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Article
Open AccessDYRK1A promotes dopaminergic neuron survival in the develo** brain and in a mouse model of Parkinson’s disease
In the brain, programmed cell death (PCD) serves to adjust the numbers of the different types of neurons during development, and its pathological reactivation in the adult leads to neurodegeneration. Dual-spec...
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Article
Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency
Mitochondrial complex I dysfunction has long been associated with Parkinson’s disease (PD). Recent evidence suggests that mitochondrial involvement in PD may extend beyond a sole respiratory deficit and also i...
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Article
Notes on the hydroxamate assay for amino acid activating enzymes
Die durch die Hydroxamatmethode bestimmte Aktivität von Aminosäureaktivierungsenzymen wird durch das Alter der angewandten NH2OH·HCl-Lösung, durch manchmal vorhandene Hydroxamat spaltende Enzyme sowie durch Unzul...