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Article
Open AccessTransplantation of Neural Progenitor Cells Derived from Stem Cells from Apical Papilla Through Small-Molecule Induction in a Rat Model of Sciatic Nerve Injury
Stem cell-based transplantation therapy holds promise for peripheral nerve injury treatment, but adult availability is limited. A cell culture protocol utilizing a small-molecule cocktail effectively reprogram...
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Article
Safety profile of subacute oral administration of ethanolic extract of Gracilaria manilaensis Yamamoto & Trono
Gracilaria manilaensis is a red seaweed found in some regions of Peninsula Malaysia. In vitro studies have demonstrated that G. manilaensis has neuritogenic, neuroprotective, anticancer, antioxidant, and antimicr...
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Article
Open AccessMolecular signature of excessive female aggression: study of stressed mice with genetic inactivation of neuronal serotonin synthesis
Aggression is a complex social behavior, critically involving brain serotonin (5-HT) function. The neurobiology of female aggression remains elusive, while the incidence of its manifestations has been increasi...
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Article
Open AccessFunctional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation
As a key oscillatory activity in the brain, thalamic spindle activities are long believed to support memory consolidation. However, their propagation characteristics and causal actions at systems level remain ...
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Article
Open AccessChronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives
The chronic mild stress (CMS) paradigm was first described almost 40 years ago and has become a widely used model in the search for antidepressant drugs for major depression disorder (MDD). It has resulted in ...
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Article
Open AccessNeurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression
Depression is a severe neuropsychiatric disorder that affects more than 264 million people worldwide. The efficacy of conventional antidepressants are barely adequate and many have side effects. Hericium erinaceu...
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Article
Open AccessMesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms
The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying mechanism remains unclear. We conducted a randomized, ...
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Article
Development of a tool to accurately predict UK REF funding allocation
Understanding the determinants of research funding allocation by funding bodies, such as the Research Excellence Framework (REF) in the UK, is vital to help institutions prepare for their research quality asse...
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Article
Open AccessTherapeutic roles of natural remedies in combating hereditary ataxia: A systematic review
Hereditary ataxia (HA) represents a group of genetically heterogeneous neurodegenerative diseases caused by dysfunction of the cerebellum or disruption of the connection between the cerebellum and other areas ...
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Article
Open AccessNeuroprotective effects of Hericium erinaceus (Bull.: Fr.) Pers. against high-dose corticosterone-induced oxidative stress in PC-12 cells
Hericium erinaceus is a culinary and medicinal mushroom in Traditional Chinese Medicines. It has numerous pharmacological effects including immunomodulatory, anti-tumour, anti-microbial, anti-aging and stimulatio...
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Article
Prelimbic Cortical Stimulation Improves Spatial Memory Through Distinct Patterns of Hippocampal Gene Expression in Aged Rats
Dementia poses major health challenges worldwide, yet current treatments are faced with issues of efficacy and toxicity. Deep brain stimulation (DBS) is a promising non-pharmacological treatment for dementia, ...
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Article
Open AccessA practical approach to the ethical use of memory modulating technologies
Recent advancements in neuroscientific techniques have allowed us to make huge progress in our understanding of memories, and in turn has paved the way for new memory modification technologies (MMTs) that can ...
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Article
Open AccessHericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia
Cerebellar ataxia is a neurodegenerative disorder with no definitive treatment. Although several studies have demonstrated the neuroprotective effects of Hericium erinaceus (H.E.), its mechanisms in cerebellar at...
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Article
Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation
Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful as an unconditioned stimulus for modelling anticipatory fear and...
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Article
Electrical Stimulation Normalizes c-Fos Expression in the Deep Cerebellar Nuclei of Depressive-like Rats: Implication of Antidepressant Activity
The electrical stimulation of specific brain targets has been shown to induce striking antidepressant effects. Despite that recent data have indicated that cerebellum is involved in emotional regulation, the m...
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Article
Open AccessTetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice
Tetratricopeptide repeat domain 9A (TTC9A) expression is abundantly expressed in the brain. Previous studies in TTC9A knockout (TTC9A−/−) mice have indicated that TTC9A negatively regulates the action of estrogen...
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Article
Open AccessPluripotent Human embryonic stem cell derived neural lineages for in vitro modelling of enterovirus 71 infection and therapy
The incidence of neurological complications and fatalities associated with Hand, Foot & Mouth disease has increased over recent years, due to emergence of newly-evolved strains of Enterovirus 71 (EV71). In the...
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Chapter
Neurosurgical Treatments of Depression
The neurosurgical treatment of treatment-resistant depression (TRD) has entered a new era with more and more patients being treated with deep brain stimulation (DBS) via surgically implanted intracerebral elec...
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Article
Open AccessPeriaqueductal Grey Stimulation Induced Panic-Like Behaviour Is Accompanied by Deactivation of the Deep Cerebellar Nuclei
Until recently, the cerebellum was primarily considered to be a structure involved in motor behaviour. New anatomical and clinical evidence has shown that the cerebellum is also involved in higher cognitive fu...
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Chapter and Conference Paper
Basal Ganglia and Behaviour: Behavioural Effects of Deep Brain Stimulation in Experimental Neurological and Psychiatric Disorders
The use of deep brain stimulation (DBS) to control severely disabling neurological and psychiatric conditions is an exciting and fast emerging area of neuroscience. Deep brain stimulation has generally the sam...
