article
Isolation of multipotent adult stem cells from the dermis of mammalian skin
We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells derive from the dermis, and clones of individual cells can proliferate and differentiate in culture to produce neur...
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Article
PI-3 kinase and IP3: partners in NT3-induced synaptic transmission
Neurotrophins are implicated in synaptic plasticity, but the signaling pathway was unknown. A new study shows that PI-3 kinase and IP3 are necessary and sufficient for NT3's actions.
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Article
The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth
The Trk/Nerve Growth Factor receptor mediates the rapid activation of a number of intracellular signaling proteins, including phosphatidylinositol 3-kinase (PI 3-kinase). Here, we describe a novel, NGF-inducib...
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Article
Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase
The TrkA receptor protein tyrosine kinase is involved in signalling PC12 cell differentiation and cessation of cell division in response to nerve growth factor (NGF). To assess the importance of adaptor protei...
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Article
Life and death decisions: a biological role for the p75 neurotrophin receptor
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Neurotrophins and neuronal versus glial differentiation in medulloblastomas and other pediatric brain tumors
Medulloblastomas are highly malignant and poorly understood childhood neoplasms. To determine if neurotrophins might influence the phenotypic properties of medulloblastoma in a paracrine or autocrine manner, ...
