12 Result(s)

Article

Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons

Well-balanced mitochondrial fission and fusion processes are essential for nervous system development. Loss of function of the main mitochondrial fission mediator, dynamin-related protein 1 (Drp1), is lethal e...

B Oettinghaus, J M Schulz, L M Restelli, M Licci, C Savoia… in Cell Death & Differentiation (2016)

Article

Early effects of the antineoplastic agent salinomycin on mitochondrial function

Salinomycin, isolated from Streptomyces albus, displays antimicrobial activity. Recently, a large-scale screening approach identified salinomycin and nigericin as selective apoptosis inducers of cancer stem cells...

A Managò, L Leanza, L Carraretto, N Sassi, S Grancara… in Cell Death & Disease (2015)

Article

The endogenous caspase-8 inhibitor c-FLIP_L regulates ER morphology and crosstalk with mitochondria

Components of the death receptor-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets. In this study, we report th...

E S Marini, C Giampietri, S Petrungaro, S Conti… in Cell Death & Differentiation (2015)

Article

When numbers matters: mitochondrial DNA and gliomagenesis

E Barbieri, L Scorrano in Cell Death & Differentiation (2013)

Article

Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency

Mitochondrial complex I dysfunction has long been associated with Parkinson’s disease (PD). Recent evidence suggests that mitochondrial involvement in PD may extend beyond a sole respiratory deficit and also i...

D Ramonet, C Perier, A Recasens, B Dehay, J Bové, V Costa… in Cell Death & Differentiation (2013)

Article

Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation

During myogenic differentiation the short mitochondria of myoblasts change into the extensively elongated network observed in myotubes. The functional relevance and the molecular mechanisms driving the formati...

C De Palma, S Falcone, S Pisoni, S Cipolat, C Panzeri… in Cell Death & Differentiation (2010)

Article

Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin

During apoptosis, mitochondria lose their membrane potential and undergo fragmentation around the time of release of cytochrome c. Apoptotic fission is at least in part sustained by the translocation of dynamin-r...

G M Cereghetti, V Costa, L Scorrano in Cell Death & Differentiation (2010)

Article

Endosome–mitochondria juxtaposition during apoptosis induced by H. pylori VacA

The vacuolating cytotoxin (VacA) is an important virulence factor of Helicobacter pylori with pleiotropic effects on mammalian cells, including the ability to trigger mitochondria-dependent apoptosis. However, th...

F Calore, C Genisset, A Casellato, M Rossato, G Codolo… in Cell Death & Differentiation (2010)

Article

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its mechanisms constitutes a fo...

L Galluzzi, S A Aaronson, J Abrams, E S Alnemri… in Cell Death & Differentiation (2009)

Article

A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis

Mitochondria are crucial amplifiers of death signals. They release cytochrome c and other pro-apoptotic factors required to fully activate effector caspases. This release is accompanied by fragmentation of the mi...

L Pellegrini, L Scorrano in Cell Death & Differentiation (2007)

Article

To fuse and to protect. A novel role for CED-9 in mitochondrial morphology reveals an ancient function

S Cipolat, L Scorrano in Cell Death & Differentiation (2006)

Article

Laying the foundations of programmed cell death

A Letai, L Scorrano in Cell Death & Differentiation (2006)