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  1. Article

    Is Slow-Onset Long-Acting Monoamine Transport Blockade to Cocaine as Methadone is to Heroin? Implication for Anti-Addiction Medications

    The success of methadone in treating opiate addiction has suggested that long-acting agonist therapies may be similarly useful for treating cocaine addiction. Here, we examined this hypothesis, using the slow-...

    **ao-Qing Peng, Zheng-**ong **, **a Li, Krista Spiller, Jie Li… in Neuropsychopharmacology (2010)

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    Conformational preferences of the potent dopamine reuptake blocker BTCP and its analogs and their incorporation into a pharmacophore model

    Molecular mechanics calculations using MM3-92 and ab initio quantum mechanical calculations using SPARTAN 5.0 were performed on the structurally similar PCP and BTCP, in which only the latter has a cocaine-lik...

    Mark Froimowitz, Kuo-Ming Wu, Jason Rodrigo… in Journal of Computer-Aided Molecular Design (2000)

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    Crystal Structures of Analogs of threo-Methylphenidate

    The crystal structures of the chloride salts of five analogs of threo-methylphenidate have been obtained. Four of these have different substituents on the phenyl ring while the fifth is the ethyl ester of methylp...

    Mark Froimowitz, Kuo-Ming Wu, Clifford George, Don VanDerveer… in Structural Chemistry (1998)