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Article
Open AccessEmotion dysregulation, impulsivity and anger rumination in borderline personality disorder: the role of amygdala and insula
Borderline Personality Disorder (BPD) is a severe mental disorder, characterized by deficits in emotion regulation, interpersonal dysfunctions, dissociation and impulsivity. Brain abnormalities have been gener...
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Article
Post-operative morbidity in Crohn’s disease: what is the impact of patient-, disease- and surgery-related factors?
Over 50% of patients suffering from Crohn’s disease (CD) require surgery in their lifetime. Predictors/risk factors of post-operative morbidity and mortality in CD are poorly investigated. We aimed to assess t...
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Article
Open AccessComparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling
Autosomal-dominant polycystic kidney disease (ADPKD) is an orphan disease with few current treatment options. The vasopressin V2 receptor antagonist tolvaptan is approved in multiple countries for the treatment o...
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Article
The coming of age of the mitochondria–ER contact: a matter of thickness
The sites of near-contact between the mitochondrion and the endoplasmic reticulum (ER) have earned a lot of attention due to their key role in the maintenance of lipid and calcium (Ca2+) homeostasis, in the initi...
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Article
Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma
Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos. However, to date,...
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Article
Open AccessAspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression
High-mobility group box 1 (HMGB1) is an inflammatory molecule that has a critical role in the initiation and progression of malignant mesothelioma (MM). Aspirin (acetylsalicylic acid, ASA) is the most widely u...
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Article
Comparison of peripherally inserted central venous catheters (PICC) versus subcutaneously implanted port-chamber catheters by complication and cost for patients receiving chemotherapy for non-haematological malignancies
Indwelling central venous catheters (CVCs) have been increasingly used to enable delivery of intravenous chemotherapy. We aimed to compare the safety and cost of two commonly used CVCs, peripherally inserted c...
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Article
SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH
Mitochondrial sirtuin 3 (SIRT3) mediates cellular resistance toward various forms of stress. Here, we show that in mammalian cells subjected to hypoxia and staurosporine treatment SIRT3 prevents loss of mitoch...
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Article
Structural and mechanistic basis of Parl activity and regulation
The mitochondrial rhomboid protease Parl governs apoptosis, morphology, metabolism and might be implicated in Parkinson's disease, but the structural basis of its activity and complex regulation remain unknown...
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Chapter
Ischémie cér ébrale: Physiopathologie, diagnostic et traitement
Dans les pays industrialisés, les accidents vasculaires cérébraux (AVC) représentent la 3e cause de mortalité après les cardiopathies et les cancers, et la 1re cause de handicap acquis de l’adulte (1). Il est dés...
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Article
Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis
Hax1 has an important role in immunodeficiency syndromes and apoptosis. A recent report (Chao et al., Nature, 2008) proposed that the Bcl-2-family-related protein, Hax1, suppresses apoptosis in lymphocytes and ne...
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Article
On Regularity for Constrained Extremum Problems. Part 2: Necessary Optimality Conditions
A particular theorem for linear separation between two sets is applied in the image space associated with a constrained extremum problem. In this space, the two sets are a convex cone, depending on the constra...
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Article
On Regularity for Constrained Extremum Problems. Part 1: Sufficient Optimality Conditions
The main aspect of the paper consists in the application of a particular theorem of separation between two sets to the image associated with a constrained extremum problem. In the image space, the two sets are...
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Article
Salt water intrusion in the coastal aquifer of the southern Po Plain, Italy
Saltwater has invaded the coastal aquifer along the southern Adriatic coast of the Po Plain in Italy. The topography, morphology and land use of the region is complex: rivers, canals, wetlands, lagoons, urban,...
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Article
Extensions of homogeneous polynomials on c 0(l 2 i )
We show that a 2-homogeneous polynomial on the complex Banach space c 0 l 2 i ...
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Article
A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis
Mitochondria are crucial amplifiers of death signals. They release cytochrome c and other pro-apoptotic factors required to fully activate effector caspases. This release is accompanied by fragmentation of the mi...
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Article
Book Review
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Chapter
Activation Mechanism of Fibroblast Growth Factor Receptor Tyrosine Kinase Revealed by Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Fibroblast Growth Factor and Heparin
Fibroblast growth factors (FGF) are a family of polypeptides with a pleiotropic range of physiological and pathological activities. Association of fibroblast growth factor with its receptor tyrosine kinase (FG...
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Article
Prognostisch relevante Faktoren in der Behandlung des posttraumatisch instabilen Schultergelenks
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Article
Coercivity and image of constrained extremum problems
The concept of coercivity is extended to the image space, and it is exploited to obtain a lower bound for the minimum of a constrained extremum problem and a sufficient condition for the optimality. Problems w...
