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  1. Article

    Is Slow-Onset Long-Acting Monoamine Transport Blockade to Cocaine as Methadone is to Heroin? Implication for Anti-Addiction Medications

    The success of methadone in treating opiate addiction has suggested that long-acting agonist therapies may be similarly useful for treating cocaine addiction. Here, we examined this hypothesis, using the slow-...

    **ao-Qing Peng, Zheng-**ong **, **a Li, Krista Spiller, Jie Li… in Neuropsychopharmacology (2010)

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  2. Article

    Mechanism-based medication development for the treatment of nicotine dependence

    Tobacco use is a global problem with serious health consequences. Though some treatment options exist, there remains a great need for new effective pharmacotherapies to aid smokers in maintaining long-term abs...

    Zheng-xiong **, Krista Spiller, Eliot L Gardner in Acta Pharmacologica Sinica (2009)

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  3. Article

    Metabotropic Glutamate Receptor 7 Modulates the Rewarding Effects of Cocaine in Rats: Involvement of a Ventral Pallidal GABAergic Mechanism

    The metabotropic glutamate receptor 7 (mGluR7) has received much attention as a potential target for the treatment of epilepsy, major depression, and anxiety. In this study, we investigated the possible involv...

    **a Li, Jie Li, **ao-Qing Peng, Krista Spiller, Eliot L Gardner… in Neuropsychopharmacology (2009)

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  4. Article

    Cannabinoid CB1 Receptor Antagonists Attenuate Cocaine's Rewarding Effects: Experiments with Self-Administration and Brain-Stimulation Reward in Rats

    Previous studies suggest that cannabinoid CB1 receptors do not appear to be involved in cocaine's rewarding effects, as assessed by the use of SR141716A, a prototypic CB1 receptor antagonist and CB1-knockout m...

    Zheng-**ong **, Krista Spiller, Arlene C Pak, Jeremy Gilbert… in Neuropsychopharmacology (2008)

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    Article

    The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats

    We have previously reported that selective antagonism of brain D3 receptors by SB-277011A or NGB 2904 significantly attenuates cocaine- or nicotine-enhanced brain stimulation reward (BSR).

    Krista Spiller, Zheng-**ong **, **ao-Qing Peng, Amy H. Newman… in Psychopharmacology (2008)