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Article
Open AccessNoninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance
The metabolic shift induced in human CD4+ T lymphocytes by stimulation is characterized by an upregulation of glycolysis, leading to an augmentation in lactate production. This adaptation has already been highlig...
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Article
Open AccessIdentifying biological mechanisms for favorable cancer prognosis using non-hypothesis-driven iterative survival analysis
Survival analyses based on the Kaplan–Meier estimate have been pervasively used to support or validate the relevance of biological mechanisms in cancer research. Recently, with the appearance of gene expressio...
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Article
Open AccessSocial networks help to infer causality in the tumor microenvironment
Networks have become a popular way to conceptualize a system of interacting elements, such as electronic circuits, social communication, metabolism or gene regulation. Network inference, analysis, and modeling...
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Article
New Insight on Bio-sensing by Nano-fabricated Memristors
We report here on a new insight for bio-sensing based on the memristive effect of functionalized Schottky-barrier memristive silicon nanowire in dry environment. The device concept is discussed. Electrical mea...
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Article
Cis association of Ly49A with MHC class I restricts natural killer cell inhibition
Natural killer (NK) cell function is negatively regulated by inhibitory receptors interacting with major histocompatibility complex class I molecules expressed on target cells. Here we show that the inhibitory...
