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    Article

    In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson’s disease

    Animal models are essential tools for basic pathophysiological research as well as validation of therapeutic strategies for curing human diseases. However, technical difficulties associated with classical tran...

    L Chansel-Debordeaux, M Bourdenx, S Dovero, V Grouthier, N Dutheil… in Gene Therapy (2017)

  2. Article

    Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency

    Mitochondrial complex I dysfunction has long been associated with Parkinson’s disease (PD). Recent evidence suggests that mitochondrial involvement in PD may extend beyond a sole respiratory deficit and also i...

    D Ramonet, C Perier, A Recasens, B Dehay, J Bové, V Costa… in Cell Death & Differentiation (2013)

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